Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Март 8, 2025
CNS
diseases
account
for
a
major
part
of
the
comorbidity
and
mortality
human
population;
moreover,
neuroinflammation
has
become
an
indication
different
diseases,
instance,
Parkinson's
Alzheimer's
disease.
Microglia
astrocytes
are
two
main
glial
cells
that
can
be
found
in
CNS.
Each
these
plays
important
role
mediating
immune
responses
like
inflammation.
There
many
studies
suggesting
LncRNAs
neuroinflammation.
Indeed,
orchestrate
through
various
mechanisms,
namely
miRNA
sponge,
transcriptional
activation/inhibition.
In
addition,
regulate
downstream
pathways
NF-κB,
PI3K/AKT.
this
study,
we
gathered
existing
regarding
mechanisms
action
pathogenesis
neurodegenerative
traumatic
injuries
regulating
We
aim
to
elaborate
on
regulatory
roles
bring
more
profound
understanding
etiology
terms
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 29, 2025
Neurodegenerative
diseases,
characterized
by
progressive
neuronal
loss
and
cognitive
impairments,
pose
a
significant
global
health
challenge.
This
study
explores
the
potential
of
nanotherapeutics
as
promising
approach
to
enhance
drug
delivery
across
physiological
barriers,
particularly
blood–brain
barrier
(BBB)
blood-cerebrospinal
fluid
(B-CSFB).
By
employing
nanoparticles,
this
research
aims
address
critical
challenges
in
diagnosis
treatment
conditions
such
Alzheimer’s,
Parkinson’s,
Huntington’s
diseases.
The
multifactorial
nature
these
disorders
necessitates
innovative
solutions
that
leverage
nanomedicine
improve
solubility,
circulation
time,
targeted
while
minimizing
off-target
effects.
findings
underscore
importance
advancing
applications
develop
effective
therapeutic
strategies
can
alleviate
burden
neurodegenerative
diseases
on
individuals
healthcare
systems.
Heliyon,
Год журнала:
2025,
Номер
unknown, С. e42349 - e42349
Опубликована: Янв. 1, 2025
Early
detection
of
Alzheimer's
disease
is
essential
for
effective
treatment
and
the
development
therapies
that
modify
progression.
Developing
sensitive
specific
noninvasive
diagnostic
tools
crucial
improving
clinical
outcomes
advancing
our
understanding
this
condition.
Liquid
biopsy
techniques,
especially
those
involving
plasma
biomarkers,
provide
a
promising
method
early
diagnosis
monitoring.
In
study,
we
analyzed
proteomic
profiles
38
healthy
individuals,
with
an
average
age
66.5
years,
22
patients
disease,
79.7
years.
Proteins
in
were
quantified
using
specialized
panels
designed
extension
assays.
Through
computational
analysis
linear
support
vector
machine
algorithm,
identified
82
differentially
expressed
proteins
between
two
groups.
From
these,
calculated
6642
possible
protein
ratios
combinations
these
as
significant
features
distinguishing
individuals
individuals.
Notably,
kynureninase
to
macrophage
scavenger
receptor
type
1,
Neurocan
protogenin,
interleukin-5
alpha
glial
cell
line-derived
neurotrophic
factor
1
achieving
accuracy
up
98
%
differentiating
This
study
underscores
potential
leveraging
relationships,
ratios,
diagnostics.
Furthermore,
findings
highlight
promise
liquid
techniques
accurate
approach
monitoring
blood
plasma.
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 284 - 284
Опубликована: Фев. 20, 2025
Cognitive
aging,
characterized
by
the
gradual
decline
in
cognitive
functions
such
as
memory,
attention,
and
problem-solving,
significantly
impacts
daily
life.
This
is
often
accelerated
neurodegenerative
diseases,
particularly
Alzheimer’s
Disease
(AD)
Parkinson’s
(PD).
AD
marked
accumulation
of
amyloid-beta
plaques
tau
tangles,
whereas
PD
involves
degeneration
dopaminergic
neurons.
Both
conditions
lead
to
severe
impairment,
greatly
diminishing
quality
life
for
affected
individuals.
Recent
advancements
regenerative
medicine
have
highlighted
mesenchymal
stromal
cells
(MSCs)
their
derived
exosomes
promising
therapeutic
options.
MSCs
possess
regenerative,
neuroprotective,
immunomodulatory
properties,
which
can
promote
neurogenesis,
reduce
inflammation,
support
neuronal
health.
Exosomes,
nanosized
vesicles
from
MSCs,
provide
an
efficient
means
delivering
bioactive
molecules
across
blood–brain
barrier,
targeting
underlying
pathologies
PD.
While
these
therapies
hold
great
promise,
challenges
variability
MSC
sources,
optimal
dosing,
effective
delivery
methods
need
be
addressed
clinical
application.
The
development
robust
protocols,
along
with
rigorous
trials,
crucial
validating
safety
efficacy
exosome
therapies.
Future
research
should
focus
on
overcoming
barriers,
optimizing
treatment
strategies,
exploring
integration
lifestyle
interventions.
By
addressing
challenges,
MSC-
exosome-based
could
offer
transformative
solutions
improving
outcomes
enhancing
individuals
aging
diseases.
SLAS TECHNOLOGY,
Год журнала:
2025,
Номер
unknown, С. 100257 - 100257
Опубликована: Фев. 1, 2025
Alzheimer's
disease
(AD)
is
a
progressive
neurological
condition
characterized
by
cognitive
decline,
memory
loss,
and
aberrant
behaviour.
It
affects
millions
of
people
globally
one
the
main
causes
dementia.
The
neurodegenerative
known
as
AD
has
intricate,
multifaceted
mechanisms
that
make
it
difficult
to
comprehend
identify
in
its
early
stages.
Conventional
diagnostic
techniques
frequently
fail
detect
By
combining
Natural
Language
Processing
(NLP)
Large
Models
(LLMs),
this
research
suggests
novel
approach
for
identifying
potential
biomarkers
underlying
AD.
Clinical
data
gathered
from
publicly
accessible
databases
healthcare
facilities,
including
genetic
information,
neuroimaging
scans,
medical
records.
pre-processing
unstructured
clinical
notes
involves
tokenization
profiles
are
normalized
Z-score
normalization
consistency.
Multi-Input
Convolutional
Neural
Networks
(MI-CNN)
employed
efficiently
fuse
diverse
sources,
allowing
thorough
analysis.
Key
linked
identified
categorized
using
Genetic
Algorithm
combined
with
Bidirectional
Encoder
Representations
Transformers
(BERT)
(GenBERT).
fine-tuning
BERT's
hyperparameters
optimization
approaches,
GenBERT
enables
effective
analysis
large
datasets,
such
patient
histories,
data,
notes.
combination
strategy
increases
feature
selection
model's
capacity
minute
genomic
linguistic
patterns
suggestive
goal
integrated
provide
tools
new
insights
into
pathogenesis
disease,
which
could
transform
methods
detecting
treating
As
concerns
prediction,
model
performs
better
than
current
techniques,
obtaining
highest
accuracy
(98.30%)
F1-score
(0.97),
well
greater
precision
(0.95)
recall
(0.92).
Additionally,
demonstrates
reliably
both
positive
negative
cases
sensitivity
(98.65%)
specificity
(99.73%).
Overall,
offers
trustworthy
useful
tool
diagnosis.
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Март 8, 2025
CNS
diseases
account
for
a
major
part
of
the
comorbidity
and
mortality
human
population;
moreover,
neuroinflammation
has
become
an
indication
different
diseases,
instance,
Parkinson's
Alzheimer's
disease.
Microglia
astrocytes
are
two
main
glial
cells
that
can
be
found
in
CNS.
Each
these
plays
important
role
mediating
immune
responses
like
inflammation.
There
many
studies
suggesting
LncRNAs
neuroinflammation.
Indeed,
orchestrate
through
various
mechanisms,
namely
miRNA
sponge,
transcriptional
activation/inhibition.
In
addition,
regulate
downstream
pathways
NF-κB,
PI3K/AKT.
this
study,
we
gathered
existing
regarding
mechanisms
action
pathogenesis
neurodegenerative
traumatic
injuries
regulating
We
aim
to
elaborate
on
regulatory
roles
bring
more
profound
understanding
etiology
terms
