The Dynamic Landscape of the Coagulome of Metastatic Malignant Melanoma

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(4), С. 1435 - 1435

Опубликована: Фев. 8, 2025

The local expression of coagulation-related genes defines the tumor coagulome. coagulome plays a pivotal role in cancer-associated thrombosis (CAT) and hemostatic complications, such as venous thromboembolism (VTE), which are frequent patients with advanced/metastatic cancer. Genomic analyses human tumors, skin cutaneous melanoma (SKCM), have unveiled complexity metastatic trajectories. However, no study to date has focused on along these Using bulk-tumor single-cell primary SKCM, metastastic samples circulating cells (CTCs), we explored SKCM progression. We identified consistent changes metastases compared tumors observed site specificity. Compared other sites, lung had specific higher F3, encoding Tissue Factor. Single-cell were used chart inter- intra-tumor heterogeneity characterize SKCM. found that subpopulation CTCs from expressed high levels platelet genes, suggesting contribution CTC–platelet interactions CTC These findings highlight dynamic properties its link cancer

Язык: Английский

The roles of cancer stem cells and therapeutic implications in melanoma

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 14, 2024

Melanoma is a highly malignant skin tumor characterized by high metastasis and poor prognosis. Recent studies have highlighted the pivotal role of melanoma stem cells (MSCs)-a subpopulation cancer (CSCs)-in driving growth, metastasis, therapeutic resistance, recurrence. Similar to CSCs in other cancers, MSCs possess unique characteristics, including specific surface markers, dysregulated signaling pathways, ability thrive within complex microenvironment (TME). This review explored current landscape MSC research, discussing identification MSC-specific key pathways such as Wnt/β-catenin, Notch, Hedgehog (Hh), how interactions TME, hypoxia immune cells, contribute MSC-mediated drug resistance metastatic behavior. Furthermore, we also investigated latest strategies targeting MSCs, small-molecule inhibitors, immune-based approaches, novel vaccine developments, with an emphasis on their potential overcome progression improve clinical outcomes. aims provide valuable insights into roles biology offers perspectives for future research advances against this challenging disease.

Язык: Английский