Anastasis and Other Apoptosis-Related Prosurvival Pathways Call for a Paradigm Shift in Oncology: Significance of Deintensification in Treating Solid Tumors
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1881 - 1881
Опубликована: Фев. 22, 2025
What
is
apoptosis?
The
Nomenclature
Committee
on
Cell
Death
and
numerous
other
pioneering
cancer/p53
biologists
use
the
terms
"apoptosis"
"cell
death"
interchangeably,
disregard
mind-numbing
complexity
heterogeneity
that
exists
within
a
tumor
(intratumor
heterogeneity),
contribution
of
polyploid
giant
cancer
cells
(PGCCs;
root
causes
therapy
resistance
relapse)
to
this
heterogeneity,
then
propose
novel
apoptosis-stimulating
anticancer
strategies.
This
shocking
for
following
three
reasons.
First,
clinical
studies
reported
since
1990s
have
revealed
increased
apoptosis
in
solid
tumors
associated
with
diversity
poor
prognosis.
Second,
we
known
years
dying
(apoptotic)
release
panel
secretions
(e.g.,
via
phoenix
rising
pathways)
promote
metastatic
outgrowth.
Third,
over
decade
ago,
it
was
demonstrated
can
recover
from
late
stages
(after
formation
apoptotic
bodies)
homeostatic
process
anastasis,
resulting
emergence
aggressive
variants.
cell
surface
expression
CD24
has
recently
been
be
preferentially
enriched
recovered
(anastatic)
exhibit
tumorigenic
properties.
These
related
discoveries
outlined
herein
call
paradigm
shift
oncology
focus
strategies
minimize
occurrence
treacherous
tumor-repopulating
events
therapy-induced
dormancy
reactivation).
They
also
raise
an
intriguing
question:
deregulated
anastasis
(rather
than
evasion
apoptosis)
hallmark
cancer?
Язык: Английский
Integrating frontiers: a holistic, quantum and evolutionary approach to conquering cancer through systems biology and multidisciplinary synergy
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Авг. 19, 2024
Cancer
therapy
is
facing
increasingly
significant
challenges,
marked
by
a
wide
range
of
techniques
and
research
efforts
centered
around
somatic
mutations,
precision
oncology,
the
vast
amount
big
data.
Despite
this
abundance
information,
quest
to
cure
cancer
often
seems
more
elusive,
with
“war
on
cancer”
yet
deliver
definitive
victory.
A
particularly
pressing
issue
development
tumor
treatment
resistance,
highlighting
urgent
need
for
innovative
approaches.
Evolutionary,
Quantum
Biology
System
offer
promising
framework
advancing
experimental
research.
By
integrating
theoretical
studies,
translational
methods,
flexible
multidisciplinary
clinical
research,
there’s
potential
enhance
current
strategies
improve
outcomes
patients.
Establishing
stronger
links
between
evolutionary,
quantum,
entropy
chaos
principles
oncology
could
lead
effective
treatments
that
leverage
an
understanding
tumor’s
evolutionary
dynamics,
paving
way
novel
methods
control
mitigate
cancer.
Achieving
these
objectives
necessitates
commitment
interprofessional
collaboration
at
heart
both
endeavors
in
oncology.
This
entails
dismantling
silos
disciplines,
encouraging
open
communication
data
sharing,
diverse
viewpoints
expertise
from
outset
projects.
Being
receptive
new
scientific
discoveries
responsive
how
patients
react
also
crucial.
Such
are
key
keeping
field
forefront
management,
ensuring
receive
most
personalized
care.
Ultimately,
approach
aims
push
boundaries
understanding,
treating
it
as
manageable
chronic
condition,
aiming
extend
life
expectancy
patient
quality
life.
Язык: Английский
The Spiral Model of Evolution: Stable Life Forms of Organisms and Unstable Life Forms of Cancers
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9163 - 9163
Опубликована: Авг. 23, 2024
If
one
must
prioritize
among
the
vast
array
of
contributing
factors
to
cancer
evolution,
environmental-stress-mediated
chromosome
instability
(CIN)
should
easily
surpass
individual
gene
mutations.
CIN
leads
emergence
genomically
unstable
life
forms,
enabling
them
grow
dominantly
within
stable
form
host.
In
contrast,
stochastic
mutations
play
a
role
in
aiding
growth
population,
with
their
importance
depending
on
initial
new
system.
Furthermore,
many
specific
available
can
perform
this
function,
decreasing
clinical
value
any
mutation.
Since
these
forms
respond
treatment
differently
than
ones,
often
escapes
from
drug
by
forming
systems,
which
problems
during
for
patients.
To
understand
how
diverse
impact
CIN-mediated
macroevolution
and
genome
integrity–ensured
microevolution,
concept
two-phased
evolution
is
used
reconcile
some
major
characteristics
cancer,
such
as
bioenergetic,
unicellular,
multicellular
evolution.
Specifically,
spiral
function
model
proposed,
integrates
historical
evolutionary
innovations
conservation
information
management.
Unlike
normal
organismal
microevolutionary
phase,
where
given
species
occupies
location
spiral,
populations
are
highly
heterogenous
at
multiple
levels,
including
epigenetic
levels.
Individual
cells
occupy
different
levels
positions
leading
supersystems
mixed
cellular
that
exhibit
both
macro
microevolution.
This
analysis,
utilizing
karyotype
define
genetic
networks
system
determine
system,
well
considering
mutation
epigenetics
modifiers
amplification
usage,
explores
high
potential
cancer.
It
provides
new,
unified
understanding
supersystem,
encouraging
efforts
leverage
dynamics
develop
improved
options.
Moreover,
it
offers
historically
contingent
reconciles
roles
innovation
through
respectively.
Язык: Английский
Amitotic Cell Division, Malignancy, and Resistance to Anticancer Agents: A Tribute to Drs. Walen and Rajaraman
Cancers,
Год журнала:
2024,
Номер
16(17), С. 3106 - 3106
Опубликована: Сен. 8, 2024
Cell
division
is
crucial
for
the
survival
of
living
organisms.
Human
cells
undergo
three
types
cell
division:
mitosis,
meiosis,
and
amitosis.
The
former
two
occur
in
somatic
germ
cells,
respectively.
Amitosis
involves
nuclear
budding
occurs
that
exhibit
abnormal
morphology
(e.g.,
polyploidy)
with
increased
size.
In
early
2000s,
Kirsten
Walen
Rengaswami
Rajaraman
his
associates
independently
reported
polyploid
human
are
capable
producing
progeny
via
amitotic
division,
a
subset
emerging
daughter
proliferate
rapidly,
stem
cell-like
properties,
can
contribute
to
tumorigenesis.
Polyploid
arise
solid
tumors/tumor-derived
lines
referred
as
giant
cancer
(PGCCs)
known
therapy
resistance
disease
recurrence
following
anticancer
treatment.
This
commentary
provides
an
update
on
some
these
intriguing
discoveries
tribute
Drs.
Rajaraman.
Язык: Английский