International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16469 - 16469
Опубликована: Ноя. 17, 2023
Polyamines
(Pas)
are
short
molecules
that
exhibit
two
or
three
amine
groups
positively
charged
at
a
physiological
pH.
These
small
present
in
high
concentrations
wide
variety
of
organisms
and
tissues,
suggesting
they
play
an
important
role
cellular
physiology.
include
spermine,
spermidine,
putrescine,
which
roles
age-related
diseases
have
not
been
completely
elucidated.
Aging
is
natural
process,
defined
as
the
time-related
deterioration
functions;
it
considered
risk
factor
for
degenerative
such
cardiovascular,
neurodegenerative,
musculoskeletal
diseases;
arthritis;
even
cancer.
In
this
review,
we
provide
new
perspective
on
participation
Pas
molecular
processes
related
to
diseases,
focusing
our
attention
Alzheimerߣs
disease,
Parkinsonߣs
osteoarthritis,
sarcopenia,
osteoporosis.
This
leads
us
propose
function
novel
biomarkers
with
main
purpose
achieving
alternatives
healthier
aging.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 10, 2025
Sarcopenia
is
a
disease
characterized
by
decreasing
muscle
mass
and
strength
or
performance.
The
prevalence
of
sarcopenia
in
rheumatic
diseases
has
been
evaluated
single
using
various
diagnostic
approaches,
generating
conflicting
data.
study
aims
to
investigate
young
adults
with
inflammatory
arthritis
(IA)
detect
factors
associated
low
strength.
single-center,
cross-sectional
included
138
IA.
Dynamometry
Jamar
hand
dynamometer
was
used
determine
handgrip
Thresholds
for
reduced
were
<
27
kg
males
16
females.
To
skeletal
index
(SMI),
dual
photon
X-ray
absorptiometry
(DXA)
done
such
cut-off
points
5.67
kg/m2
females
7.0
males.
Patients
both
considered
as
sarcopenic.
Logistic
regression
analyses
estimated
between
factors.
Statistical
significance
defined
p-value
0.05.
about
47%
all
IA
significantly
different
juvenile
idiopathic
(JIA),
spondyloarthritis
(SpA),
rheumatoid
(RA)
groups
(p
=
0.006).
At
multivariable
analysis,
body
(BMI)
(OR
0.84;
CI
95%
0.72–0.86,
p
0.02),
bone
mineral
density
(BMD)
at
femur
neck
0.01;
0.001–0.268,
0.01),
25-hydroxyvitamin
D
(25(OH)D)
0.96;
0.93–0.98,
0.001),
disability
Health
Assessment
Questionnaire
(HAQ)
14.54;
4.92–51.77,
0.001)
increased
risk
sarcopenia.
results
our
demonstrate
high
among
patients
In
these
participants,
lower
BMI,
BMD,
25(OH)D
concentration,
higher
HAQ
linked
Deleted Journal,
Год журнала:
2025,
Номер
2(1), С. 16 - 23
Опубликована: Янв. 9, 2025
Background:
The
occurrence
of
sarcopenia
escalates
swiftly
as
age
advances.
Both
lipopolysaccharide
(LPS)
and
a
prolonged
high-fat
diet
(HFD)
can
trigger
skeletal
muscle
wasting,
yet
the
combined
impact
these
2
factors
remains
an
enigma.
Objective:
To
present
animal
model
induced
by
LPS
HFD
in
rats.
Methods:
We
divided
10-month-old
male
Sprague-Dawley
(SD)
rats
into
control
group,
low-dose
(150
µg/kg)-HFD
group
(LD-LPS-HFD),
high-dose
(200
(HD-LPS-HFD).
Control
were
intraperitoneally
injected
with
0.9%
physiological
saline
solution
fed
ordinary
feed,
while
LPS-HFD
groups
twice
week
had
for
8
weeks.
Sarcopenia
Index,
relative
grip
strength,
hematoxylin
eosin
staining,
Sirius
red
western
blotting,
enzyme-linked
immunosorbent
assay
verified
sarcopenia.
Results:
Index
values
LD-LPS-HFD
HD-LPS-HFD
significantly
decreased,
differences
more
than
SD
indicating
that
was
successful.
Although
strength
reduced,
only
difference
which
consistent
characteristics
decline
Cross-sectional
areas
fiber
diameters
decreased
but
lower
HD-LPS-HFD.
Fibrosis,
MuRF1,
FbX32,
p53
protein
expression
increased
higher
p21,
interleukin
6,
tumor
necrosis
factor-alpha
levels
Conclusion:
study
shows
intervention
200
µg/kg
injections
weeks
middle-aged
effectively
mimics
sarcopenia,
causing
mass
loss,
cellular
atrophy,
interstitial
infiltration,
inflammation,
aging
marker
expression.
Menopause The Journal of The North American Menopause Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 18, 2025
Abstract
Objective
Little
is
known
about
the
longitudinal
associations
between
creatinine-cystatin
C
ratios
(CCR)
with
muscle
volume
and
function
during
menopausal
transition.
We
investigated
relationship
of
baseline
CCR,
volumes
measured
by
magnetic
resonance
imaging
(MRI),
objectively
strength
physical
performance
after
6.6-year
follow-up.
Methods
Participants
from
Integrated
Women's
Health
Programme
(IWHP)
cohort
(n
=
891,
mean
age
56.2
±
6.0)
who
attended
both
follow-up
visits
underwent
assessments
MRI.
Creatinine
to
cystatin
ratio
was
calculated
as
(creatinine
[mg/dL]
/
[mg/L])
low
CCR
were
those
in
lowest
tertile
(CCR
<
8.16).
Multivariable
regression
analyses
used
determine
6.6
years
later.
Results
Baseline
associated
lower
MRI-measured
poorer
Compared
high
group,
fat-free
thigh
group
0.350
L
(95%
CI,
0.183‐0.518)
adjustment
for
covariates.
Similarly,
0.029
m/s
slower
0.006‐0.053)
usual
gait
0.049
0.020‐0.078)
narrow
speeds.
not
handgrip
repeated
chair
stands
one-leg
stand
tests.
Conclusion
Low
at
speeds
The
potential
a
predictive
biomarker
adverse
events
related
sarcopenia
midlife
women
merits
further
investigation.
BioScience Trends,
Год журнала:
2023,
Номер
17(4), С. 293 - 301
Опубликована: Авг. 10, 2023
Sarcopenia
is
an
age-associated
skeletal
muscle
disease
characterized
by
the
progressive
loss
of
mass
and
function.
The
objective
this
systematic
review
meta-analysis
was
to
evaluate
associations
between
sarcopenia
cardio-cerebrovascular
(CCVD).
A
comprehensive
search
PubMed/Medline,
Embase,
Web
Science,
Scopus,
Cochrane
Library
databases
conducted
from
their
inception
April
1st,
2023.
total
eight
cross-sectional
studies
involving
63,738,162
participants
met
inclusion
criteria.
Pooled
estimates
odds
ratios
(ORs)
were
calculated
using
random-effects
models.
findings
demonstrated
a
significant
association
increased
risk
CCVD
(OR:
1.33,
95%
CI:
1.18
-
1.50,
I2
=
1%;
p
<
0.001).
Subgroup
analyses
indicated
that
associated
with
1.67-fold
increase
in
stroke
1.31-fold
CVD.
Four
included
examined
sarcopenic
obesity
CCVD,
results
revealed
higher
1.64,
1.08
2.49,
69%;
Meta-regressions
sensitivity
consistently
supported
robustness
overall
findings.
In
conclusion,
are
significantly
elevated
developing
CCVD.
However,
further
prospective
cohort
warranted
validate
relationship
while
controlling
for
confounding
factors.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(22), С. 16469 - 16469
Опубликована: Ноя. 17, 2023
Polyamines
(Pas)
are
short
molecules
that
exhibit
two
or
three
amine
groups
positively
charged
at
a
physiological
pH.
These
small
present
in
high
concentrations
wide
variety
of
organisms
and
tissues,
suggesting
they
play
an
important
role
cellular
physiology.
include
spermine,
spermidine,
putrescine,
which
roles
age-related
diseases
have
not
been
completely
elucidated.
Aging
is
natural
process,
defined
as
the
time-related
deterioration
functions;
it
considered
risk
factor
for
degenerative
such
cardiovascular,
neurodegenerative,
musculoskeletal
diseases;
arthritis;
even
cancer.
In
this
review,
we
provide
new
perspective
on
participation
Pas
molecular
processes
related
to
diseases,
focusing
our
attention
Alzheimerߣs
disease,
Parkinsonߣs
osteoarthritis,
sarcopenia,
osteoporosis.
This
leads
us
propose
function
novel
biomarkers
with
main
purpose
achieving
alternatives
healthier
aging.
