Risk factors, prevention, diagnosis, and immunotherapy’s involvement in the fight against oral cancer: a comprehensive review
Exploration of Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Oral
cancer
is
rare
in
Western
nations
but
widespread
high-risk
regions
around
the
globe.
Risk
factors,
such
as
tobacco
usage,
alcohol
intake,
and
betel
nut
chewing,
enhance
chance
of
illness,
making
it
mostly
avoidable.
Due
to
its
high
mortality,
early
detection
crucial.
Prevention
diagnosis
begin
with
oral
mucosa
lesions
that
may
be
malignant
local
diseases
cause
persistent
inflammation.
Clinical
therapies
for
include
surgery,
radiation,
chemotherapy.
Unsatisfactory
therapeutic
impact
harmful
side
effects
remain
clinical
treatment’s
key
issues.
Future
research
should
examine
microenvironment
treatment.
This
review
examined
risk
preventative
strategies,
diagnostic
approaches.
also
discusses
immunotherapy
methods
countering
this
fatal
disease.
Immunotherapy
targeting
provide
a
novel
Язык: Английский
Semaglutide, a glucagon-like peptide-1 receptor agonist, inhibits oral squamous cell carcinoma growth through P38 MAPK signaling pathway
Journal of Cancer Research and Clinical Oncology,
Год журнала:
2025,
Номер
151(3)
Опубликована: Март 7, 2025
Researches
have
shown
that
diabetes
mellitus
(DM)
can
promote
the
risk
and
progression
of
oral
squamous
cell
carcinoma
(OSCC).
Semaglutide,
a
glucagon-like
peptide-1
receptor
agonist,
is
currently
employed
to
treat
type
2
(T2DM)
obesity.
This
study
intends
explore
potential
effects
mechanism
Semaglutide
on
OSCC.
The
expression
GLP-1R
in
OSCC
cells
tissues
was
evaluated
by
qRT-PCR,
western
blot
immunohistochemistry
assays.
Cell
proliferation,
invasion,
migration
apoptosis
abilities
were
determined
relevant
experiments.
Western
verify
proteins
examine
effect
MAPK
signaling
pathway.
xenograft
transplantation
model
established
anti-cancer
vivo
assays
performed
tumor
tissues.
elevated
as
compared
with
normal.
effectively
inhibited
invasion
while
concurrently
promoting
apoptosis.
Moreover,
specifically
activated
P38
pathway
without
significant
influence
ERK1/2
or
SAPK/JNK,
its
pro-apoptotic
related
activation.
Animal
experiments
verified
inhibitory
tumors
mice.
exerts
actions
may
induce
via
has
implications
for
treatment
patients
who
are
also
afflicted
Язык: Английский
Repositioning antimalarial drugs as anticancer agents: focus on Tafenoquine
Experimental Cell Research,
Год журнала:
2025,
Номер
unknown, С. 114551 - 114551
Опубликована: Апрель 1, 2025
Язык: Английский
Metformin in Antiviral Therapy: Evidence and Perspectives
Viruses,
Год журнала:
2024,
Номер
16(12), С. 1938 - 1938
Опубликована: Дек. 18, 2024
Metformin,
a
widely
used
antidiabetic
medication,
has
emerged
as
promising
broad-spectrum
antiviral
agent
due
to
its
ability
modulate
cellular
pathways
essential
for
viral
replication.
By
activating
AMPK,
metformin
depletes
energy
reserves
that
viruses
rely
on,
effectively
limiting
the
replication
of
pathogens
such
influenza,
HIV,
SARS-CoV-2,
HBV,
and
HCV.
Its
role
in
inhibiting
mTOR
pathway,
crucial
protein
synthesis
reactivation,
is
particularly
significant
managing
infections
caused
by
CMV,
EBV.
Furthermore,
reduces
oxidative
stress
reactive
oxygen
species
(ROS),
which
are
critical
replicating
arboviruses
Zika
dengue.
The
drug
also
regulates
immune
responses,
differentiation,
inflammation,
disrupting
life
cycle
HPV
potentially
other
viruses.
These
diverse
mechanisms
suppress
replication,
enhance
system
functionality,
contribute
better
clinical
outcomes.
This
multifaceted
approach
highlights
metformin’s
potential
an
adjunctive
therapy
treating
wide
range
infections.
Язык: Английский