Homocysteine Mediates Cognitive Inflexibility Induced by Stress via Targeting PIN1 DOI Creative Commons
Xiaobing Chen, Ling Zhang, Bing Liu

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 416 - 416

Опубликована: Апрель 19, 2025

Background: Increasing evidence shows that HCY plays an important role in stress-induced cognitive dysfunction, and significantly promotes the decline of function. Stress has been reported to cause elevated hippocampus mice. Cognitive flexibility refers ability individuals quickly adjust their neurobehavioral strategies different situations or solve tasks. Aims: This study aims explore impairment induced by stress its possible regulatory mechanism. Methods: First, we examined changes protein mRNA levels effector molecule, PIN1, during The results show can a mice lead increase PIN1. Moreover, through use vitro experiments, found could induce PIN1 expression neurons. Further vivo experiments were used investigate effect VitB on evaluated therapeutic flexibility. decreased plasma hippocampus, alleviated flexibility, reduced Conclusions: These suggest be inhibited regulating content HCY. Collectively, our findings highlight aimed at improving treatment for impairments

Язык: Английский

Homocysteine Mediates Cognitive Inflexibility Induced by Stress via Targeting PIN1 DOI Creative Commons
Xiaobing Chen, Ling Zhang, Bing Liu

и другие.

Brain Sciences, Год журнала: 2025, Номер 15(4), С. 416 - 416

Опубликована: Апрель 19, 2025

Background: Increasing evidence shows that HCY plays an important role in stress-induced cognitive dysfunction, and significantly promotes the decline of function. Stress has been reported to cause elevated hippocampus mice. Cognitive flexibility refers ability individuals quickly adjust their neurobehavioral strategies different situations or solve tasks. Aims: This study aims explore impairment induced by stress its possible regulatory mechanism. Methods: First, we examined changes protein mRNA levels effector molecule, PIN1, during The results show can a mice lead increase PIN1. Moreover, through use vitro experiments, found could induce PIN1 expression neurons. Further vivo experiments were used investigate effect VitB on evaluated therapeutic flexibility. decreased plasma hippocampus, alleviated flexibility, reduced Conclusions: These suggest be inhibited regulating content HCY. Collectively, our findings highlight aimed at improving treatment for impairments

Язык: Английский

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