Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4300 - 4300
Опубликована: Апрель 12, 2024
Sarcopenia
is
a
prevalent
degenerative
skeletal
muscle
condition
in
the
elderly
population,
posing
tremendous
burden
on
diseased
individuals
and
healthcare
systems
worldwide.
Conventionally,
sarcopenia
currently
managed
through
nutritional
interventions,
physical
therapy,
lifestyle
modification,
with
no
pharmaceutical
agents
being
approved
for
specific
use
this
disease.
As
pathogenesis
of
still
poorly
understood
there
treatment
recognized
as
universally
effective,
recent
research
efforts
have
been
directed
at
better
comprehending
illness
diversifying
strategies.
In
respect,
paper
overviews
new
advances
correlation
its
underlying
mechanisms.
Specifically,
review
creates
an
updated
framework
sarcopenia,
describing
etiology,
pathogenesis,
risk
factors,
conventional
treatments,
further
discussing
emerging
therapeutic
approaches
like
drug
formulations,
delivery
systems,
stem
cell
therapies,
tissue-engineered
scaffolds
more
detail.
Язык: Английский
Advances in sarcopenia: mechanisms, therapeutic targets, and intervention strategies
Archives of Pharmacal Research,
Год журнала:
2024,
Номер
47(4), С. 301 - 324
Опубликована: Апрель 1, 2024
Язык: Английский
Near Infrared‐Mediated Intracellular NADH Delivery Strengthens Mitochondrial Function and Stability in Muscle Dysfunction Model
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 31, 2025
Abstract
Mitochondrial
transfer
emerges
as
a
promising
therapy
for
the
restoration
of
mitochondrial
function
in
damaged
cells,
mainly
due
to
its
limited
immunogenicity.
However,
isolated
mitochondria
rapidly
lose
because
they
produce
little
energy
outside
cells.
Therefore,
this
study
investigates
whether
near
infrared
(NIR)‐mediated
nicotinamide
adenine
dinucleotide
(NADH)
pre‐treatment
enhances
and
stability
mitochondria‐donor
cells
prior
transplantation.
Clinical
applications
NADH,
an
essential
electron
donor
oxidative
phosphorylation
process,
are
restricted
cellular
uptake
NADH.
To
address
this,
photo‐mediated
method
optimizes
direct
NADH
delivery
into
increases
absorption.
L6
treated
with
irradiated
NIR
enhanced
uptake,
significantly
improving
production
function.
Importantly,
improved
functional
characteristics
maintained
even
after
isolation
from
Primed
mitochondria,
i.e.,
those
by
NIR‐mediated
(P‐MT),
encapsulated
fusogenic
liposomes
delivered
muscle
dysfunction.
Compared
conventional
P‐MT
promote
greater
recovery
regeneration.
These
findings
suggest
that
is
effective
strategy
function,
has
potential
lead
novel
treatments
disorders
degeneration.
Язык: Английский
Navigating Sarcopenia Risks in GLP-1RA Therapy for Advanced Heart Failure
Biomedicines,
Год журнала:
2025,
Номер
13(5), С. 1108 - 1108
Опубликована: Май 2, 2025
Cardiac
cachexia
(CC)
is
a
severe
complication
of
advanced
heart
failure
(HF),
characterized
by
involuntary
weight
loss
and
muscle
wasting,
leading
to
poor
outcomes
higher
mortality.
Despite
its
severity,
CC
remains
under-recognized
undertreated,
lacking
targeted
therapies
specifically
addressing
pathophysiology.
Glucagon-like
peptide-1
receptor
agonists
(GLP-1RAs),
though
beneficial
in
reducing
cardiovascular
risk
patients
with
HF,
may
exacerbate
wasting
cachectic
patients,
necessitating
further
investigation.
Non-pharmacological
strategies,
including
tailored
nutritional
support
exercise
programs,
have
shown
positive
effects
on
body
composition
quality
life
CC.
However,
there
gap
recommendations
preventive
strategies
pharmacologic
for
concomitant
GLP-1RA
use.
This
review
highlights
the
multifactorial
mechanisms
underlying
current
emerging
therapeutic
approaches
mitigating
HF-related
sarcopenia
while
GLP-1RAs.
Язык: Английский