Nutrients, Год журнала: 2024, Номер 16(24), С. 4405 - 4405

Опубликована: Дек. 22, 2024

The gut–brain axis plays an integral role in maintaining overall health, with growing evidence suggesting its impact on the development of various neuropsychiatric disorders, including depression. This review explores complex relationship between gut microbiota and glutamate (Glu) regulation, highlighting effect brain particularly context depression following certain neurological insults. We discuss how microbial populations can either facilitate or limit Glu uptake, influencing bioavailability predisposing to neuroinflammation neurotoxicity. Additionally, we examine metabolites their influence blood–brain barrier neurotransmitter systems involved mood regulation. therapeutic potential microbiome-targeted interventions, such as fecal transplantation, is also highlighted. While much research has explored major depressive disorders other diseases, contribution post-neurological remains underexplored. Future should focus explaining mechanisms linking outcomes, conditions post-stroke depression, post-traumatic brain-injury epilepsy-associated Systematic reviews human clinical studies are needed establish causal relationships assess efficacy therapies improving sequalae after

Язык: Английский