ULK2 suppresses ovarian cancer cell migration and invasion by elevating IGFBP3 DOI Creative Commons
Xiaoxi Chen,

Changxiang Shao,

Jing Liu

и другие.

PeerJ, Год журнала: 2024, Номер 12, С. e17628 - e17628

Опубликована: Июнь 28, 2024

Background Ovarian cancer is an aggressive malignancy with high mortality known for its considerable metastatic potential. This study aimed to explore the expression and functional role of Unc-51 like autophagy activating kinase 2 (ULK2) in progression ovarian cancer. Methods ULK2 patterns tissues as well benign tumor control samples obtained from our institution were evaluated using immunohistochemistry. Cell counting kit 8 Transwell assays applied assess effects overexpression on cell proliferation, migration invasion, respectively. RNA sequencing was performed potential mechanisms action beyond classical modulation. Results Our experiments showed significant downregulation tissues. Importantly, low markedly correlated decreased overall survival. In vitro studies further demonstrated that significantly suppressed migration, invasion. analysis revealed a regulatory insulin signaling pathway through upregulation insulin-like growth factor binding protein-3 (IGFBP3) cells. Conclusions summary, collective data indicated acted suppressor by upregulating IGFBP3. underscores utility valuable prognostic marker

Язык: Английский

Transcriptional regulation of ATOX1 by PRRX2 impacts the progression and cuproptosis of hepatocellular carcinoma DOI
Ling Tang, Bin Xie,

Xiankui Cao

и другие.

Cellular Signalling, Год журнала: 2025, Номер unknown, С. 111883 - 111883

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Aberrant activation of a miR-101–UBE2D1 axis contributes to the advanced progression and chemotherapy sensitivity in human hepatocellular carcinoma DOI Creative Commons

Xiuli Mu,

Yuchen Wei, Xinxiang Fan

и другие.

Cell Death Discovery, Год журнала: 2024, Номер 10(1)

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

1
ULK2 suppresses ovarian cancer cell migration and invasion by elevating IGFBP3 DOI Creative Commons
Xiaoxi Chen,

Changxiang Shao,

Jing Liu

и другие.

PeerJ, Год журнала: 2024, Номер 12, С. e17628 - e17628

Опубликована: Июнь 28, 2024

Background Ovarian cancer is an aggressive malignancy with high mortality known for its considerable metastatic potential. This study aimed to explore the expression and functional role of Unc-51 like autophagy activating kinase 2 (ULK2) in progression ovarian cancer. Methods ULK2 patterns tissues as well benign tumor control samples obtained from our institution were evaluated using immunohistochemistry. Cell counting kit 8 Transwell assays applied assess effects overexpression on cell proliferation, migration invasion, respectively. RNA sequencing was performed potential mechanisms action beyond classical modulation. Results Our experiments showed significant downregulation tissues. Importantly, low markedly correlated decreased overall survival. In vitro studies further demonstrated that significantly suppressed migration, invasion. analysis revealed a regulatory insulin signaling pathway through upregulation insulin-like growth factor binding protein-3 (IGFBP3) cells. Conclusions summary, collective data indicated acted suppressor by upregulating IGFBP3. underscores utility valuable prognostic marker

Язык: Английский

Процитировано

0