Oxidative-Stress-Mediated Epigenetic Dysregulation in Spermatogenesis: Implications for Male Infertility and Offspring Health
Genes,
Год журнала:
2025,
Номер
16(1), С. 93 - 93
Опубликована: Янв. 17, 2025
Male
reproductive
health
is
governed
by
an
intricate
interplay
of
genetic,
epigenetic,
and
environmental
factors.
Epigenetic
mechanisms—encompassing
DNA
methylation,
histone
modifications,
non-coding
RNA
activity—are
crucial
both
for
spermatogenesis
sperm
maturation.
However,
oxidative
stress,
driven
excessive
reactive
oxygen
species,
disrupts
these
processes,
leading
to
impaired
function
male
infertility.
This
disruption
extends
epigenetic
resulting
in
abnormal
gene
expression
chromatin
remodeling
that
compromise
genomic
integrity
fertilization
potential.
Importantly,
oxidative-stress-induced
alterations
can
be
inherited,
affecting
the
fertility
offspring
future
generations.
review
investigates
how
stress
influences
regulation
reproduction
modifying
RNAs,
ultimately
compromising
spermatogenesis.
Additionally,
it
discusses
transgenerational
implications
disruptions
their
potential
role
hereditary
infertility
disease
predisposition.
Understanding
mechanisms
vital
developing
therapeutic
strategies
mitigate
damage
restore
homeostasis
germline.
By
integrating
insights
from
molecular,
clinical,
research,
this
work
emphasizes
need
targeted
interventions
enhance
prevent
adverse
outcomes
progeny.
Furthermore,
elucidating
dose–response
relationships
between
changes
remains
a
critical
research
priority,
informing
personalized
diagnostics
interventions.
In
context,
studies
should
adopt
standardized
markers
damage,
robust
clinical
trials,
multi-omic
approaches
capture
complexity
Such
rigorous
investigations
will
reduce
risk
disorders
optimize
outcomes.
Язык: Английский
Epigenetic aging of semen is associated with inflammation
Epigenetics,
Год журнала:
2024,
Номер
19(1)
Опубликована: Дек. 5, 2024
Male
infertility
has
been
a
primary
cause
of
global
infertility,
affecting
8–12%
couples
worldwide.
Previous
studies
have
shown
that
semen
quality
decreases
with
advanced
aging
an
increased
presence
inflammatory
cells.
In
this
study,
we
examined
changes
in
the
epigenome
across
diverse
cohort
includes
both
fertile
and
infertile
men.
We
also
compare
age-associated
to
those
observed
buccal
swabs
order
characterize
differences
epigenetic
tissues.
found
variations
methylome
associated
are
linked
genes.
Many
sites
demethylated
activation
pathways.
By
contrast,
do
not
observe
genes
swab
methylomes,
which
instead
characterized
by
bivalent
promoters.
Our
findings
highlight
potential
markers
as
indicators
male
reproductive
health.
Язык: Английский