Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 4, 2023
The
microbiota
gut
brain
(MGB)
axis
has
been
shown
to
play
a
significant
role
in
the
regulation
of
inflammatory
and
infective
diseases.
Exploring
structure
communication
mode
MGB
is
crucial
for
understanding
its
diseases,
studying
signaling
pathways
regulatory
methods
diseases
also
profound
significance
future
clinical
research.
This
article
reviews
composition,
mechanism
including
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
multiple
sclerosis
(MS),
autism
spectrum
disorder
(ASD),
depression,
psoriasis,
irritable
bowel
syndrome
(IBS),
(IBD).
In
addition,
our
investigation
delved
into
functions
inflammasome,
IFN-I,
NF-κB,
PARK7/DJ-1
innate
immune
pathway
context
Ultimately,
we
discussed
efficacy
various
interventions,
fecal
transplantation
(FMT),
antibiotics,
probiotics,
prebiotics,
synbiotics,
postbiotics,
management
Understanding
might
make
positive
effects
treatment
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2021,
Номер
11
Опубликована: Дек. 1, 2021
Background
Periodontal
pathogen
and
gut
microbiota
are
closely
associated
with
the
pathogenesis
of
Alzheimer’s
disease
(AD).
Porphyromonas
gingivalis
(Pg),
keystone
periodontal
pathogen,
can
induce
cognitive
impairment.
The
has
a
connection
communication
brain,
which
is
an
important
aspect
gut–brain
axis
(GBA).
In
present
study,
we
investigate
whether
Pg
induces
impairment
through
disturbing
GBA.
Methods
this
was
orally
administered
to
mice,
three
times
week
for
1
month.
effects
administration
on
brain
were
evaluated
behaviors,
microbiota,
immune
cells,
glymphatic
pathway
clearance,
neuroinflammation.
Results
induced
dysbiosis
microbiota.
α-diversity
parameters
did
not
show
significant
change
after
administration.
β-diversity
demonstrated
that
compositions
different
between
Pg-administered
control
groups.
At
species
level,
group
displayed
lower
abundance
Parabacteroides
gordonii
Ruminococcus
callidus
than
group,
but
higher
Mucispirillum
schaedleri
.
proportions
lymphocytes
in
periphery
myeloid
cells
infiltrating
increased
Pg-treated
animals.
addition,
solute
clearance
efficiency
system
decreased.
Neurons
hippocampus
cortex
regions
reduced
mice
treated
Pg.
Microglia,
astrocytes,
apoptotic
increased.
Furthermore,
amyloid
plaque
appeared
mice.
Conclusions
These
findings
indicate
may
play
role
dysbiosis,
neuroinflammation,
impairment,
turn
lead
Life Sciences,
Год журнала:
2023,
Номер
333, С. 122132 - 122132
Опубликована: Окт. 2, 2023
A
diverse
and
stable
microbiota
promotes
a
healthy
state,
nevertheless,
an
imbalance
in
gut
or
oral
bacterial
composition,
called
dysbiosis,
can
cause
gastrointestinal
disorders,
systemic
inflammatory
states
oxidative
stress,
among
others.
Recently,
dysbiosis
has
been
linked
to
Alzheimer's
disease
(AD),
which
is
considered
the
most
common
form
of
dementia
public
health
priority
due
its
high
prevalence
incidence.
The
aim
this
review
highlight
implications
neuroinflammation
characteristic
AD
pathology
subsequent
cognitive
impairment.
It
systematic
current
literature
obtained
by
searching
PubMed,
Web
Science
Scopus
databases.
intestinal
patients
leads
increased
permeability
barrier
activates
immune
cells
central
nervous
system
translocation
microbiota-derived
metabolites
and/or
bacteria
into
circulation
leading
neuronal
loss,
thus
generating
impairment
AD.
presence
Porphyromonas
gingivalis
beta-amyloid
peptide
accumulation.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2023,
Номер
13
Опубликована: Окт. 4, 2023
The
microbiota
gut
brain
(MGB)
axis
has
been
shown
to
play
a
significant
role
in
the
regulation
of
inflammatory
and
infective
diseases.
Exploring
structure
communication
mode
MGB
is
crucial
for
understanding
its
diseases,
studying
signaling
pathways
regulatory
methods
diseases
also
profound
significance
future
clinical
research.
This
article
reviews
composition,
mechanism
including
Parkinson’s
disease
(PD),
Alzheimer’s
(AD),
multiple
sclerosis
(MS),
autism
spectrum
disorder
(ASD),
depression,
psoriasis,
irritable
bowel
syndrome
(IBS),
(IBD).
In
addition,
our
investigation
delved
into
functions
inflammasome,
IFN-I,
NF-κB,
PARK7/DJ-1
innate
immune
pathway
context
Ultimately,
we
discussed
efficacy
various
interventions,
fecal
transplantation
(FMT),
antibiotics,
probiotics,
prebiotics,
synbiotics,
postbiotics,
management
Understanding
might
make
positive
effects
treatment
