Advances in Therapy, Год журнала: 2023, Номер 41(2), С. 847 - 856
Опубликована: Ноя. 27, 2023
Язык: Английский
Scientific Reports, Год журнала: 2023, Номер 13(1)
Опубликована: Авг. 1, 2023
Abstract One of the major challenges currently faced by global health systems is prolonged COVID-19 syndrome (also known as “long COVID”) which has emerged a consequence SARS-CoV-2 epidemic. It estimated that at least 30% patients who have had will develop long COVID. In this study, our goal was to assess plasma metabolome in total 100 samples collected from healthy controls, patients, and COVID recruited Mexico between 2020 2022. A targeted metabolomics approach using combination LC–MS/MS FIA MS/MS performed quantify 108 metabolites. IL-17 leptin were measured immunoenzymatic assay. The comparison paired COVID-19/long revealed 53 metabolites statistically different. Compared 27 remained dysregulated even after two years. Post-COVID-19 displayed heterogeneous metabolic profile. Lactic acid, lactate/pyruvate ratio, ornithine/citrulline arginine identified most relevant for distinguishing with more complicated evolution. Additionally, levels significantly increased these patients. Mitochondrial dysfunction, redox state imbalance, impaired energy metabolism, chronic immune dysregulation are likely be main hallmarks years acute infection.
Язык: Английский
Процитировано
54
Acta Neuropathologica Communications, Год журнала: 2023, Номер 11(1)
Опубликована: Май 10, 2023
Abstract Introduction COVID-19-infected patients harbour neurological symptoms such as stroke and anosmia, leading to the hypothesis that there is direct invasion of central nervous system (CNS) by SARS-CoV-2. Several studies have reported neuropathological examination brain samples from who died COVID-19. However, still sparse evidence virus replication in human brain, suggesting neurologic could be related mechanisms other than CNS infection virus. Our objective was provide an extensive review literature on findings postmortem COVID-19 report our own experience with 18 samples. Material methods We used microscopic examination, immunohistochemistry (using two different antibodies) PCR-based techniques describe presence SARS-CoV-2 For comparison, similar (IHC PCR) were applied lung tissue for each patient cohort. The systematic conducted beginning pandemic 2019 until June 1st, 2022. Results In cohort, most common perivascular haemosiderin-laden macrophages hypoxic-ischaemic changes neurons, which found all cases (n = 18). Only one sample harboured viral spike nucleocapsid protein expression, while RNA positivity PCR. A colocalization study revealed antigens located macrophages. highlighted frequent ischaemic haemorrhagic lesions, including hypoxic/ischaemic alterations. few confirmed Conclusion This lack specific alterations patients. There no neurotropism cohort or literature.
Язык: Английский
Процитировано
18
Zeitschrift für Neuropsychologie, Год журнала: 2023, Номер 34(2), С. 57 - 70
Опубликована: Май 24, 2023
Abstract: Cognitive sequelae after recovery from an initial COVID-19 disease are present in a subset of affected individuals, coalescing around several important issues such as effects age, severity, comorbidities, and other factors. Some neuropsychological symptoms appear more common among certain patient populations. Comorbidities may complicate assessment well. Hence, we need guideline-based evaluation to guide rehabilitation. Drawing the recent revision German National Guideline for Long- Post-COVID Syndrome current advances international guidance on assessment, this article provides practical scientifically informed recommendations individuals recovering coronavirus-related diseases.
Язык: Английский
Процитировано
13
Reumatologia/Rheumatology, Год журнала: 2024, Номер 61(6), С. 492 - 501
Опубликована: Янв. 18, 2024
Numerous hypotheses regarding the pathogenetic mechanisms of long COVID have been proposed. Immune dysregulation and autoimmunity are among leading hypotheses. In this article, we pre-sent two clinical cases COVID. The first case demonstrates phenotype with pain musculoskeletal symptoms, which is often associated mimics systemic connective tissue diseases. second case, a high titer antinuclear antibodies was observed after SARS-CoV-2 infection, but symptoms were limited to fever headache. Only comprehensive evaluation thorough objective examination can con-firm or exclude autoimmune diseases previous infection. A systematic search in PubMed Medline database carried out for studies focusing on immune dysregulation, auto-immunity, its association question role development management approaches discussed.
Язык: Английский
Процитировано
4
Frontiers in Immunology, Год журнала: 2024, Номер 14
Опубликована: Фев. 19, 2024
The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented concentration of economic and research efforts to generate knowledge at unequalled speed on deregulated interferon type I signalling nuclear factor kappa light chain enhancer in B-cells (NF-κB)-driven interleukin (IL)-1β, IL-6, IL-18 secretion causing cytokine storms. translation the how resulting systemic inflammation can lead life-threatening complications into novel treatments vaccine technologies is underway. Nevertheless, previously existing role cytoplasmatic or circulating self-DNA as a pro-inflammatory damage-associated molecular pattern (DAMP) was largely ignored. Pathologies reported ‘ de novo ’ for patients infected with Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 be outcomes self-DNA-driven fact had been linked earlier different contexts, e.g., infection Human Immunodeficiency Virus (HIV)-1, sterile inflammation, autoimmune diseases. highlight particularly synergies other DAMPs render immunogenic properties normally non-immunogenic extracellular self-DNA, discuss shared features gp41 unit HIV-1 envelope protein SARS-CoV 2 Spike that enable SARS-CoV-2 interact cell membranes, trigger syncytia formation, inflict damage their host’s DNA, – likely own benefit. These similarities motivate speculations similar mechanisms those driven by explain inflammatory contributes some most frequent adverse events after vaccination BNT162b2 mRNA (Pfizer/BioNTech) mRNA-1273 (Moderna) vaccine, i.e., myocarditis, herpes zoster, rheumatoid arthritis, nephritis hepatitis, new-onset lupus erythematosus, flare-ups psoriasis lupus. hope wider application lessons learned from experiences COVID-19 new vaccines combat future non-COVID-19
Язык: Английский
Процитировано
4
Virology Journal, Год журнала: 2025, Номер 22(1)
Опубликована: Янв. 13, 2025
Abstract Background Primary Immunodeficiency disorders (PID) can increase the risk of severe COVID-19 and prolonged infection. This study investigates duration SARS-CoV-2 excretion genetic evolution virus in pediatric PID patients as compared to immunocompetent (IC) patients. Materials methods A total 40 nasopharyngeal 24 stool samples were obtained from five ten IC children. RNA detection was performed using RT-qPCR, whole-genome sequencing conducted with NexSeq 1000 platform. Data analysis used nextflow/viralrecon pipeline. Hotspot amino acid frequencies investigated GraphPad Prism v10. Phylodynamic BEAST software. Results In children, viral period lasted up 14 days swabs, an average 7 days, ranged samples. patients, detected for periods between 28 15 Two variants patients: Delta (AY.122) Omicron (BA.1.1). Patients antibody combined deficiencies, exhibited most shedding both one patient presented complications fatal outcome. Specific changes PID: A2821V R550H (ORF1ab). Conclusion Our findings underscore deficiencies. Thus, specialized care is essential effectively managing
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 862 - 862
Опубликована: Янв. 20, 2025
Vaccines represent an essential tool for the prevention of infectious diseases. Upon administration, a complex interaction occurs between vaccine formulation and recipient’s immune system, ultimately resulting in protection against disease. Significant variability exists individual population responses to vaccination, these differences remain focus ongoing research. Notably, well-documented factors, such as age, gender, genetic predisposition, influence responses. In contrast, effects overweight obesity have not been thoroughly investigated. The evidence indicates that high body mass index (BMI) constitutes significant risk factor infections general, with adipose tissue playing crucial role modulating response. Furthermore, suboptimal levels seroconversion observed among individuals obesity. This review provides plausible examination immunity conferred by various vaccines status, offering comprehensive analysis mechanisms enhance vaccination efficiency.
Язык: Английский
Процитировано
0
Irish Journal of Medical Science (1971 -), Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
The SARS-CoV-2 virus, responsible for COVID-19, has the potential to induce formation of antibodies that target self-antigens. This study aimed investigate prevalence antinuclear (ANA), most common type autoantibody, in both healthy individuals and those recovered from COVID-19. retrospective involved 400 participants (200 with COVID-19 200 controls), aged 18 60 years, without any chronic diseases, including autoimmune conditions. Analyses were performed using three different ANA ELISA test kits (anti-dsDNA, anti-ENA, anti-Hep-2 nucleus tests) developed validated. Among individuals, 38 (19%) tested positive dsDNA, 37 (18.5%) ENA, 30 (15%) Hep-2 antibodies. rates positivity significantly higher 97 (48.5%) 81 (40.5%) 84 (42%) (p < 0.05). One every two exhibited positivity, indicating virus poses a significant risk regarding autoimmunity. Furthermore, incidence was observed be than literature average.
Язык: Английский
Процитировано
0
Allergy, Год журнала: 2025, Номер unknown
Опубликована: Март 14, 2025
ABSTRACT An estimated 10% of coronavirus disease (COVID‐19) survivors suffer from persisting symptoms referred to as long COVID (LC), a condition for which approved treatment options are still lacking. This systematic review (PROSPERO: CRD42024499281) aimed explore the pathophysiological mechanisms underlying LC and potential treatable traits across symptom‐based phenotypes. We included studies with primary data, written in English, focusing on omics analyses human samples patients persistent at least 3 months. Our search PubMed Embase, conducted January 8, 2024, identified 642 studies, 29 met inclusion criteria after full‐text assessment. The risk bias was evaluated using Joanna Briggs Institute appraisal tool. synthesis including genomics, transcriptomics, proteomics, metabolomics, metagenomics, revealed common findings associated fatigue, cardiovascular, pulmonary, neurological, gastrointestinal Key mitochondrial dysfunction, dysregulated microRNAs pulmonary tissue impairment, blood–brain barrier disruption, coagulopathy, vascular microbiome disturbances, microbial‐derived metabolite production inflammation. Limitations include cross‐study heterogeneity variability sampling methods. emphasizes complexity need further longitudinal omics‐integrated advance development biomarkers targeted treatments.
Язык: Английский
Процитировано
0
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4894 - 4894
Опубликована: Март 3, 2023
Strategies concerning thyroid anomalies in patients confirmed with psoriasis, either on clinical level or molecular levels, and their genetic findings remain an open issue. Identification of the exact subgroup individuals that are candidates to endocrine assessments is also controversial. Our purpose this work was overview pathogenic data psoriasis comorbidities from a dual perspective (dermatologic endocrine). This narrative review English literature between January 2016 2023. We included clinically relevant, original articles different levels statistical evidence published PubMed. followed four clusters conditions: dysfunction, autoimmunity, cancer, subacute thyroiditis. A new piece information field fact autoimmune diseases (ATD) have been shown be related immune-based side effects modern anticancer drugs-namely, immune checkpoint inhibitors (ICP). Overall, we identified 16 confirmatory studies, but heterogeneous data. Psoriatic arthritis had higher risk positive antithyroperoxidase antibodies (TPOAb) (25%) compared cutaneous control. There increased dysfunction versus control, hypothyroidism most frequent type (subclinical rather than clinical), among correlated >2-year disease duration, peripheral > axial polyarticular involvement. With few exceptions, there female predominance. Hormonal imbalance included, frequently, low thyroxine (T4) and/or triiodothyronine (T3) normal stimulating hormone (TSH), by high TSH (only one study total T3). The highest ratio involvement dermatologic subtypes 59% for erythrodermic psoriasis. Most studies found no correlation severity. Statistically significant odds ratios were as follows: hypothyroidism: 1.34-1.38; hyperthyroidism: 1.17-1.32 (fewer hypo); ATD: 1.42-2.05; Hashimoto's thyroiditis (HT): 1.47-2.09; Graves' disease: 1.26-1.38 HT). 8 inconsistent correlations, while lowest rate 8% (uncontrolled studies). Other 3 ATD looking well 1 cancer. ICP potentially exacerbate prior induce them both de novo (5 At case report level, showed due biological medication (ustekinumab, adalimumab, infliximab). Thyroid thus remained puzzling. observed identifying especially hypothyroidism, these subjects. Awareness will necessary improve overall outcomes. profile diagnosed who should screened endocrinology team still matter debate, terms dermatological subtype, activity, other synchronous (especially autoimmune) conditions.
Язык: Английский
Процитировано
7