Microbiome-Driven Therapeutics: From Gut Health to Precision Medicine
Gastrointestinal Disorders,
Год журнала:
2025,
Номер
7(1), С. 7 - 7
Опубликована: Янв. 15, 2025
The
human
microbiome,
a
complex
ecosystem
of
microorganisms
residing
in
and
on
the
body,
plays
pivotal
role
regulation
wide
range
physiological
processes,
including
digestion,
immune
responses,
metabolic
functions.
In
recent
years,
rapidly
growing
field
microbiome-driven
therapeutics
has
garnered
significant
attention
owing
to
its
potential
revolutionize
healthcare.
This
review
explores
evolving
landscape
microbiome-based
therapies,
with
particular
focus
gut
microbiome
implications
for
both
health
precision
medicine.
We
highlight
advances
understanding
how
microbial
communities
influence
disease
pathogenesis
treatment
outcomes,
spanning
conditions
such
as
inflammatory
bowel
(IBD),
disorders,
neurological
diseases,
even
cancer.
article
also
discusses
emerging
therapeutic
strategies,
probiotics,
prebiotics,
fecal
microbiota
transplantation
(FMT),
microbial-based
drugs,
well
challenges
associated
their
clinical
implementation.
Additionally,
we
examined
integration
profiling
metagenomic
data
is
advancing
medicine,
paving
way
personalized
effective
treatments.
serves
comprehensive
resource
that
synthesizes
current
knowledge,
identifies
key
gaps
research,
offers
insights
into
future
direction
therapeutics,
thus
providing
valuable
framework
clinicians,
researchers,
policymakers
seeking
harness
microbiomes
advance
healthcare
solutions.
Язык: Английский
The Intersection of the Upper Gastrointestinal Microbiome and Oesophageal Cancer: A Review of Pathways and Therapeutic Insights
European Medical Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
The
upper
gastrointestinal
microbiome,
a
complex
ecosystem
of
microorganisms
that
have
historically
been
difficult
to
identify,
may
play
pivotal
role
in
the
development
oesophageal
cancer
and
postoperative
outcomes.
Dysbiosis,
characterised
by
imbalances
microbial
composition,
is
believed
drive
tumorigenesis
various
cancers
through
mechanisms
such
as
chronic
inflammation,
immune
suppression,
epithelial
barrier
dysfunction.
Additionally,
dysbiosis
contribute
complications,
including
anastomotic
leaks
infections
following
surgery.
Most
research
date
has
focused
on
colorectal
cancer,
demonstrating
these
relationships.
Pathogenic
bacteria
exacerbate
dysregulation
processes
pro-inflammatory
cytokine
release,
evasion,
biofilm
formation.
Therapeutic
strategies
targeting
microbiome
hold
promise
for
restoring
balance,
reducing
systemic
improving
surgical
This
review
synthesises
current
evidence
microbiome’s
pathogenesis
outcomes,
highlighting
opportunities
therapeutic
interventions
potential
integrating
into
management
protocols.
Язык: Английский
Beyond Genetics: Exploring Lifestyle, Microbiome, and Social Determinants in Oral Cancer Development
Cancers,
Год журнала:
2025,
Номер
17(7), С. 1094 - 1094
Опубликована: Март 25, 2025
Oral
cancer
refers
to
cancers
originating
in
the
oral
cavity
and
oropharyngeal
regions.
It
is
16th
most
prevalent
sixth
leading
cause
of
cancer-related
deaths.
However,
mechanisms
its
progression
are
still
being
understood,
interventions
provide
early
diagnosis
need
be
improved.
More
studies
have
recently
been
conducted
on
cancer,
many
reviews
summarized
findings
this
field,
focusing
individual
factors.
few
review
articles
evaluated
combinational
impacts
different
factors
cancer.
This
aimed
an
overview
effects
three
extracellular
factors,
including
lifestyle
habits,
microbiome,
socioeconomic
progression.
differentially
affected
by
habits;
high-sugar
diets,
processed
foods,
alcohol,
smoking,
possibly
sleep
disorders
benefit
progression,
whereas
eating
natural
such
as
fruits,
vegetables,
fish,
garlic,
drinking
tea
or
coffee,
physical
exercise
can
combat
it.
The
microbiome
could
suppress
promote
Low
status
impact
development.
Furthermore,
crosstalk
among
these
affects
has
limitations
not
all
cancer-affecting
important
publications.
focus
should
placed
multiple
treatment.
study
update
researchers
landscape
help
formulate
approaches
prevention
Язык: Английский
An Overview of the Etiopathogenic Mechanisms Involved in the Expression of the Oral Microbiota
Clinics and Practice,
Год журнала:
2025,
Номер
15(4), С. 80 - 80
Опубликована: Апрель 11, 2025
Background/Objectives:
The
diversity
of
the
oral
microbiota
exerts
its
effects
in
maintaining
dental
and
overall
health.
unique
genetic
profile
each
individual
influences
composition
microbiota,
determining
susceptibility
to
certain
diseases.
aim
is
observe
role
by
highlighting
pathogenic
mechanisms
involved
dysbiosis
identify
determinism's
influence
balance.
Methods:
This
study
was
designed
as
a
narrative
review
utilizing
some
principles
guidelines
systematic
increase
methodological
rigor.
We
examined
121
articles
such
reviews,
meta-analyses,
editorials,
observational
studies,
which
met
inclusion
exclusion
criteria.
criteria
for
studies
were
follows:
(1)
that
evaluated
impact
or/and
systemic
diseases;
(2)
observed
microbiota;
(3)
interaction
with
immune
system
(4);
implications
microbiota.
Results:
Host
genes
regulate
inflammatory
immunological
reactions
play
microbiological
explains
increased
resistance
diseases,
including
gingivitis
or
periodontitis.
Also,
are
reflected
not
only
locally,
but
also
generally,
being
associated
various
conditions.
Conclusions:
Understanding
determinants
may
help
create
individualized
therapies
preventing
managing
disorders.
A
healthy
lifestyle
adequate
hygiene
can
facilitate
diverse
balanced
microbiome,
crucial
Язык: Английский
Comparative analysis of bacterial abundance and diversity in tumour tissue of oral squamous cell carcinoma and non-tumour tissue: insights from a systematic review of 16S ribosomal RNA sequencing
BMC Oral Health,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 16, 2025
Язык: Английский
Oral Microbiome Research in Biopsy Samples of Oral Potentially Malignant Disorders and Oral Squamous Cell Carcinoma and Its Challenges
Applied Sciences,
Год журнала:
2024,
Номер
14(23), С. 11405 - 11405
Опубликована: Дек. 7, 2024
This
study
aims
to
evaluate
the
potential
benefits
and
challenges
of
integrating
oral
microbiome
research
into
clinical
management
potentially
malignant
disorders
(OPMD)
squamous
cell
carcinoma
(OSCC).
The
has
gained
significant
attention
for
its
role
in
pathogenesis
progression
these
conditions,
with
emerging
evidence
suggesting
value
as
a
diagnostic
prognostic
tool.
By
critically
analyzing
current
methodological
considerations,
this
manuscript
examines
whether
analysis
biopsy
samples
can
aid
early
detection,
prognosis,
OPMD
OSCC.
complexity
dynamic
nature
require
multifaceted
approach
fully
understand
utility.
Based
on
review,
we
conclude
that
studying
context
holds
promise
but
also
faces
notable
challenges,
including
variability
need
standardization.
Ultimately,
addresses
question,
“Should
such
be
undertaken,
given
intricate
interactions
various
factors
inherent
obstacles
involved?”,
emphasizes
importance
further
optimize
applications
improve
patient
outcomes.
Язык: Английский