Molecular Cancer Therapeutics,
Год журнала:
2024,
Номер
23(11), С. 1586 - 1596
Опубликована: Июль 23, 2024
Abstract
Surgical
resection
followed
by
radiotherapy
(RT)
is
recommended
for
malignant
meningioma,
but
poor
outcome
unavoidable.
To
improve
the
efficacy
of
RT
in
a
targeted
radiosensitizer
can
be
added.
Nicotinamide
phosphoribosyltransferase
(NAMPT),
highly
expressed
high-grade
meningiomas,
may
play
role
determining
radioresponse.
Herein,
we
evaluated
impact
NAMPT
inhibition
on
radiosensitivity
meningioma
vivo
and
vitro.
IOMM-Lee
TTMM705
cells
were
treated
with
(FK866
or
shRNA
NAMPT)
before
irradiation.
The
subsequent
clonogenic
assay
demonstrated
significantly
increased
radiosensitivity.
Combination
treatment
FK866
irradiation
number
G2/M-phase
cells,
percentage
apoptotic
γ-H2A.X
level
compared
alone.
We
examined
effect
NMI
p53
expression
cells.
NMI,
p53,
CDKN1A
BAX
expression.
Additionally,
assessed
FK866/RT
combination
vivo.
exhibited
antitumor
either
Ki67
was
lower,
levels
higher
group
than
other
three
groups.
In
conclusion,
these
results
indicate
that
improves
an
attributed
to
increase
Cancers,
Год журнала:
2024,
Номер
16(17), С. 3085 - 3085
Опубликована: Сен. 5, 2024
Nicotinamide
adenine
dinucleotide
(NAD+)
is
an
important
cofactor
for
both
metabolic
and
signaling
pathways,
with
the
dysregulation
of
NAD+
levels
acting
as
a
driver
diseases
such
neurodegeneration,
cancers,
diseases.
plays
essential
role
in
regulating
growth
progression
cancers
by
controlling
cellular
processes
including
metabolism,
transcription,
translation.
regulates
several
pathways
glycolysis,
citric
acid
(TCA)
cycle,
oxidative
phosphorylation,
fatty
oxidation
redox
reactions.
Additionally,
acts
ADP-ribosyl
transferases
sirtuins,
well
ADP-ribosylation
deacetylation
levels,
respectively.
The
cleavage
CD38—an
hydrolase
expressed
on
immune
cells—produces
immunosuppressive
metabolite
adenosine.
As
result,
metabolizing
maintaining
remain
crucial
function
various
cells
found
tumor
microenvironment,
hence
its
critical
tissue
homeostasis.
are
maintained
balance
between
biosynthesis
consumption,
synthesis
being
controlled
Preiss–Handler,
de
novo,
salvage
pathways.
primary
source
variety
cell
types
directed
expression
enzymes
central
to
three
In
this
review,
we
describe
metabolism
synthesizing
consuming
enzymes’
control
cancer
responses
gynecologic
cancers.
review
ongoing
efforts
therapeutically
target
homeostasis
ABSTRACT
The
study
of
nicotinamide
adenine
dinucleotide
(NAD
+
)
biology
has
gained
popularity
recently.
Research
discovered
that
two
NAD
biosynthesis
intermediates,
riboside
(NR)
and
mononucleotide
(NMN),
are
biosynthetic
precursors
,
an
essential
chemical
for
metabolism.
Many
studies
show
levels
fall
considerably
with
aging,
regeneration
in
aging
animals
increasing
longevity
enhancing
health.
According
to
research
on
the
molecules,
NMN
NR,
supplementation
either
raises
during
aging.
objective
this
review
is
highlight
current
developments
relation
NR
or
supplement.
This
highlightings
significant
discoveries
about
biological
activities
health
benefits.
Molecular Cancer Therapeutics,
Год журнала:
2024,
Номер
23(11), С. 1586 - 1596
Опубликована: Июль 23, 2024
Abstract
Surgical
resection
followed
by
radiotherapy
(RT)
is
recommended
for
malignant
meningioma,
but
poor
outcome
unavoidable.
To
improve
the
efficacy
of
RT
in
a
targeted
radiosensitizer
can
be
added.
Nicotinamide
phosphoribosyltransferase
(NAMPT),
highly
expressed
high-grade
meningiomas,
may
play
role
determining
radioresponse.
Herein,
we
evaluated
impact
NAMPT
inhibition
on
radiosensitivity
meningioma
vivo
and
vitro.
IOMM-Lee
TTMM705
cells
were
treated
with
(FK866
or
shRNA
NAMPT)
before
irradiation.
The
subsequent
clonogenic
assay
demonstrated
significantly
increased
radiosensitivity.
Combination
treatment
FK866
irradiation
number
G2/M-phase
cells,
percentage
apoptotic
γ-H2A.X
level
compared
alone.
We
examined
effect
NMI
p53
expression
cells.
NMI,
p53,
CDKN1A
BAX
expression.
Additionally,
assessed
FK866/RT
combination
vivo.
exhibited
antitumor
either
Ki67
was
lower,
levels
higher
group
than
other
three
groups.
In
conclusion,
these
results
indicate
that
improves
an
attributed
to
increase
