Construction of regulatory T cells specific genes predictive models of prostate cancer patients based on machine learning: a computational analysis and in vitro experiments DOI Creative Commons
Zhengrong Zhou, Chang Yin Liang

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 13, 2025

Diseases are often caused by multiple factors, regulatory T cells specific genes (RTSGs) have been shown to be associated with cancer, however, their role in prostate cancer (PRAD) has not fully explored. RTSGs PRAD prognosis were identified using Cox regression analysis and LASSO analysis. Furthermore, a prognostic model was constructed based on the 4 RTSGs, its biological function analyzed. We evaluated differences tumor immune microenvironment signature. Finally, cell experiments confirmed of synaptonemal complex protein-2 (SYCP2) cells. The value patients comprehensively analyzed for first time four values. A risk validated an independent external dataset. In patients, this feature is factor significantly correlated clinical information patients. This also related PRAD. Cell that SYCP2 regulates apoptosis cycle progression significantly. Therefore, may become important participating intracellular functional regulation. research provides fundamental theoretical basis improving diagnosis treatment practice.

Язык: Английский

Construction of regulatory T cells specific genes predictive models of prostate cancer patients based on machine learning: a computational analysis and in vitro experiments DOI Creative Commons
Zhengrong Zhou, Chang Yin Liang

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Фев. 13, 2025

Diseases are often caused by multiple factors, regulatory T cells specific genes (RTSGs) have been shown to be associated with cancer, however, their role in prostate cancer (PRAD) has not fully explored. RTSGs PRAD prognosis were identified using Cox regression analysis and LASSO analysis. Furthermore, a prognostic model was constructed based on the 4 RTSGs, its biological function analyzed. We evaluated differences tumor immune microenvironment signature. Finally, cell experiments confirmed of synaptonemal complex protein-2 (SYCP2) cells. The value patients comprehensively analyzed for first time four values. A risk validated an independent external dataset. In patients, this feature is factor significantly correlated clinical information patients. This also related PRAD. Cell that SYCP2 regulates apoptosis cycle progression significantly. Therefore, may become important participating intracellular functional regulation. research provides fundamental theoretical basis improving diagnosis treatment practice.

Язык: Английский

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