Brain Glycogen—Its Metabolic Role in Neuronal Health and Neurological Disorders—An Extensive Narrative Review
Metabolites,
Год журнала:
2025,
Номер
15(2), С. 128 - 128
Опубликована: Фев. 13, 2025
Background:
Brain
glycogen
is
imperative
for
neuronal
health,
as
it
supports
energy
demands
and
metabolic
processes.
This
review
examines
the
pathways
involved
in
storage
utilization
central
nervous
system,
emphasizing
their
role
both
physiology
pathology.
It
explores
how
alterations
metabolism
contribute
to
neurological
disorders,
including
neurodegenerative
diseases,
epilepsy,
conditions
while
highlighting
bidirectional
interaction
between
neurons
glia
maintaining
brain
homeostasis.
Methods:
A
comprehensive
search
of
articles
published
2015
2025
was
conducted
using
following
databases:
ScienceDirect,
Scopus,
Wiley,
Web
Science,
Medline,
PubMed.
The
selection
relevant
studies
based
on
focus
its
conditions,
with
that
did
not
meet
inclusion
criteria
being
excluded.
Results:
processes
are
subject
rigorous
regulation
by
astrocyte-neuron
interactions,
thereby
ensuring
homeostasis
availability.
dysregulation
mobilization
has
been
implicated
development
synaptic
dysfunction,
excitotoxicity,
neurodegeneration
a
variety
disorders.
For
instance,
aberrant
accumulation
diseases
such
Lafora
disease
associated
severe
neurodegeneration,
impaired
shown
exacerbate
deficits
Alzheimer's
epilepsy.
Conclusions:
Targeting
represents
promising
approach
therapeutic
intervention
However,
translation
these
strategies
human
models
remains
challenging,
particularly
regard
long-term
safety
specificity
glycogen-targeted
therapies.
Язык: Английский
Unraveling the cGAS-STING pathway in Alzheimer’s disease: A new Frontier in neuroinflammation and therapeutic strategies
Neuroscience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Neuroinflammation and energy metabolism: a dual perspective on ischemic stroke
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 10, 2025
Ischemic
stroke
is
a
prevalent
form
of
cerebrovascular
accident,
with
its
pathogenesis
involving
the
intricate
interplay
between
neuroinflammation
and
energy
metabolism.
Cerebral
ischemia
disrupts
oxygen
supply,
triggering
metabolic
dysregulation
activating
neuroinflammatory
responses,
ultimately
resulting
in
cellular
damage.
This
review
provides
an
exhaustive
analysis
complex
mechanisms
ischemic
stroke,
particular
focus
on
interaction
The
interruption
supply
due
to
cerebral
initiates
activates
including
release
inflammatory
cytokines
activation
immune
cells,
contributing
damage
further
disturbances.
Studies
indicate
that
metabolism
significantly
impairs
neural
cell
function
interacts
neuroinflammation,
exacerbating
brain
injury.
Therapeutic
strategies
primarily
concentrate
modulating
suppressing
emphasizing
importance
in-depth
research
into
their
provide
theoretical
foundation
for
new
treatment
stroke.
Future
should
how
balance
anti-inflammatory
regulation
minimize
promote
recovery.
Язык: Английский
A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 16, 2024
Abstract
The
high
energetic
demands
of
the
brain
arise
primarily
from
neuronal
activity.
Neurons
consume
substantial
energy
to
transmit
information
as
electrical
signals
and
maintain
their
resting
membrane
potential.
These
requirements
are
met
by
neuro-glial-vascular
(NGV)
ensemble,
which
generates
in
a
coupled
metabolic
process.
In
ageing,
function
becomes
impaired,
producing
less
and,
consequently,
system
is
unable
sustain
needs.
We
propose
multiscale
model
electro-metabolic
coupling
reconstructed
rat
neocortex.
This
combines
an
electro-morphologically
electrophysiological
with
detailed
NGV
model.
Our
results
demonstrate
that
large-scale
effectively
captures
processes
at
circuit
level,
highlighting
importance
heterogeneity
within
circuit,
where
vary
according
characteristics.
Finally,
our
indicates
middle
cortical
layers
particularly
vulnerable
impairment.
Язык: Английский