The Emerging Role of Water Loss in Dog Aging DOI Creative Commons
Gabriella Guelfi, Camilla Capaccia,

Vicente Francisco Ratto

и другие.

Cells, Год журнала: 2025, Номер 14(7), С. 545 - 545

Опубликована: Апрель 4, 2025

Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores emerging role loss as a central underestimated driver functional decline in aging, with focus on dog, both clinically relevant target species model human aging. Age-related alterations metabolism—driven by changes body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced thirst perception, impaired urine concentration—lead to intracellular extracellular dehydration, exacerbating decline. We examine molecular mechanisms regulation involving AQPs osmolytes, describe how dehydration contributes structural metabolic dysfunction across key biological compartments, kidney, brain, bone, skeletal muscle. Physiological hallmark intensifies inflammaging, accelerating tissue degeneration. In particular, we highlight impairs solvent capacity, solute transport, protein conformation, communication. Despite known macronutrients geriatric nutrition, hydration remains an often-overlooked factor aging management. argue its inclusion fourth pillar nutritional approach veterinary geriatrics, alongside protein, fat, fiber. By investigating aging-associated dogs—species that share environments lifestyle patterns humans—we propose hydration-centered strategies promote healthy comparative medicine.

Язык: Английский

Not Only Anxiety, Preliminary Data on New Clinical Applications of Anxiety Wrap DOI
Stefania Uccheddu

Animal Behaviour and Welfare Cases, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Abstract In humans, pressure vests have been shown to reduce sympathetic arousal and increase parasympathetic activity, leading potential improvements. This suggests that stimulation may induce calming states through limbic hippocampal modulation. While anecdotally used as supportive therapy for children with autistic disorders dogs anxiety, rigorous scientific evidence is lacking support their efficacy in clinical management. a preliminary trial, we applied vest several hospitalized the intensive care unit manage anxiety. Some cases are here reported. these results promising, controlled, randomized trials needed confirm safety of this therapy. Nevertheless, given absence established treatment protocols, exploring benefits represents promising avenue future research improving experience specific situational or generalized Information © The Author 2025

Язык: Английский

Процитировано

0
The Emerging Role of Water Loss in Dog Aging DOI Creative Commons
Gabriella Guelfi, Camilla Capaccia,

Vicente Francisco Ratto

и другие.

Cells, Год журнала: 2025, Номер 14(7), С. 545 - 545

Опубликована: Апрель 4, 2025

Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores emerging role loss as a central underestimated driver functional decline in aging, with focus on dog, both clinically relevant target species model human aging. Age-related alterations metabolism—driven by changes body composition, aquaporin (AQP) expression, electrolyte imbalances, reduced thirst perception, impaired urine concentration—lead to intracellular extracellular dehydration, exacerbating decline. We examine molecular mechanisms regulation involving AQPs osmolytes, describe how dehydration contributes structural metabolic dysfunction across key biological compartments, kidney, brain, bone, skeletal muscle. Physiological hallmark intensifies inflammaging, accelerating tissue degeneration. In particular, we highlight impairs solvent capacity, solute transport, protein conformation, communication. Despite known macronutrients geriatric nutrition, hydration remains an often-overlooked factor aging management. argue its inclusion fourth pillar nutritional approach veterinary geriatrics, alongside protein, fat, fiber. By investigating aging-associated dogs—species that share environments lifestyle patterns humans—we propose hydration-centered strategies promote healthy comparative medicine.

Язык: Английский

Процитировано

0