Frontiers in Cell and Developmental Biology,
Год журнала:
2023,
Номер
11
Опубликована: Июнь 7, 2023
Parkinson’s
disease
(PD)
is
a
common
neurodegenerative
disorder
caused
by
genetic,
epigenetic,
and
environmental
factors.
Recent
advance
in
genomics
epigenetics
have
revealed
epigenetic
mechanisms
PD.
These
modifications
include
DNA
methylation,
post-translational
histone
modifications,
chromatin
remodeling,
RNA-based
mechanisms,
which
regulate
cellular
functions
almost
all
cells.
Epigenetic
alterations
are
involved
multiple
aspects
of
neuronal
development
neurodegeneration
In
this
review,
we
discuss
current
understanding
the
that
gene
expression
neural
degeneration
then
highlight
emerging
targets
diagnostic
therapeutic
biomarkers
for
treating
or
preventing
Biomolecules,
Год журнала:
2024,
Номер
14(1), С. 118 - 118
Опубликована: Янв. 16, 2024
Neurodegenerative
disorders,
such
as
Parkinson’s
disease,
Alzheimer’s
and
Huntington’s
are
identified
characterized
by
the
progressive
loss
of
neurons
neuronal
dysfunction,
resulting
in
cognitive
motor
impairment.
Recent
research
has
shown
importance
PTMs,
phosphorylation,
acetylation,
methylation,
ubiquitination,
sumoylation,
nitration,
truncation,
O-GlcNAcylation,
hydroxylation,
progression
neurodegenerative
disorders.
PTMs
can
alter
protein
structure
function,
affecting
stability,
localization,
interactions,
enzymatic
activity.
Aberrant
lead
to
misfolding
aggregation,
impaired
degradation,
clearance,
ultimately,
dysfunction
death.
The
main
objective
this
review
is
provide
an
overview
involved
neurodegeneration,
their
underlying
mechanisms,
methods
isolate
potential
therapeutic
targets
for
these
discussed
article
include
tau
α-synuclein
Huntingtin
histone
acetylation
RNA
modifications.
Understanding
role
diseases
may
new
strategies
devastating
Current Alzheimer Research,
Год журнала:
2024,
Номер
21(1), С. 24 - 49
Опубликована: Янв. 1, 2024
Abstract::
Microtubule-Associated
Protein
Tau
(also
known
as
tau)
has
been
shown
to
accumulate
into
paired
helical
filaments
and
neurofibrillary
tangles,
which
are
hallmarks
of
Alzheimer’s
disease
(AD)
pathology.
Decades
research
have
that
tau
protein
undergoes
extensive
post-translational
modifications
(PTMs),
can
alter
the
protein's
structure,
function,
dynamics
impact
various
properties
such
solubility,
aggregation,
localization,
homeostasis.
There
is
a
vast
amount
information
describing
role
different
PTMs
in
AD
pathology
neuroprotection.
However,
complex
interplay
between
these
remains
elusive.
Therefore,
this
review,
we
aim
comprehend
key
occurring
summarize
potential
connections
clarify
their
on
physiology
pathophysiology
tau.
Further,
describe
how
computational
modeling
methods
helped
understanding
structure
functions
protein.
Finally,
highlight
PTM-related
therapeutics
strategies
explored
for
development
therapy.
Pharmacological Research,
Год журнала:
2024,
Номер
203, С. 107182 - 107182
Опубликована: Апрель 12, 2024
Inflammatory
diseases,
including
infectious
diabetes-related
arthritis-related
neurological
digestive
and
tumor,
continue
to
threaten
human
health
impose
a
significant
financial
burden
despite
advancements
in
clinical
treatment.
Pyroptosis,
pro-inflammatory
programmed
cell
death
pathway,
plays
an
important
role
the
regulation
of
inflammation.
Moderate
pyroptosis
contributes
activation
native
immunity,
whereas
excessive
is
associated
with
occurrence
progression
Pyroptosis
complicated
tightly
controlled
by
various
factors.
Accumulating
evidence
has
confirmed
that
epigenetic
modifications
post-translational
(PTMs)
play
vital
roles
pyroptosis.
Epigenetic
modifications,
which
include
DNA
methylation
histone
(such
as
acetylation),
ubiquitination,
phosphorylation,
acetylation)
precisely
manipulate
gene
expression
protein
functions
at
transcriptional
levels,
respectively.
In
this
review,
we
summarize
major
pathways
focus
on
regulatory
mechanisms
pyroptotic
components.
We
also
illustrate
these
within
pyroptosis-associated
inflammatory
diseases.
addition,
discuss
effects
novel
therapeutic
strategies
targeting
pyroptosis,
provide
prospective
insight
into
for
treatment
Abstract
Posttranslational
modifications
play
a
crucial
role
in
governing
cellular
functions
and
protein
behavior.
Researchers
have
implicated
dysregulated
posttranslational
misfolding,
which
results
cytotoxicity,
particularly
neurodegenerative
diseases
such
as
Alzheimer
disease,
Parkinson
Huntington
disease.
These
aberrant
cause
proteins
to
gather
certain
parts
of
the
brain
that
are
linked
development
diseases.
This
leads
neuronal
dysfunction
start
disease
symptoms.
Cognitive
decline
neurological
impairments
commonly
manifest
patients,
underscoring
urgency
comprehending
modifications’
impact
on
function
for
targeted
therapeutic
interventions.
review
elucidates
critical
link
between
specific
modifications,
focusing
Tau,
APP,
α‐synuclein,
Huntingtin
protein,
Parkin,
DJ‐1,
Drp1.
By
delineating
prominent
within
underscores
significance
understanding
interplay
among
these
modifications.
Emphasizing
10
key
abnormal
this
study
aims
provide
comprehensive
framework
investigating
holistically.
The
insights
presented
herein
shed
light
potential
avenues
aimed
at
modulating
mitigate
aggregation
retard
progression.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 24, 2025
Abstract
The
attachment
of
Post-Translational
Modifications
(PTMs)
to
proteins
plays
key
roles
in
the
regulation
activity
and
stability
various
proteins.
Here
we
utilized
nematode
Caenorhabditis
elegans
test
whether
UFMylation,
a
PTM
that
was
found
be
essential
for
biological
functions,
is
involved
aging
protein
homeostasis
(proteostasis).
Our
results
indicate
lowering
UFMylation
extends
lifespan
mitigates
toxicity
aggregative
underlie
development
neurodegenerative
disorders
humans.
Mass
spectrometric
analysis
unveiled
aging-regulating
proteins,
including
components
nucleolar
FIB-1-NOL-56
complex
germline
resident
CAR-1
CGH-1,
governs
proteostasis
across
tissues.
Functional
analyses
proteostasis-regulating
transcription
factors
DAF-16
SKN-1
are
crucial
counter
proteotoxic
effect
reduced
which
mediated
by
rate
aggregation
enhanced
degradation.
These
insights
highlight
important
PTMs
point
at
research
directions
new
therapies
disorders.
PeerJ,
Год журнала:
2025,
Номер
13, С. e19100 - e19100
Опубликована: Апрель 7, 2025
Forty-eight
million
people
worldwide
suffer
from
dementia,
often
associated
with
the
growth
of
elderly
population.
There
are
also
concerns
about
younger
population,
where
increasing
acute
and
chronic
abuse
alcohol
neurotoxic
substances
may
contribute
to
brain
damage
early
onset
dementia.
Alzheimer’s
disease
(AD)
accounts
for
60%
dementia
cases
most
therapies
used
so
far
have
been
unsuccessful.
Genetic,
epigenetic
vascular
factors
pathogenesis
AD.
Among
mechanisms,
modulation
microRNA
(miRs)
plays
an
important
role.
To
detect
genes
pathways
involved
in
AD,
we
performed
original
bioinformatic
analysis
published
dysregulated
miRs
using
MIcroRNA
ENrichment
TURned
NETwork
(MIENTURNET)
followed
by
Reactome
tools.
The
interrogation
these
platforms
allowed
us
discover
common
putative
(by
MIENTURNET)
targeted
which
set
altered
tool).
Our
silico
showed
that
β-catenin
phosphorylation
cascade
Netrin-1
signalling,
resulted
as
significant.
Lastly,
based
on
assumption
food
bioactive
compounds
(BC)
modulate
miRs,
turn
a
literature
search
demonstrated
some
BC
indeed
able
genes.
Curcumin,
osthole,
puerarin,
xanthoceraside,
sulforaphane,
salvianolic
acid
A,
resveratrol
andrographolide
lead
upregulation
Wnt/β-catenin
pathway.
Choline,
methionine,
folate
vitamin
B6/B12
In
conclusion,
our
identified
their
pathways,
paving
interesting
new
insights
diagnosis
potential
therapeutic
interventions.
Over
400
different
types
of
post‐translational
modifications
(PTMs)
have
been
reported
and
over
200
various
PTMs
discovered
using
mass
spectrometry
(MS)‐based
proteomics.
MS‐based
proteomics
has
proven
to
be
a
powerful
method
capable
global
PTM
mapping
with
the
identification
modified
proteins/peptides,
localization
sites
quantitation.
play
regulatory
roles
in
protein
functions,
activities
interactions
heart
related
diseases,
such
as
ischemia/reperfusion
injury,
cardiomyopathy
failure.
The
recognition
that
are
specific
cardiovascular
pathology
clarification
mechanisms
underlying
these
at
molecular
levels
crucial
for
discovery
novel
biomarkers
application
clinical
setting.
With
sensitive
MS
instrumentation
biostatistical
methods
precise
processing
data,
low‐abundance
can
successfully
detected
beneficial
or
unfavorable
effects
on
cardiac
function
determined.
Moreover,
computational
proteomic
strategies
predict
based
data
gained
an
increasing
interest
contribute
characterization
profiles
disorders.
More
recently,
machine
learning‐
deep
learning‐based
employed
locations
explore
crosstalk.
In
this
review
article,
briefly
overviewed,
approaches
identification/quantitation
discussed
recently
published
studies
associated
diseases
included.
