Theoretical perspectives and clinical applications of non-coding RNA in lung cancer metastasis: a systematic review

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 12, 2025

Lung cancer is one of the deadliest malignancies worldwide, with distant metastasis being a major cause death. However, specific mechanisms lung remain unclear. NcRNAs, widely present type non-coding RNAs in body, constitute about 98% human genome, lacking protein-coding capacity but involved various cellular processes such as proliferation, apoptosis, invasion, and migration. Studies have shown that ncRNAs play crucial role cancer, although research this area limited. This review summarizes biological origins functions ncRNAs, their roles metastasis, discusses potential for early screening therapeutic applications cancer. Furthermore, it outlines challenges translating basic advancements into clinical practice.

Язык: Английский

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Plasma Exosomal circRNAs as Potential Biomarkers for Patients with Septic Shock‐Induced Acute Kidney Injury

Biotechnology and Applied Biochemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 24, 2025

ABSTRACT Sepsis‐induced acute kidney injury (AKI) is marked by high mortality and poor prognosis. Recent studies suggest that exosomal circRNAs regulate key pathways involved in inflammation, oxidative stress, apoptosis, processes central to sepsis‐induced AKI. This study investigates the differential expression of their functional implications pathogenesis Patients with AKI healthy volunteers were recruited for research. Whole blood samples collected, exosomes isolated characterized through particle detection, transmission electron microscopy, Western blot marker proteins. Real‐time PCR was used analyze , including circ‐Fryl circ‐TLK1 circ‐PTK2 circ‐Ttc3 circ‐VMA21 circ_0091702 . Additionally, assays performed assess cell proliferation, uptake HK‐2 cells exposed from both control samples. Seven patients six individuals enrolled. Exosomal protein markers analyzed plasma groups. Exosomes group (mean diameter: 146.1 nm) 150.9 exhibited a characteristic spherical morphology. Plasma levels ( p < 0.05), 0.01), 0.01) notably lower relative group. showed upregulation downregulation Following exposure exosomes, viability decreased while apoptosis increased. such as hold potential candidate biomarkers therapeutic targets

Язык: Английский

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Functional tumor-derived exosomes in NSCLC progression and clinical implications

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Март 19, 2025

Non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases and remains one the leading causes cancer-related mortality worldwide. The high rate is primarily driven by delayed diagnosis, rapid metastasis, frequent recurrence. Tumor-derived exosomes (TEXs) have emerged as critical mediators in NSCLC progression, offering valuable insights into tumor microenvironment. Exosomes are small membrane vesicles that facilitate intercellular communication transport bioactive molecules, including proteins, RNAs, DNAs, thereby reflecting genetic complexity tumors. These play a key role promoting epithelial-mesenchymal transition (EMT), neovascularization, drug resistance, immune evasion, which pivotal development NSCLC. This review explores diverse roles TEXs focusing on their involvement pre-metastatic niche formation, tissue modulation. Specifically, we discuss exosome-associated RNAs proteins NSCLC, contribute to growth metastasis. Furthermore, explore potential biomarkers emphasizing application prognosis, prediction resistance targeted therapies immunotherapies.

Язык: Английский

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The Regulatory Role of NcRNAs in Pyroptosis and Disease Pathogenesis

Cell Biochemistry and Biophysics, Год журнала: 2025, Номер unknown

Опубликована: Апрель 18, 2025

Язык: Английский

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