ACS Omega,
Год журнала:
2024,
Номер
9(50), С. 49188 - 49204
Опубликована: Дек. 9, 2024
Biodiesel
offers
an
alternative
to
fossil
fuels,
primarily
because
it
is
derived
from
renewable
sources,
with
the
potential
mitigate
issues
such
as
pollutant
and
greenhouse
gas
emissions,
resource
scarcity,
market
instability
of
petroleum
derivatives.
However,
lower
durability
stability
pose
challenges.
To
address
this,
researchers
worldwide
are
exploring
technologies
that
employ
specific
molecules
slow
down
biodiesel's
oxidation
process,
thereby
preserving
its
key
physicochemical
properties.
This
study
investigates
heterocyclic
dihydroquinolinone
derivatives
additives
enhance
oxidative
diesel-biodiesel
blends.
Comprehensive
structural
computational
analyses
were
carried
out
by
density
functional
theory
investigate
reactivity
aspects
these
compounds
additive
candidates.
The
supramolecular
arrangements
predominantly
stabilized
weak
molecular
interactions,
C-H···O
C-H···π,
which
associated
antioxidant
antibacterial
We
demonstrate
groups
can
act
electron-donating
or
electron-withdrawing
substituents.
explored
frontier
orbitals,
provide
insights
into
chemical
reactivity,
acidity,
basicity,
best
oxidizing
reducing
agents.
Finally,
maps
indicate
nucleophilic
electrophilic
regions
Fukui
indices
show
sites
nucleophilic,
electrophilic,
radical
attacks.
comprehensive
paves
way
understanding
how
dihydroquinolinone-based
serve
alternatives
for
fuel
additives.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
22(20), С. 4163 - 4171
Опубликована: Янв. 1, 2024
A
mild
and
one-pot
sequential
route
to
access
diversely
substituted
quinolinyl
dihydroquinolinones
has
been
proposed,
using
a
dehydrogenative
cyclization/alkenylation
strategy
with
good
yields.
Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Май 8, 2024
While
natural
products
have
undoubtedly
played
a
pivotal
role
in
drug
discovery,
their
potential
as
lead
compounds
has
been
hindered
by
challenges
such
limited
accessibility
and
complex
synthesis
processes.
At
the
core
of
numerous
synthetic
compounds,
each
exhibiting
remarkable
biological
traits,
lies
foundational
structure
3,4-dihydro-2(1
Natural Product Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 8
Опубликована: Май 25, 2024
Natural
products
have
played
a
crucial
role
in
drug
discovery,
but
their
development
is
hindered
by
challenges
such
as
inadequate
availability
and
complex
synthesis
methods.
However,
both
natural
synthetic
compounds
that
the
core
structure
of
3,4-dihydro-2(1
Advanced Synthesis & Catalysis,
Год журнала:
2024,
Номер
366(8), С. 1756 - 1762
Опубликована: Фев. 29, 2024
Abstract
Dihydroquinolin‐2‐ones,
recognized
for
their
bioactive
properties,
feature
a
six‐membered
structure
with
nitrogen‐containing
heterocycles.
A
method
has
been
developed
synthesizing
enantioenriched
3,4‐dihydroquinoline‐2‐one
derivatives.
This
approach
utilizes
an
asymmetric
[4+2]‐cyclization
process,
combining
2‐amino‐β‐nitrostyrenes
azlactones,
and
is
facilitated
by
bifunctional
squaramide‐based
organocatalyst.
process
enabled
the
creation
of
chiral
3,4‐dihydroquinoline‐2‐ones
complex
structures,
including
tetrasubstituted
carbon
stereocenters,
delivering
corresponding
products
in
26–95%
yield
diastereomeric
ratio
1.2:1–19:1
52–97
ee.
Organic Chemistry Frontiers,
Год журнала:
2024,
Номер
11(20), С. 5784 - 5790
Опубликована: Янв. 1, 2024
The
radical
cascade
cyclization
of
vinyl-tethered
alkenes
has
become
a
promising
tool
for
rapidly
assembling
nonbenzene-fused
cyclic
skeletons
via
the
cracking
alkenyl
C–H
bonds,
but
this
approach
been
limited
to
generate
five-membered
rings.
Abstract
An
efficient
TMSOTf‐promoted
multicomponent
reaction
has
been
developed
for
the
one‐pot
synthesis
of
quinazolin‐4
(3
H
)‐ones.
Using
TMSOTf
as
a
Lewis
acid
promoter
and
DMSO
carbon
source,
isatoic
anhydride,
primary
amines
yielded
variety
quinazolines‐4
Additionally,
promoted
2‐amino‐
N
‐substituted
benzamide
with
yielding
same
scaffolds
in
high
yields.
However,
use
DMSO‐d
6
solvent
enabled
incorporation
−CD
moiety
)‐one
skeleton.
This
proves
that
plays
twin
role
C1
source
solvent.
Various
functional
groups
containing
wide
range
)‐ones
other
heterocycles
were
employing
this
methodology.
Also,
synthetic
methodology
extended
3‐(2‐carboxyphenyl)‐4‐(3
)‐quinazolinone,
an
anti‐endotoxic
drug.
Organic & Biomolecular Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Herein,
we
present
an
efficient
Cu(
ii
)-catalyzed
cascade
synthesis
of
sulfonated
3-carboxamide
quinolin-2-(1
H
)-ones.
Inthis
paper,
sulfonylhydrazides
underwent
unusual
N–N
bond
cleavage
and
functioned
as
sulfamide
synthons.
The
sequential
synthesis
of
N-heterocycles
from
saturated
ketones
poses
significant
challenges
and
has
rarely
been
reported.
Herein,
an
efficient
alkenylated
dihydroquinolinones
7
hexahydroacridinones
8
is
achieved
1
or
2
via
dehydrogenation,
cyclization,
oxidation,
α-alkenylation
in
choline
chloride-based
deep
eutectic
solvent
(DES)
medium.
This
strategy
provides
excellent
yield
low-cost,
readily
available
starting
materials
under
environmentally
benign
conditions.
Furthermore,
the
synthesized
compounds
(4,
5,
7,
8)
were
investigated
for
their
photophysical
properties
through
absorption
emission
spectral
studies.
