Pancreatic cancer: failures and hopes—a review of new promising treatment approaches

Exploration of Targeted Anti-tumor Therapy, Год журнала: 2025, Номер 6

Опубликована: Март 18, 2025

Pancreatic cancer is a challenging disease with limited treatment options and high mortality rate. Just few therapy advances have been made in recent years. Tumor microenvironment, immunosuppressive features mutational status represent important obstacles the improvement of survival outcomes. Up to now, first-line did achieve median overall less than 12 months this discouraging data lead clinicians all over world focus their efforts on various fields investigation: 1) sequential cycling different systemic order overcome mechanisms resistance; 2) discovery new predictive bio-markers, target specific patient population; 3) combination treatment, modulate tumor microenvironment pancreatic cancer; 4) modalities delivery drugs pass physical barrier desmoplasia stroma. This review shows future directions strategies advanced through deep analysis these macro areas research.

Язык: Английский

Tumor-Treating Fields Alter Nanomechanical Properties of Pancreatic Ductal Adenocarcinoma Cells Co-Cultured with Extracellular Matrix

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(5), С. 160 - 160

Опубликована: Май 3, 2025

Tumor-Treating Fields (TTFields), a novel therapeutic avenue, is approved for therapy in Glioblastoma multiforme, malignant pleural mesothelioma, and metastatic non-small cell lung cancer (NSCLC). In pancreatic ductal adenocarcinoma (PDAC), several clinical trials are underway to improve outcomes, yet significant knowledge gap prevails involving the cell-extracellular matrix (ECM) crosstalk. Herein, we hypothesized that treatment with TTFields influence this crosstalk, which reflected by dynamic alteration nanomechanical properties (NMPs) of cells ECM co-culture system. We employed an gel comprising collagen, fibronectin, laminin mixed 100:1:1 stoichiometry Panc1 AsPC1 individually. This mixture mimics vivo tumor microenvironment closely when compared individual components studied before. A comprehensive frequency-dependent study revealed optimal frequency be 150 kHz. also observed irrespective ECM's presence, increase membrane stiffness decrease deformation several-folds both at 48 h 72 h. Although adhesion decreased h, it was presence. Moreover, significantly alters NMPs gels co-cultured PDAC lines. However, were more detrimental these changes. Lastly, attribute changes F-actin reorganization presence TTFields. paves path complex TME as well effect various chemotherapeutic agents on such future.

Язык: Английский

Biomimetic nanosystems for pancreatic cancer therapy: A review

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113824 - 113824

Опубликована: Май 1, 2025

Язык: Английский