Experimental Cell Research, Год журнала: 2024, Номер unknown, С. 114393 - 114393
Опубликована: Дек. 1, 2024
Язык: Английский
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1381 - 1381
Опубликована: Янв. 23, 2024
Hepatocellular carcinoma (HCC) remains a global health challenge with limited treatment options and poor prognosis for advanced-stage patients. Recent advancements in cancer immunotherapy have generated significant interest exploring novel approaches to combat HCC. One such approach involves the unique versatile subset of T cells known as γδ cells. represent distinct lymphocytes that differ from conventional αβ terms antigen recognition effector functions. They play crucial role immunosurveillance against various malignancies, including studies demonstrated can directly recognize target HCC cells, making them an attractive candidate immunotherapy. In this article, we aimed explore exerted by context We investigate strategies designed maximize therapeutic effectiveness these examine challenges opportunities inherent applying research findings clinical practice. The potential bring about revolutionary shift capitalizing on attributes offers considerable promise enhancing patient outcomes, warranting further investigation.
Язык: Английский
Процитировано
7
Metabolites, Год журнала: 2024, Номер 14(6), С. 325 - 325
Опубликована: Июнь 8, 2024
Epigenetic and metabolic reprogramming alterations are two important features of tumors, their reversible, spatial, temporal regulation is a distinctive hallmark carcinogenesis. Epigenetics, which focuses on gene regulatory mechanisms beyond the DNA sequence, new entry point for tumor therapy. Moreover, drives hepatocellular carcinoma (HCC) initiation progression, highlighting significance metabolism in this disease. Exploring inter-regulatory relationship between epigenetic modification has become one hot directions current research. As viral etiologies have given way to dysfunction-associated steatotic liver disease (MASLD)-induced HCC, it urgent that complex molecular pathways linking them hepatocarcinogenesis be explored. However, how aberrant crosstalk modifications affects MASLD-induced HCC lacks comprehensive understanding. A better understanding linkages necessary improve treatment strategies. For reason, review examines interwoven landscape carcinogenesis context focusing regulating development interactions while also updating advances modification-based therapeutic drugs HCC.
Язык: Английский
Процитировано
4
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 4, 2025
CXCL14 is a highly conserved chemokine expressed in various cell types, playing crucial roles both physiological and pathological processes, including immune regulation tumorigenesis. Recently, the role of tumors has attracted considerable attention. However, previous pan-cancer studies have reported inconsistencies regarding effects on tumors, particularly concerning its expression levels tumor tissues influence phenotypes cancer cells. This variability believed to stem from context-dependent nature CXCL14, as different sources secretion within distinct microenvironments may mediate diverse biological effects. Such phenomena also been observed prostate research. Despite foundational understanding cancer, there remains lack comprehensive reviews summarizing specific this systematically analyzing reasons behind complex Therefore, article aims discuss microenvironment explore future research directions potential applications.
Язык: Английский
Процитировано
0
Cancers, Год журнала: 2025, Номер 17(6), С. 940 - 940
Опубликована: Март 10, 2025
Exosomes have emerged as pivotal players in precision oncology, offering innovative solutions to longstanding challenges such metastasis, therapeutic resistance, and immune evasion. These nanoscale extracellular vesicles facilitate intercellular communication by transferring bioactive molecules that mirror the biological state of their parent cells, positioning them transformative tools for cancer diagnostics therapeutics. Recent advancements exosome engineering, artificial intelligence (AI)-driven analytics, isolation technologies are breaking barriers scalability, reproducibility, clinical application. Bioengineered exosomes being leveraged CRISPR-Cas9 delivery, while AI models enhancing biomarker discovery liquid biopsy accuracy. Despite these advancements, key obstacles heterogeneity populations lack standardized protocols persist. This review synthesizes pioneering research on biology, molecular translation, emphasizing dual roles both mediators tumor progression intervention. It also explores emerging areas, including microbiome–exosome interactions integration machine learning exosome-based medicine. By bridging innovation with translational strategies, this work charts a forward-looking path integrating into next-generation care, setting it apart comprehensive guide overcoming technological hurdles rapidly evolving field.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Март 12, 2025
NAD(P)H dehydrogenase quinone 1 (NQO1) is overexpressed in various cancers and strongly associated with an immunosuppressive microenvironment poor prognosis. In this study, we explored the role of NQO1 microenvironment, prognosis immunotherapy Hepatocellular carcinoma (HCC) using multi-omics analysis machine learning. The results revealed that was significantly HCC cells. NQO1+HCC cells were correlated facilitated tumor-associated macrophages (TAMs) polarization to M2 macrophages. We identified core NQO1-related genes (NRGs) developed NRGs-related risk-scores hepatocellular (NRSHC). comprehensive nomogram integrating NRSHC, age, pathological tumor-node-metastasis (pTNM) Stage achieved area under curve (AUC) above 0.7, demonstrating its accuracy predicting survival outcomes responses patients. High-risk patients exhibited worse prognoses but greater sensitivity immunotherapy. Additionally, a web-based prediction tool designed enhance clinical utility. conclusion, may play critical accelerates progression. NRSHC model accompanying tools offer valuable insights for personalized treatment.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14704 - 14704
Опубликована: Сен. 28, 2023
The escalating global prevalence of obesity and its intricate association with the development hepatocellular carcinoma (HCC) pose a substantial challenge to public health. Obesity, acknowledged as pervasive epidemic, is linked an array chronic diseases, including HCC, catalyzing need for comprehensive understanding molecular underpinnings. Notably, HCC has emerged leading malignancy rising incidence mortality. transition from viral etiologies prominence metabolic dysfunction-associated fatty liver disease (MAFLD)-related underscores urgent explore pathways linking hepatic carcinogenesis. This review delves into interwoven landscape carcinogenesis in context obesity-driven while also navigating using current therapeutic strategies future prospects combating obesity-related HCC. We underscore pivotal role risk factor propose integrated approach encompassing lifestyle interventions, pharmacotherapy, exploration emerging targeted therapies. As obesity-HCC nexus continues healthcare systems globally, mechanisms innovative imperative alleviate burden this dual menace.
Язык: Английский
Процитировано
9
Cancers, Год журнала: 2024, Номер 16(14), С. 2609 - 2609
Опубликована: Июль 22, 2024
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and presents a continuously growing incidence high mortality rates worldwide. Besides advances in diagnosis promising results of pre-clinical studies, established curative therapeutic options for HCC are not currently available. Recent progress understanding tumor microenvironment (TME) interactions has turned scientific interest to immunotherapy, revolutionizing treatment patients with advanced HCC. However, limited number who benefit from current immunotherapeutic creates need explore novel targets associated improved patient response potentially establish them as part combinatorial options. Glucocorticoid-induced TNFR-related protein (GITR) belongs TNFR superfamily (TNFRSF) promotes CD8+ CD4+ effector T-cell function simultaneous inhibition Tregs function, when activated by its ligand, GITRL. GITR considered potential immunotherapy target various kinds neoplasms, especially concomitant use programmed cell-death protein-1 (PD-1) blockade. Regarding disease, expression progenitor cells been observed, impaired hepatocyte differentiation, decreased cell-mediated regeneration. Considering real-world data proving anti-tumor effect recently published evidence models involvement pre-cancerous idea inclusion theoretically arises. In this review, we aim summarize supporting targeting GITR/GITRL signaling strategy
Язык: Английский
Процитировано
2
Pharmaceutics, Год журнала: 2023, Номер 15(10), С. 2460 - 2460
Опубликована: Окт. 13, 2023
Hepatocellular carcinoma (HCC) stands as a significant contributor to global cancer-related mortality. Chronic inflammation, often arising from diverse sources such viral hepatitis, alcohol misuse, nonalcoholic fatty liver disease (NAFLD), and steatohepatitis (NASH), profoundly influences HCC development. Within this context, the interplay of extracellular vesicles (EVs) gains prominence. EVs, encompassing exosomes microvesicles, mediate cell-to-cell communication cargo transfer, impacting various biological processes, including inflammation cancer progression. Toll-like receptor 4 (TLR4), key sentinel innate immune system, recognizes both pathogen-associated molecular patterns (PAMPs) damage-associated (DAMPs), thereby triggering signaling cascades pro-inflammatory cytokine release. The intricate involvement TLR4 pathway in chronic pathogenesis is discussed study. Moreover, we delve into therapeutic potential modulating using EVs novel agents for HCC. This review underscores multifaceted role context proposes innovative avenues targeted interventions against formidable disease.
Язык: Английский
Процитировано
6
Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Июнь 26, 2024
Exosomes are extracelluar vesicles that facilitate intercellular communication and pivotal in post-transcriptional regulation within cellular gene regulatory networks, impacting pathogen dynamics. These serve as crucial regulators of immune responses, mediating interactions enabling the introduction viral pathogenic regions into host cells. released from virus-infected cells harbor diverse microRNAs (miRNAs), which can be transferred to recipient cells, thereby modulating virus infection. This transfer is a critical element molecular interplay mediated by exosomes. Additionally, endosomal sorting complex required for transport (ESCRT) exosomes plays vital role infection, with ESCRT components binding proteins budding. review elucidates roles their constituents invasion viruses, aiming shed new light on transmission via
Язык: Английский
Процитировано
0
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Июль 11, 2024
Background This study aims to screen inflammation-related genes closely associated with the prognosis of hepatocellular carcinoma (HCC) accurately forecast HCC patients. Methods Gene expression matrices and clinical information for liver cancer samples were obtained from Cancer Genome Atlas (TCGA) International Consortium (ICGC). An intersection differentially expressed normal GeneCards yielded HCC. Cox regression minor absolute shrinkage selection operator (LASSO) analysis filter prognosis. The prognostic value model was confirmed by drawing Kaplan–Meier ROC curves. Select between high-risk low-risk groups perform GO KEGG pathways analyses. CIBERSORT conducted assess associations risk models immune cells verified using real-time qPCR. Results A total six hub (C3, CTNNB1, CYBC1, DNASE1L3, IRAK1, SERPINE1) selected multivariate construct a model. validation evaluation showed that it has an excellent ability predict line plot drawn indicate patients’ survival, calibration curve revealed satisfactory predictability. Among genes, C3 DNASE1L3 are relatively low in HCCLM3 97H cell lines, while SERPINE1 overexpressed lines. Conclusion One new inflammatory factor-associated constructed this study. score can be independent predictor judging survival.
Язык: Английский
Процитировано
0