The Diagnostic Role of the Platelet-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis DOI Open Access
Magdalena Bizoń, Maciej Olszewski,

Boguslawa Krason

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1841 - 1841

Опубликована: Фев. 21, 2025

Ovarian cancer is among the most lethal gynecologic malignancies, often diagnosed at advanced stages due to a lack of effective screening tools. Recent studies suggest that platelet-to-lymphocyte ratio (PLR), an indicator systemic inflammation, may serve as potential biomarker for diagnosing and staging ovarian cancer. We conducted systematic review meta-analysis, adhering PRISMA guidelines. searched PubMed/Medline, Scopus, Web Science, EMBASE databases. pooled data using random-effects model assess sensitivity, specificity, diagnostic performance PLR in The meta-analysis 22 comprising 5740 participants showed significantly elevated (PLR) values patients compared healthy controls, with mean difference 46.84 (p < 0.001). Additionally, demonstrated utility distinguishing benign from malignant lesions early-stage advanced-stage While shows cost-effective accessible diagnosis staging, its accuracy remains moderate. Therefore, combining other tools enhances clinical decision-making.

Язык: Английский

The Diagnostic Role of the Platelet-to-Lymphocyte Ratio in Ovarian Cancer: A Systematic Review and Meta-Analysis DOI Open Access
Magdalena Bizoń, Maciej Olszewski,

Boguslawa Krason

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1841 - 1841

Опубликована: Фев. 21, 2025

Ovarian cancer is among the most lethal gynecologic malignancies, often diagnosed at advanced stages due to a lack of effective screening tools. Recent studies suggest that platelet-to-lymphocyte ratio (PLR), an indicator systemic inflammation, may serve as potential biomarker for diagnosing and staging ovarian cancer. We conducted systematic review meta-analysis, adhering PRISMA guidelines. searched PubMed/Medline, Scopus, Web Science, EMBASE databases. pooled data using random-effects model assess sensitivity, specificity, diagnostic performance PLR in The meta-analysis 22 comprising 5740 participants showed significantly elevated (PLR) values patients compared healthy controls, with mean difference 46.84 (p < 0.001). Additionally, demonstrated utility distinguishing benign from malignant lesions early-stage advanced-stage While shows cost-effective accessible diagnosis staging, its accuracy remains moderate. Therefore, combining other tools enhances clinical decision-making.

Язык: Английский

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