TrAC Trends in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 118137 - 118137
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0Association between hydrocarbon exposure and risk of stroke: a systematic literature review
BMC Neurology, Год журнала: 2025, Номер 25(1)
Опубликована: Фев. 21, 2025
Abstract Background Hydrocarbon exposure, including polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs), is increasingly linked to vascular dysfunction stroke, a leading cause of morbidity mortality globally. Common in occupational environmental contexts, induce oxidative stress, systemic inflammation, endothelial dysfunction, disrupting health. This systematic review examines the association between hydrocarbon exposure emphasizing specific metabolites their cerebrovascular effects. Methods A comprehensive search across PubMed, Embase, Web Science was conducted through December 10 2024, identifying observational studies exploring stroke risk. Studies meeting predefined inclusion criteria, excluding those with major methodological flaws, were synthesized narratively. Variations types, population demographics, outcomes considered. Results Six studies, five cross-sectional one retrospective cohort, sample sizes ranging from 5,537 283,666 participants, demonstrated significant associations Key findings revealed strong for like 1-hydroxynaphthalene (OR: 1.89; 95% CI: 1.62–2.20) 2-hydroxyfluorene 1.94; 1.66–2.26). However, variability noted, attributed differences study design, levels, populations studied. Conclusion highlights complex relationship risk, some indicating others reporting inconsistencies. Standardized, large-scale research essential clarify this relationship, identify high-risk populations, guide public health strategies mitigate prevent stroke. Clinical trial number Not applicable.
Язык: Английский
Процитировано
0Age-Related Differences in Lipopolysaccharide-Induced Delirium-like Behavior Implicate the Distinct Microglial Composition in the Hippocampus
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2055 - 2055
Опубликована: Фев. 26, 2025
As the global population ages, mechanisms underlying age-related susceptibility to delirium have attracted attention. Given central role of microglia in pathogenesis inflammation-related delirium, we investigated temporal dynamics neurobehavioral changes and microglial responses, following lipopolysaccharide (LPS, 200 μg/kg) administration young old male C57BL/6 mice. Although a similar illness trajectory across 48 h post-treatment (HPT) was observed both age groups, old-LPS mice exhibited worsened delirium-like behavior. At HPT, but not mice, significantly decreased hippocampal neuronal activity coincided with overactivation. Widespread activation present at 3 HPT subsided by 12 indicating generally retarded prolonged response LPS challenge However, for p16INK4a-negative (with low abundance aged brain) comparable morphological activation, which p16INK4a-positive (highly abundant brain). These results suggest that LPS-induced behavior accompanied different patterns might implicate composition shifts optimizing represents promising approach reduce vulnerability inflammatory challenge.
Язык: Английский
Процитировано
0Therapeutic potential and limitation of condensed and hydrolyzed tannins in Parkinson's disease
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141814 - 141814
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0The Morbid Impact of Environmental Toxins on the Human Nervous System: Peripheral Neuropathy Nexus with Organic Solvents, Pesticides, and Heavy Metals
European journal of ecology, biology and agriculture., Год журнала: 2024, Номер 1(3), С. 53 - 74
Опубликована: Июль 1, 2024
Peripheral neuropathy is a complex disorder characterized by damage to the peripheral nerves, resulting in various sensory, motor, and autonomic symptoms. This review offers detailed examination of neuropathy, covering its prevalence, effects on individuals society, causes, diagnosis, mechanisms, treatment, management, focusing association with environmental toxins. The etiology multifactorial, encompassing diverse causes such as diabetes mellitus, autoimmune diseases, infections, vitamin deficiencies, toxic exposures, genetic factors. Notably, toxins, including organic solvents, pesticides, heavy metals, have been implicated pathogenesis neuropathy. Environmental toxins exert their neurotoxic through disruption neuronal membrane integrity, interference neurotransmission, induction oxidative stress, promotion inflammatory responses. Accurate diagnosis involves comprehensive medical history, neurological examination, electrophysiological studies, imaging tests, laboratory investigations identify underlying toxin exposure. Treatment strategies for toxin-induced focus eliminating exposure, managing symptoms, preventing further nerve damage. Pharmacological interventions, adjunctive therapies, nutritional support, regular monitoring, patient education are integral management. A multidisciplinary approach fundamental diagnosing effectively, emphasizing identifying mitigating exposure alleviate symptoms improve quality life.
Язык: Английский
Процитировано
3Distinct baseline toxicity of volatile organic compounds (VOCs) in gaseous and liquid phases: mixture effects and potential molecular mechanisms
Journal of Hazardous Materials, Год журнала: 2024, Номер 485, С. 136890 - 136890
Опубликована: Дек. 14, 2024
Язык: Английский
Процитировано
3The Dangers of Consuming Local Wine or Beer
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
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