Engineering Pd atom membrane-nanoparticle on carbon nitride for efficient photocatalytic water disinfection via in situ generation and activation of H2O2

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161423 - 161423

Опубликована: Март 1, 2025

Язык: Английский

---

A Real Pandora’s Box in Pandemic Times: A Narrative Review on the Acute Cardiac Injury Due to COVID-19

Life, Год журнала: 2022, Номер 12(7), С. 1085 - 1085

Опубликована: Июль 20, 2022

The intricate relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the cardiovascular system is an extensively studied pandemic topic, as there ever-increasing amount of evidence that reports a high prevalence cardiac injury in context viral infection. In patients with Coronavirus disease 2019, COVID-19, significant increase serum levels troponin or other various biomarkers was observed, suggesting injury, thus predicting both course poor outcome. Pathogenesis not yet completely elucidated, though several mechanisms are allegedly involved, such direct cardiomyocyte oxygen supply-demand inequity caused by hypoxia, active myocardial depressant factors during sepsis, endothelial dysfunction due to hyperinflammatory status. Moreover, increased plasma cytokines catecholamines significantly enhanced prothrombotic environment may lead destabilization rupture atheroma plaques, subsequently triggering coronary syndrome. present review, we focus on describing epidemiology, pathogenesis, role diagnosis prognosis setting COVID-19 pandemic. We also explore some novel therapeutic strategies involving immunomodulatory therapy, well their preventing form disease, short-term outcome long-term sequelae being equally important SARS-CoV-2 induced injury.

Язык: Английский

---

Association of Interleukin-32 and Interleukin-34 with Cardiovascular Disease and Short-Term Mortality in COVID-19

Journal of Clinical Medicine, Год журнала: 2023, Номер 12(3), С. 975 - 975

Опубликована: Янв. 27, 2023

Excess cardiovascular (CV) morbidity and mortality has been observed in patients with COVID-19. Both interleukin-32 (IL-32) interleukin-34 (IL-34) have hypothesized to contribute CV involvement COVID-19.This prospective, observational study of laboratory-confirmed COVID-19 infection was conducted from 6 June 22 December 2020 a tertiary care hospital Vienna, Austria. IL-32 IL-34 levels on admission were collected tested for their association disease short-term defined by the presence coronary artery disease, heart failure, stroke or atrial fibrillation stratified burden.A total 245 eligible included, whom 37 (15.1%) reached primary endpoint 28-day mortality. Of sample, 161 had no (65.7%), 69 one two diseases (28.2%) 15 ≥three (6.1%). Median at comparable across three groups burden. failed predict upon both univariable multivariable Cox regression analysis. The groups, however, significantly higher risk within 28 days (one diseases: crude HR 4.085 (95% CI, 1.913-8.725), p < 0.001 13.173 5.425-31.985), 0.001). This persisted those after adjustment age, gender factors (adjusted 3.942 1.288-12.068), = 0.016).In our population hospitalized COVID-19, did not show any associations context Patients multiple diseases, increased

Язык: Английский

---

Quantification of hs-Troponin Levels and Global Longitudinal Strain among Critical COVID-19 Patients with Myocardial Involvement

Journal of Clinical Medicine, Год журнала: 2024, Номер 13(2), С. 352 - 352

Опубликована: Янв. 8, 2024

Background. Myocardial involvement among critically ill patients with coronavirus disease 2019 (COVID-19) often has worse outcomes. An imbalance in the oxygen supply causes excessive release of pro-inflammatory cytokines, which results increased ventilation requirements and risk death COVID-19 patients. Purpose. We evaluated association between hs-troponin I levels global longitudinal strain (GLS) as evidence myocardial critical Methods. conducted a prospective cohort study from 1 February to 31 July 2021 at RSUD Dr. Soetomo, Surabaya, referral center. Of 65 included, 41 (63.1%) were men, median age (interquartile range) 51.0 years (20.0-75.0). Subjects recruited based on WHO criteria for severe COVID-19, form myocarditis was assessed using CDC criteria. examined echocardiography measure GLS, blood samples taken hs-troponin. then followed their need mechanical in-hospital mortality. Results. Severe cardiac injury associated an intubation (78.5%) incidence (50.8%). There relationship use (66.7% vs. 33.3%, p-value < 0.001). Decreased GLS (p values 0.001 0.004, respectively). higher (12.17 + 4.79 15.65 4.90, = 0.02) mortality (11.36 4.64 14.74 4.82; 0.005). Elevated (25.33% 3.56%, 0.002) (34.57% 5.76%, 0.002). Conclusions. Critically elevated troponin are

Язык: Английский

---

Lessons from SARS-CoV, MERS-CoV, and SARS-CoV-2 Infections: What We Know So Far

Canadian Journal of Infectious Diseases and Medical Microbiology, Год журнала: 2022, Номер 2022, С. 1 - 13

Опубликована: Авг. 12, 2022

Within past decades, human infections with emerging and reemerging zoonotic viral pathogens have raised the eminent public health concern. Since November 2002, three highly pathogenic major deadly coronaviruses of βετα-genera (β-hCoVs), namely, severe acute respiratory distress syndrome-coronavirus (SARS-CoV), middle east (MERS-CoV), SARS-CoV-2, been globally emerged culminated in occurrence SARS epidemic, MERS outbreak, coronavirus disease 19 (COVID-19) pandemic, respectively. The global emergence spread these β-hCoVs extremely dreadful impacts on become an economic burden. Unfortunately, clear specific efficient medical countermeasures for their underlying fatal illnesses remain under development. Although they belong to same family share many features convergent evolution, some important obvious differences. By utilizing lessons gaining a deeper understanding β-hCoVs, we can identify areas improvement provide preparedness plans fighting controlling future that might arise from them or other potential hCoVs. Therefore, this review summarizes state-of-the-art information compares similarities dissimilarities between SARS-CoV, MERS-CoV, terms evolution trait, genome organization, host cell entry mechanisms, tissue infectivity tropisms, transmission routes contagiousness, clinical characteristics, laboratory features, immunological abnormalities related illnesses. It also provides overview SARS-CoV-2 variants. Additionally, it discusses challenges most proposed treatment options infections.

Язык: Английский

---

Measurement of Cardiac-Specific Biomarkers in the Emergency Department: New Insight in Risk Evaluation

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(21), С. 15998 - 15998

Опубликована: Ноя. 6, 2023

The aim of this article review is to analyze some models and clinical issues related the implementation accelerated diagnostic protocols based on specific cardiac biomarkers in patients admitted emergency department (ED) with symptoms compatible acute disorders. Four will be discussed detail: (a) pathophysiological interpretations circulating hs-cTnI hs-cTnT levels; (b) relevance estimation biological variation ED severe diseases; (c) role advantages point-of-care testing (POCT) methods for cardiac-specific pre-hospital hospital practice; (d) heart failure (AHF). In order balance risk between a hasty discharge versus potential harms caused by assessment suspected cardiovascular disease, measurement essential early identification presence myocardial dysfunction and/or injury significantly reduce length costs hospitalization. Moreover, (especially hs-cTnT) are useful predictors mortality major adverse events (MACE) disease. To guide most rapid algorithms diagnosis Non-ST-Elevation Myocardial Infarction (NSTEMI) into routine practice, scientific societies laboratory medicine should promote collaborative studies specifically designed evaluation analytical performance and, especially, cost/benefit ratio resulting from use these POCT practice.

Язык: Английский

---

Common Prognostic Biomarkers and Outcomes in Patients with COVID-19 Infection in Saudi Arabia

Tropical Medicine and Infectious Disease, Год журнала: 2023, Номер 8(5), С. 260 - 260

Опубликована: Апрель 30, 2023

Background: COVID-19 is a respiratory disease that eventually became pandemic, with 300 million people infected around the world. Alongside improvement in management and vaccine development, identifying biomarkers for has recently been reported to help early prediction managing severe cases, which might improve outcomes. Our study aimed find out if there any correlation between clinical severity elevated hematological biochemical markers patients its effect on outcome. Methods: We have collected retrospective data socio-demographics, medical history, biomarkers, outcomes from five hospitals health institutions Kingdom of Saudi Arabia. Results: Pneumonia was most common presentation our cohort. The presence abnormal inflammatory (D-dimer, CRP, troponin, LDH, ferritin, t white blood cells) significantly associated unstable disease. In addition, evidence disease, particularly those who required mechanical ventilation, had higher when compared stable conditions (p < 0.001). Conclusion: Identifying predicts may their management.

Язык: Английский

---

Temporal patterns of cytokine and injury biomarkers in hospitalized COVID-19 patients treated with methylprednisolone

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Авг. 16, 2023

The novel coronavirus disease 2019 (COVID-19) presents with complex pathophysiological effects in various organ systems. Following the COVID-19, there are shifts biomarker and cytokine equilibrium associated altered physiological processes arising from viral damage or aggressive immunological response. We hypothesized that high daily dose methylprednisolone improved injury biomarkers serum profiles COVID-19 patients. Injury analysis was performed on 50 SARS-Cov-2 negative controls 101 hospitalized severe patients: 49 methylprednisolone-treated (MP group) 52 placebo-treated samples. Samples treated groups collected days D1 (pre-treatment) all groups, D7 (2 after ending therapy) D14 were analyzed. Luminex assay quantified HMGB1, FABP3, myoglobin, troponin I NTproBNP. Immune mediators (CXCL8, CCL2, CXCL9, CXCL10, TNF, IFN-γ, IL-17A, IL-12p70, IL-10, IL-6, IL-4, IL-2, IL-1β) using cytometric bead array. At pretreatment, two treatment comparable demographically. pre-treatment (D1), (HMGB1, TnI, myoglobin FABP3) distinctly elevated. D7, HMGB1 significantly higher MP group (p=0.0448) compared to placebo group, while diminished by (p=0.0115). Compared healthy control samples, several immune (IL-17A, MIG, MCP-1, IP-10) considerably elevated at baseline (all p≤0.05). MIG IP-10 of MP-group lower than placebo-group (p=0.0431, p=0.0069, respectively). Longitudinally, IL-2 (MP-group) IL-17A (placebo-group) had increased D14. In continuously increased, as IL-10 steadily decreased during follow-up. IL-12p70 progressively increase IL-1β gradually towards Moderate strong positive correlations between chemokines cytokines observed These findings suggest could ameliorate levels but appeared have no impact TnI addition, relieves induced inflammatory response diminishing levels. Overall, corticosteroid (methylprednisolone) use management influences molecule profile

Язык: Английский

---

Correlations and Algorithmization of Cytokine Status Analysis of Patients with Coronary Heart Disease in the Early Recovery Period After COVID-19

Proceedings of the Southwest State University Series IT Management Computer Science Computer Engineering Medical Equipment Engineering, Год журнала: 2024, Номер 13(3), С. 8 - 20

Опубликована: Янв. 27, 2024

The purpose of research is study correlations and algorithmization cytokine status analysis patients with coronary heart disease in the early recovery period after COVID-19. Methods . Cytokine was studied 40 3-4 weeks from COVID19. control consisted 38 without level cytokines blood determined on device "Becton Dickinson FACS Canto 2 (USA)". Correlation regression were used statistical analysis. Results Reliable moderate established between IL-6 IL-2, IL-3, respectively, r = 0,35 0,33; IL-17 IL-2 – 0,28 0,63, respectively; TNF-α IFN-γ 0,42 0,39. At same time, greatest association, according to values correlation coefficients, among interleukins during convalescence characteristic IL-6. However, also had a significant number under consideration. All this indicates high association IL-6, other COVID-19 their priority participation development these patients. To identify most informative cytokines, an algorithm for analyzing has been developed, which provides uncorrected adjusted mathematical models by gender age who have undergone It found that effect (OR 1,792, p 0,0021) model 1,708, 0,0012). Conclusion correlations, algorithms created are proposed be assessing thedynamics

Язык: Английский

---

A Narrative Review of the Evaluation of Biomarkers in COVID-19 Patients Indicating the Course of the Disease

Turkiye Klinikleri Journal of Medical Sciences, Год журнала: 2024, Номер 44(1), С. 43 - 52

Опубликована: Янв. 1, 2024

The global spread of the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) virus has led to a widespread outbreak coronavirus disease-2019 (COVID-19), resulting in pandemic. Following end pandemic, COVID-19 transitioned into an endemic phase characterized by anticipated periodic surges. Therefore, development readily available prognostic biomarkers for patients continues be crucial field study. Monitoring blood with is component patient care. it necessary conduct hematological assessments such as leukocyte count, lymphocyte neutrophil neutrophil-lymphocyte ratio, and thrombocyte count. Additionally, inflammatory markers C-reactive protein, erythrocyte sedimentation rate, procalcitonin should measured. Immunological indicators including interleukin-6 tumor necrosis factor-α also evaluated. Furthermore, biochemical tests aspartate aminotransferase, alanine urea, creatinine, troponin levels assessed. Lastly, coagulation parameters D-dimer, fibrin degradation products, examined. objective this narrative review assess that have potential valuable monitoring progression management COVID-19. Studies published between 2020 2023 scanned PubMed, Ebsco Google Scholar were used analysis. Keywords ''COVID19'', ''SARS-CoV2'', ''biomarkers'' ''severe SARS-CoV-2 infection'' restrict search.

Язык: Английский

---