Journal of Healthcare Sciences,
Год журнала:
2023,
Номер
3(12), С. 631 - 638
Опубликована: Янв. 1, 2023
Allergic
rhinitis
is
a
prevalent
upper
airway
inflammatory
disease
that
especially
widespread
in
the
paediatric
population.
In
medium-
to
long-term,
allergic
can
have
significant
impact
on
quality
of
life,
sleep,
and
everyday
functioning.
Watery
rhinorrhea,
nasal
congestion
obstruction,
sneezing,
itch
are
hallmark
clinical
manifestations
rhinitis.
The
diagnosis
based
thorough
history,
chest
examination,
tests
for
certain
immunoglobulin
E.
Usually,
coexists
with
other
diseases,
including
asthma
conjunctivitis.
Asthma
conditions
often
coexist.
literature,
this
idea
has
been
referred
as
unified
disease.
According
epidemiological
research,
common
co-occurring
condition
most
patients,
having
increases
chance
developing
asthma.
Patients
similar
physiologies.
Avoiding
allergens
trigger
using
pharmacological
therapies
accordance
guidelines
essential
its
proper
management.
A
tripartite
treatment
plan
incorporating
treatment,
immunotherapy,
environmental
control
recommended
optimal
management
However,
sole
cause
still
allergen-specific
immunotherapy
various
nutraceuticals
employed
symptomatic
relief.
Allergic
rhinitis
(AR)
is
a
disease
that
has
significant
effects
on
the
quality
of
life
people
and
exhibits
different
phenotypic
features
with
clinical
findings.
By
analyzing
data
pediatric
patients,
we
aimed
to
reveal
relationship
between
demographic
laboratory
gain
awareness
about
allergic
phenotypes
in
children.
Demographic
data,
complaints,
physical
examination
findings,
atopy
biomarkers
are
retrospectively
analyzed
assess
impact
aeroallergens
phenotype.
In
study
301
AR
patients
(median
age
11
years;
66.1%
male),
sneezing
(79.1%)
was
most
common
complaint,
pallor
nasal
mucosa
primary
finding
(83.1%).
Persistent
symptoms
were
reported
by
62.1%,
60.5%
polysensitized.
Notably,
42.5%
had
asthma,
often
associated
concurrent
sensitization
mold
or
animal
dander
(p
≤
0.05).
Pollen
prevalent
allergen
(65.8%),
increases
pollen
<
0.001)
=
0.003)
age.
Patients
more
0.026)
persistent
Nasal
congestion
predominantly
seen
house
dust
mite-sensitized
(78.4%
concha
hypertrophy,
p
0.001).
Overall,
it
found
59.7%
monosensitized
63.7%
polysensitized
complaints.
This
study,
conducted
Western
Turkey
revealed
high
prevalence
polysensitization,
particularly
dander.
Polysensitized
older,
exhibited
higher
IgE
levels,
frequently
rhinorrhea.
Furthermore,
polysensitization
linked
severe
symptoms,
emphasizing
need
for
personalized
treatment
strategies
these
patients.
Our
findings
highlight
importance
developing
individualized
region-specific
approaches
enhance
effectiveness
management.
Recent
research
advancements
have
enhanced
our
understanding
of
the
lymphatic
system
in
eye
and
nasal
region
its
involvement
health
disease.
The
is
an
anatomical
extension
central
nervous
was
previously
believed
to
be
devoid
structures,
except
for
conjunctiva.
However,
Lymphatic
vessels
been
recently
identified
cornea
(under
pathological
conditions),
limbus,
ciliary
body,
extraocular
muscles,
conjunctiva,
lacrimal
gland,
optic
nerve
sheath,
lymphoid
structures
choroid
Schlemm's
duct.
These
novel
findings
significant
implications
disease
treatment;
however,
mechanisms
by
which
they
preserve
immune
balance
eliminate
metabolic
waste
inflammatory
cells
remain
nebulous.
Furthermore,
connections
observed
between
ocular
via
network
accompanying
nasolacrimal
are
primary
pathway
cerebrospinal
fluid
drainage
a
new
route
drug
delivery
treatment
brain-related
diseases.
This
review
provides
overview
recent
structure
function
systems
their
association
with
various
Journal of Inflammation Research,
Год журнала:
2025,
Номер
Volume 18, С. 3981 - 3992
Опубликована: Март 1, 2025
The
objective
of
our
study
was
to
exploit
the
potential
mechanism
microRNA-126-5p
(miR-126-5p)
in
occurrence
and
formation
allergic
rhinitis
(AR)
children.
Nasal
mucosal
tissues
were
obtained
from
AR
children
patients
with
adenoidectomy.
Human
nasal
epithelial
cell
line
(RPMI-2650)
BALB/c
mice
models
were,
respectively,
established
via
ovalbumin
(OVA)
stimulation.
Target
genes
proteins
levels
determined
through
quantitative
real-time
polymerase
chain
reaction
(qRT-PCR)
enzyme-linked
immunosorbent
assay
(ELISA)
assays.
interaction
miR-126-5p
homeodomain-interacting
protein
kinase
2
(HIPK2)
confirmed
dual-luciferase
reporter
detection.
MiR-126-5p
memorably
increased
tissue
specimens
compared
adenoidectomy,
while
HIPK2
distinctly
declined
(all
P<0.05).
A
negative
association
found
between
expression
(r=-0.5757,
P<0.001).
Moreover,
predicted
be
targeted
by
miR-126-5p.
Proinflammatory
cytokines
expressions
significantly
increased,
anti-inflammatory
obviously
decreased
RPMI-2650
model
(P<0.001).
NF-κB
signaling
pathway
also
activated
model.
inhibitor
mitigated
stimulated
function
OVA.
Silencing
recused
phenomena
Furthermore,
vivo
experiments
further
verified
vitro
results,
documenting
that
si-HIPK2
relieved
down-regulation
inflammation
response
events
HIPK2/NF-κB
pathway,
suggesting
being
a
latent
therapeutic
target
AR.
Minerva Pediatrics,
Год журнала:
2024,
Номер
76(4)
Опубликована: Фев. 26, 2024
Allergic
rhinitis
(AR)
is
a
prevalent
disease
in
childhood
and
adolescence.
A
type
2
inflammation
characterizes
AR
and,
mainly,
sustains
nasal
obstruction.
Budesonide
aqueous
spray
(BANS)
an
intranasal
corticosteroid
(INCS)
available
since
the
early
1980s.
BANS
indicated
for
treating
allergic
rhinitis.
There
evidence
about
its
efficacy
children
adolescents
with
seasonal
perennial
AR.
In
addition,
safe
negligible
local
systemic
side
effects.
Recent
guidelines
patients
recommend
use
of
INCS
as
first
line
many
situations.
particular,
(and
their
parents)
may
assess
perception
symptoms'
severity
using
Visual
Analog
Scale
(VAS).
score
≥5/10
means
uncontrolled
symptoms
requires
adequate
treatment.
could
appropriately
be
used
and/or
moderate/severe
conclusion,
represents
valuable
option
managing
