Pharmacogenetics and Pharmacogenomics, Год журнала: 2025, Номер 2, С. 29 - 36
Опубликована: Март 4, 2025
Introduction. CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) has been recognized as a revolutionary advancement in the biomedical field, offering unparalleled precision and versatility genome editing. This review examines transformative potential of diagnostic therapeutic tool for various diseases. Methods. A systematic was conducted following PRISMA (Preferred Reporting Items Systematic Reviews Meta-Analyses) guidelines. comprehensive search PubMed, Scopus, Google Scholar, Web Science performed to identify relevant Studies published between January 2015 2025. The inclusion criteria focused on peer-reviewed articles discussing CRISPR-based diagnostics, applications, technological advancements. were screened, assessed quality using CASP framework, categorized into thematic areas analysis. Results. platforms, such SHERLOCK DETECTR, analyzed their sensitivity rapidity detecting pathogens, cancer biomarkers, genetic mutations. Emerging innovations, including prime base editing, have explored role expanding capabilities CRISPR. Additionally, advancements delivery mechanisms use alternative Cas proteins discussed impact clinical applicability. Conclusions. Ethical, regulatory, accessibility challenges associated with technology are highlighted, emphasizing importance responsible development equitable deployment. connects cutting-edge translational underscores significant shaping future medicine global health.
Язык: Английский