Journal of Applied Pharmaceutical Science, Год журнала: 2023, Номер unknown
Опубликована: Янв. 1, 2023
Bibliometric analysis and visualization of research on nanotechnology in dentistry from 1999 to 2022Namrata Dagli, Bhavin Patel, Rushabh Nihad Adnan, Rahnuma Ahmad, Mainul Haque, Santosh Kumar
Язык: Английский
Journal of Neuroimmune Pharmacology, Год журнала: 2024, Номер 19(1)
Опубликована: Фев. 29, 2024
Abstract Inflammasomes are important modulators of inflammation. Dysregulation inflammasomes can enhance vulnerability to conditions such as neurodegenerative diseases, autoinflammatory and metabolic disorders. Among various inflammasomes, Nucleotide-binding oligomerization domain leucine-rich repeat pyrin domain-containing protein 3 (NLRP3) is the best-characterized inflammasome related inflammatory diseases. NLRP3 an intracellular sensor that recognizes pathogen-associated molecular patterns damage-associated resulting in assembly activation inflammasome. The includes NLRP3, adaptor apoptosis-associated speck-like (ASC), effector cysteine protease procaspase-1 plays imperative role caspase-1 stimulation which further initiates a secondary response. Regulation ameliorates NLRP3-mediated Much effort has been invested studying activation, exploration specific inhibitors epigenetic mechanisms controlling This review gives overview established assembly, its brief mechanistic activations well current update on non-specific could be used We also focused recently discovered mediated by DNA methylation, histone alterations, microRNAs regulating expression inflammasome, resulted novel method gaining insight into modulate activity introducing potential therapeutic strategies for CNS Graphical "Image missing"
Язык: Английский
Процитировано
29
Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 754, С. 151526 - 151526
Опубликована: Фев. 22, 2025
Язык: Английский
Процитировано
2
Progress in Neurobiology, Год журнала: 2023, Номер 231, С. 102534 - 102534
Опубликована: Сен. 30, 2023
Язык: Английский
Процитировано
16
Ageing Research Reviews, Год журнала: 2023, Номер 92, С. 102098 - 102098
Опубликована: Окт. 30, 2023
Язык: Английский
Процитировано
16
Molecular Neurobiology, Год журнала: 2023, Номер 60(10), С. 5557 - 5577
Опубликована: Июнь 16, 2023
Abstract Neurodegenerative disorders (NDD) have grabbed significant scientific consideration due to their fast increase in prevalence worldwide. The specific pathophysiology of the disease and amazing changes brain that take place as it advances are still top issues contemporary research. Transcription factors play a decisive role integrating various signal transduction pathways ensure homeostasis. Disruptions regulation transcription can result pathologies, including NDD. Numerous microRNAs epigenetic emerged candidates for determining precise etiology Consequently, understanding by what means regulated how deregulation contributes neurological dysfunction is important therapeutic targeting they modulate. RE1-silencing factor (REST) also named neuron-restrictive silencer (NRSF) has been studied REST was realized be part neuroprotective element with ability tuned influenced numerous microRNAs, such 124, 132, 9 implicated This article looks at influence controlling function progression Alzheimer’s (AD), Parkinson’s (PD), Huntington’s (HD) disease. Furthermore, therapeutically exploit possibility we bring forth an overview drug-delivery systems modulate regulating Graphical abstract
Язык: Английский
Процитировано
14
CNS Neuroscience & Therapeutics, Год журнала: 2025, Номер 31(4)
Опубликована: Апрель 1, 2025
ABSTRACT Background Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive impairment and neuroinflammation. Astrocytes play key role in the neuroinflammatory environment of AD, especially through lipid metabolism regulation. However, mechanisms which astrocytes, particularly triggering receptor expressed on myeloid cells 2 (Trem2) receptor, contribute to dysregulation neuroinflammation AD remain inadequately understood. Methods We employed an mouse model integrated single‐cell RNA sequencing (scRNA‐seq), transcriptomics, high‐throughput metabolomics analyze inflammatory profiles astrocytes. Differential gene expression was further validated with GEO database, vitro vivo experiments were conducted assess impact Trem2 modulation astrocytic inflammation composition. Results Our findings demonstrate that modulates affecting fatty acid phospholipid pathways. In model, suppressed, enhancing nuclear factor‐κB (NF‐κB) signaling promoting secretion pro‐inflammatory factors such as tumor necrosis factor‐α (TNF‐α) interleukin‐6 (IL‐6). overexpression reduced altered composition, attenuating both vivo. These results underscore Trem2's regulatory its significant AD. Conclusions This study identifies pivotal regulator providing potential molecular targets for early intervention therapeutic strategies aimed at mitigating progression.
Язык: Английский
Процитировано
0
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 89, С. 105067 - 105067
Опубликована: Окт. 16, 2023
Язык: Английский
Процитировано
11
Non-Coding RNA, Год журнала: 2025, Номер 11(1), С. 2 - 2
Опубликована: Янв. 9, 2025
Aging leads to cognitive decline and increased risk of neurodegenerative diseases. While molecular changes in central nervous system (CNS) cells contribute this decline, the mechanisms are not fully understood. Long non-coding RNAs (lncRNAs) key regulators cellular functions. Background/Objectives: The roles lncRNAs aging, especially glial cells, well characterized. Methods: We investigated lncRNA expression non-neuronal from aged mice identified 3222401L13Rik, a previously unstudied lncRNA, as upregulated astrocytes during aging. Results: Knockdown 3222401L13Rik primary revealed its critical role regulating genes for neuronal support synapse organization, function conserved human iPSC-derived astrocytes. A interacts with transcription factor Neuronal PAS Domain Protein 3 (Npas3), overexpression Npas3 rescues deficits lacking 3222401L13Rik. Conclusions: These data suggest that upregulation may help delay age-related decline.
Язык: Английский
Процитировано
0
Pharmaceutics, Год журнала: 2025, Номер 17(1), С. 128 - 128
Опубликована: Янв. 17, 2025
Alzheimer's disease (AD) represents an escalating global health crisis, constituting the leading cause of dementia among elderly and profoundly impairing their quality life. Current FDA-approved drugs, such as rivastigmine, donepezil, galantamine, memantine, offer only modest symptomatic relief are frequently associated with significant adverse effects. Faced this challenge in line advances understanding pathophysiology neurodegenerative condition, various innovative therapeutic strategies have been explored. Here, we review novel approaches inspired by advanced knowledge underlying pathophysiological mechanisms disease. Among alternatives, immunotherapy stands out, employing monoclonal antibodies to specifically target eliminate toxic proteins implicated AD. Additionally, use medicinal plants is examined, synergistic effects components may confer neuroprotective properties. The modulation gut microbiota also addressed a peripheral strategy that could influence neuroinflammatory degenerative processes brain. Furthermore, potential emerging approaches, microRNAs regulate key cellular nanotherapy, which enables precise drug delivery central nervous system, analyzed. Despite promising these strategies, incidence continues rise. Therefore, it proposed achieving effective treatment future require integration combined maximizing different interventions.
Язык: Английский
Процитировано
0
Neurochemical Research, Год журнала: 2025, Номер 50(1)
Опубликована: Янв. 20, 2025
Язык: Английский
Процитировано
0