Mitophagy in human health, ageing and disease

Nature Metabolism, Год журнала: 2023, Номер 5(12), С. 2047 - 2061

Опубликована: Ноя. 30, 2023

Язык: Английский

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Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Journal of Biomedical Science, Год журнала: 2023, Номер 30(1)

Опубликована: Окт. 12, 2023

Mitochondrial mass and quality are tightly regulated by two essential opposing mechanisms, mitochondrial biogenesis (mitobiogenesis) mitophagy, in response to cellular energy needs other environmental cues. Great strides have been made uncover key regulators of these complex processes. Emerging evidence has shown that there exists a tight coordination between mitophagy mitobiogenesis, their defects may cause many human diseases. In this review, we will first summarize the recent advances discovery molecular regulations mitobiogenesis then focus on mechanism signaling pathways involved simultaneous regulation tissue or cultured cells needs, stress, pathophysiological conditions. Further studies crosstalk processes at level provide better understanding how cell maintains optimal fitness function under physiological conditions, which holds promise for fighting aging aging-related

Язык: Английский

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AMPK and NRF2: Interactive players in the same team for cellular homeostasis?

Free Radical Biology and Medicine, Год журнала: 2022, Номер 190, С. 75 - 93

Опубликована: Июль 31, 2022

NRF2 (Nuclear factor E2 p45‐related 2) is a stress responsive transcription lending cells resilience against oxidative, xenobiotic, and also nutrient or proteotoxic insults. AMPK (AMP-activated kinase), considered as prime regulator of cellular energy homeostasis, not only tunes metabolism to provide the cell at any time with sufficient ATP building blocks, but controls redox balance inflammation. Due observed overlapping responses upon activation common stressors impinging on both signaling, it plausible assume that signaling may interdepend cooperate readjust homeostasis. After short introduction two players this narrative review paints current picture how might interact molecular level, highlights their possible crosstalk in selected examples pathophysiology bioactivity drugs phytochemicals.

Язык: Английский

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Mitochondrial Dysfunction, Oxidative Stress, and Therapeutic Strategies in Diabetes, Obesity, and Cardiovascular Disease

Antioxidants, Год журнала: 2023, Номер 12(3), С. 658 - 658

Опубликована: Март 7, 2023

Mitochondria are subcellular organelles involved in essential cellular functions, including cytosolic calcium regulation, cell apoptosis, and reactive oxygen species production. They the site of important biochemical pathways, tricarboxylic acid cycle, parts ureagenesis or haem synthesis. responsible for majority ATP production through OXPHOS. Mitochondrial dysfunction has been associated with metabolic pathologies such as diabetes, obesity, hypertension, neurodegenerative diseases, aging, cancer. In this article, we describe pathophysiological changes in, mitochondrial role of, disorders (diabetes, cardiovascular disease) their correlation oxidative stress. We highlight genetic identified at mtDNA level. Additionally, selected several representative biomarkers stress summarize progress therapeutic strategies.

Язык: Английский

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Mitochondrial and metabolic alterations in cancer cells

European Journal of Cell Biology, Год журнала: 2022, Номер 101(3), С. 151225 - 151225

Опубликована: Апрель 13, 2022

Metabolic alterations have been observed in many cancer types. The deregulated metabolism has thus become an emerging hallmark of the disease, where is frequently rewired to aerobic glycolysis. This led concept "metabolic reprogramming", which therefore extensively studied. Over years, it characterized enhancement glycolysis, key mutations some enzymes TCA cycle, and increased glucose uptake, are used by cells achieve a phenotype" useful gain proliferation advantage. Many studies highlighted detail signaling pathways molecular mechanisms responsible for glycolytic switch. However, glycolysis not only metabolic process that rely on. Oxidative Phosphorylation (OXPHOS), gluconeogenesis or beta-oxidation fatty acids (FAO) may be involved development progression several tumors. In cases, these metabolisms even more crucial than tumor survival. review will focus on contribution survival cancers. We also analyze balance between processes regulated, as well therapeutical approaches can derive from their study.

Язык: Английский

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Regulation of Mitophagy by Sirtuin Family Proteins: A Vital Role in Aging and Age-Related Diseases

Frontiers in Aging Neuroscience, Год журнала: 2022, Номер 14

Опубликована: Май 9, 2022

Sirtuins are protein factors that can delay aging and alleviate age-related diseases through multiple molecular pathways, mainly by promoting DNA damage repair, delaying telomere shortening, mediating the longevity effect of caloric restriction. In last decade, sirtuins have also been suggested to exert mitochondrial quality control mitophagy, which targets damaged mitochondria delivers them lysosomes for degradation. This is especially significant because dysfunctional accumulate in organisms. Accordingly, it has mitophagy many common interactive aspects process. article reviews mechanisms pathways sirtuin family-mediated further discusses its role diseases.

Язык: Английский

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Autophagy, Oxidative Stress, and Alcoholic Liver Disease: A Systematic Review and Potential Clinical Applications

Antioxidants, Год журнала: 2023, Номер 12(7), С. 1425 - 1425

Опубликована: Июль 14, 2023

Ethanol consumption triggers oxidative stress by generating reactive oxygen species (ROS) through its metabolites. This process leads to steatosis and liver inflammation, which are critical for the development of alcoholic disease (ALD). Autophagy is a regulated dynamic that sequesters damaged excess cytoplasmic organelles lysosomal degradation may counteract harmful effects ROS-induced stress. These include hepatotoxicity, mitochondrial damage, steatosis, endoplasmic reticulum stress, iron overload. In diseases, particularly ALD, macroautophagy has been implicated as protective mechanism in hepatocytes, although it does not appear play same role stellate cells. Beyond liver, autophagy also mitigate alcohol on other organs, thereby providing an additional layer protection against ALD. potential further supported studies showing drugs interact with autophagy, such rapamycin, can prevent ALD animal models. systematic review presents comprehensive analysis literature, focusing regulation, involvement organ-organ crosstalk relevant autophagy-targeting therapeutic strategies.

Язык: Английский

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A cross-talk between sestrins, chronic inflammation and cellular senescence governs the development of age-associated sarcopenia and obesity

Ageing Research Reviews, Год журнала: 2023, Номер 86, С. 101852 - 101852

Опубликована: Янв. 13, 2023

Язык: Английский

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Post‐translational regulation of muscle growth, muscle aging and sarcopenia

Journal of Cachexia Sarcopenia and Muscle, Год журнала: 2023, Номер 14(3), С. 1212 - 1227

Опубликована: Май 1, 2023

Abstract Skeletal muscle makes up 30–40% of the total body mass. It is great significance in maintaining digestion, inhaling and exhaling, sustaining posture, exercising, protecting joints many other aspects. Moreover, also an important metabolic organ that helps to maintain balance sugar fat. Defective skeletal function not only limits daily activities elderly but increases risk disability, hospitalization death, placing a huge burden on society healthcare system. Sarcopenia progressive decline mass, strength with age caused by environmental genetic factors, such as abnormal regulation protein post‐translational modifications (PTMs). To date, studies have shown numerous PTMs, phosphorylation, acetylation, ubiquitination, SUMOylation, glycosylation, glycation, methylation, S‐nitrosylation, carbonylation S‐glutathionylation, are involved health diseases. This article systematically summarizes growth atrophy understand pathophysiology aging develop effective strategies for diagnosing, preventing treating sarcopenia.

Язык: Английский

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Resveratrol activates autophagy and protects from UVA-induced photoaging in human skin fibroblasts and the skin of male mice by regulating the AMPK pathway

Biogerontology, Год журнала: 2024, Номер 25(4), С. 649 - 664

Опубликована: Апрель 9, 2024

Abstract Skin photoaging is mostly caused by ultraviolet A (UVA), although active medications to effectively counteract UVA-induced have not yet been created. Resveratrol, a naturally occurring polyphenol found in the skin of grapes, has shown various biological functions such as anti-inflammatory and antioxidant characteristics. However, role resveratrol clarified. We investigated mechanism action UVA irradiation human fibroblasts (HSF) innovatively modified mouse model photoaging. The results demonstrated that promoted AMP-activated protein kinase (AMPK) phosphorylation activate autophagy, reduce reactive oxygen species (ROS) production, inhibit apoptosis, restore normal cell cycle alleviate In addition, subcutaneous injection only improved symptoms roughness, erythema, increased wrinkles photodamaged mice, but also alleviated epidermal hyperkeratosis hyperpigmentation, reduced inflammatory responses, inhibited collagen fiber degradation. conclusion, our studies proved can treat elucidated possible molecular mechanisms involved, providing new therapeutic strategy for future anti-aging.

Язык: Английский

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