Neurocellular Stress Response to Mojave Type A Rattlesnake Venom: Study of Molecular Mechanisms Using Human iPSC-Derived Neural Stem Cell Model DOI Creative Commons
Satish Kumar, Miriam Aceves, José A. Tapia Granados

и другие.

Biomolecules, Год журнала: 2025, Номер 15(3), С. 381 - 381

Опубликована: Март 6, 2025

The Mojave rattlesnake venom shows significant geographical variability. of Type A animals primarily contains β-neurotoxin referred to as Toxin (MTX), which makes bites from this snake particularly feared. We performed a genome-wide transcriptomic analysis the neurocellular response using induced pluripotent stem cell-derived neural cells unveil molecular mechanisms underlying damage caused by snake’s envenomation. Our results suggest that metalloproteases, although having limited repertoire in venom, facilitate spread digesting tissue’s extracellular matrix. MTX, is composed heterodimers basic and acidic phospholipase-A2, co-opts host arachidonic acid Ca2+ second messenger triggers multiple signaling cascades, such activation MAPKs NF-κB-regulated proinflammatory genes; neurotransmitter overload excitatory synapses leading presynaptic blockade nerve signals; upregulation unfolded protein (UPR) due depletion endoplasmic reticulum. upregulated UPR oxidative stress reactive oxygen species generated cytochromeP4501A1-mediated hydroxylation contribute mitochondrial toxicity. UPR, toxicity, synergistically contributed apoptotic ferroptotic cell death.

Язык: Английский

Unraveling the role of the nucleocapsid protein in SARS-CoV-2 pathogenesis: From viral life cycle to vaccine development DOI
Yousra A. El‐Maradny,

Moustafa A. Badawy,

Kareem I. Mohamed

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 279, С. 135201 - 135201

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

5
Characterizing the diabetes-induced pathological changes of the mouse lung by single-cell RNA sequencing DOI

Ying‐Ming Tsai,

Yi Hsuan Lee,

Chao‐Yuan Chang

и другие.

Life Sciences, Год журнала: 2025, Номер unknown, С. 123408 - 123408

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Neurocellular Stress Response to Mojave Type A Rattlesnake Venom: Study of Molecular Mechanisms Using Human iPSC-Derived Neural Stem Cell Model DOI Creative Commons
Satish Kumar, Miriam Aceves, José A. Tapia Granados

и другие.

Biomolecules, Год журнала: 2025, Номер 15(3), С. 381 - 381

Опубликована: Март 6, 2025

The Mojave rattlesnake venom shows significant geographical variability. of Type A animals primarily contains β-neurotoxin referred to as Toxin (MTX), which makes bites from this snake particularly feared. We performed a genome-wide transcriptomic analysis the neurocellular response using induced pluripotent stem cell-derived neural cells unveil molecular mechanisms underlying damage caused by snake’s envenomation. Our results suggest that metalloproteases, although having limited repertoire in venom, facilitate spread digesting tissue’s extracellular matrix. MTX, is composed heterodimers basic and acidic phospholipase-A2, co-opts host arachidonic acid Ca2+ second messenger triggers multiple signaling cascades, such activation MAPKs NF-κB-regulated proinflammatory genes; neurotransmitter overload excitatory synapses leading presynaptic blockade nerve signals; upregulation unfolded protein (UPR) due depletion endoplasmic reticulum. upregulated UPR oxidative stress reactive oxygen species generated cytochromeP4501A1-mediated hydroxylation contribute mitochondrial toxicity. UPR, toxicity, synergistically contributed apoptotic ferroptotic cell death.

Язык: Английский

Процитировано

0