Association of Oxidative Stress Markers with Incident Hyperglycemia in Gestational Diabetes Mellitus in an Educational Intervention

Nutrients, Год журнала: 2025, Номер 17(4), С. 680 - 680

Опубликована: Фев. 14, 2025

This study is aimed to assess the link between oxidative stress markers and incident hyperglycemia in women with gestational diabetes mellitus (GDM) during an educational intervention. The used a prospective cohort. Pregnant GDM who were 18-40 years old (n = 201) participated 18-month postpartum intervention emphasizing healthy practices (nutrition, breastfeeding, physical activity, psychosocial support). tested oral glucose tolerance test (OGTT) after third month postpartum, classified as follows: (1) (IHypergly) 86) if they had fasting plasma (FPG) of 100-125 mg/dL, impaired 2 h (140-199 mg/dL), or type (T2D) FPG ≥ 126 ≥200 mg/dL (2 h); (2) without 115) < 100 <140 post-OGTT. Participants evaluated at end pregnancy post-intervention. Clinical, biochemical, anthropometric, dietary, data (malondialdehyde, reduced glutathione, antioxidant capacity, carbonylated proteins, adiponectin) recorded. Multivariate logistic regression analysis identified association GDM. A total 6% progressed T2D, 36.8% prediabetes. At baseline, Ihypergly exhibited elevated adiponectin, lower capacity. Post-intervention, showed higher GSH, MDA. Basal malondialdehyde, pregestational BMI, HbA1c, sugary food consumption positively correlated Ihypergly. high intake antioxidants inversely hyperglycemia. Higher concentrations are associated diabetes.

Язык: Английский

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Advances in the Insulin–Heart Axis: Current Therapies and Future Directions

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(18), С. 10173 - 10173

Опубликована: Сен. 22, 2024

The insulin–heart axis plays a pivotal role in the pathophysiology of cardiovascular disease (CVD) insulin-resistant states, including type 2 diabetes mellitus. Insulin resistance disrupts glucose and lipid metabolism, leading to systemic inflammation, oxidative stress, atherogenesis, which contribute heart failure (HF) other CVDs. This review was conducted by systematically searching PubMed, Scopus, Web Science databases for peer-reviewed studies published past decade, focusing on therapeutic interventions targeting axis. Studies were selected based their relevance insulin resistance, outcomes, efficacy pharmacologic treatments. Key findings from highlight lifestyle modifications, such as dietary changes physical activity, remain cornerstone managing improving outcomes. Moreover, interventions, metformin, sodium–glucose cotransporter inhibitors, glucagon-like peptide-1 receptor agonists, dipeptidyl peptidase-4 have shown reducing risk addressing metabolic dysfunction, endothelial function. Furthermore, emerging treatments, angiotensin receptor–neprilysin mechanical like ventricular assist devices offer new avenues HF patients. potential these therapies improve left ejection fraction reverse pathological cardiac remodeling highlights importance early intervention. However, challenges optimizing treatment regimens understanding long-term effects agents. Future research should focus personalized approaches that integrate effectively target mitigate burden complications populations.

Язык: Английский

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Impact of the KARAZ platform's behavioral interventions and incentives on diabetic glycemic control in Saudi Arabia

Digital Health, Год журнала: 2025, Номер 11

Опубликована: Март 1, 2025

Introduction The glucose management indicator (GMI) and time-in-range (TIR) are important glycemic parameters calculated from continuous monitoring (CGM) values. KARAZ, a hybrid Internet of things—artificial intelligence platform, was developed in Saudi Arabia to help manage diabetes mellitus. complex nature self-care behavior changes associated with mellitus requires breaking large behaviors into achievable ones related incentives. Aim This study explored how tiny habits as behavioral intervention incentive system affect control among KARAZ Platform users various age groups Arabia. Methods retrospective included analyzed the effects interventions incentives on GMI TIR parameters. Results Of 296 active users, 118 (40%) 148 (50%) maintained desirable GMI, respectively. Adult females aged ≥ 26 years who consistently followed exhibited significant reduction (5%). Intrinsic motivation through modification more effective than external for maintaining control. Conclusion findings highlight can impact suggesting their effectiveness promoting better health improving Arabian context. Further research should investigate these be sustainably without relying Recommendations discussed children Type 1 would benefit CGM connection iteration integration comprehensive care program within system.

Язык: Английский

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The combined effects of high-intensity interval training and time-restricted feeding on the AKT/FOXO1/PEPCK pathway in diabetic rats

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Апрель 22, 2025

High-intensity interval training (HIIT) and time-restricted feeding (TRF) have shown promise for improving glucose regulation by increasing insulin sensitivity, enhancing uptake, reducing production. Therefore, this study investigates the combined effects of HIIT TRF on AKT/FOXO1/PEPCK signaling pathway in liver tissue type 2 diabetic rats. 42 male Wistar rats (4-5 weeks age) were included study. The animals randomly divided into two groups: (1) Standard diet (SD, non-Diabetic (Non-D, n = 7) (2) High-fat (HFD, 35) 4 weeks. To induce diabetes, 35 mg/kg streptozotocin (STZ) was injected intraperitoneally (IP). Animals with blood levels > 250 mg/dL considered as diabetic. Diabetic 5 groups (n 7): Diabetes-exercise (D-EX), Diabetes-TRF (D-TRF), (3) Diabetes-combined exercise (D-TRF&EX), (4) Diabetes no treatment (D-NT), (5) metformin (D-MET). Interventions (HIIT TRF) performed 10 Rats Non-D group did not receive or TRF. Periodic Acid-Schiff (PAS) staining used to histologically analyze tissue. Levels glucose, resistance (IR), FOXO1 protein, PEPCK, area under curve (AUC) following IPGTT test, significantly decreased compared D-NT (p < 0.05). AKT protein 0.01), glycogen content 0.05), sensitivity 0.001) increased group. Microscopic examination general showed a better arrangement both than Combining may be effective regulation, interventions alone.

Язык: Английский

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The Role of Plant-Based Nutrition and Exercise in Metabolic Syndrome: A Narrative Review

Nutrients, Год журнала: 2025, Номер 17(9), С. 1498 - 1498

Опубликована: Апрель 29, 2025

Metabolic syndrome (MetS) is a prevalent health condition characterized by central obesity, insulin resistance, hypertension, and dyslipidemia, increasing the risk of cardiovascular disease type 2 diabetes. Lifestyle interventions, particularly plant-based nutrition exercise, are essential for managing MetS. While both strategies well-documented independently, their synergistic effects remain less explored. This narrative review integrates findings from domains to evaluate combined impact on metabolic syndrome. The examines individual impacts exercise MetS-related dysfunction. A comprehensive 114 peer-reviewed studies was conducted assess role diets structured physical activity in improving sensitivity, lipid profiles, inflammation, weight management. Studies investigating mechanisms through which dietary components modalities influence were analyzed, along with behavioral psychological factors affecting long-term adherence. Plant-based diets, those high fiber, polyphenols, healthy fats, improve glucose metabolism, reduce enhance health. Exercise complements these benefits promoting fat oxidation, metabolism. When combined, provide superior outcomes, including greater reductions visceral adiposity, improved endothelial function, enhanced glycemic control. effective Their highlight importance integrated lifestyle interventions

Язык: Английский

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Impacts of aging on brain metabolism

Progress in brain research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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The epigenetic impact of lifestyle factors on metabolic syndrome: A systematic review

Journal of Clinical Sciences, Год журнала: 2025, Номер 22(2), С. 108 - 118

Опубликована: Апрель 1, 2025

ABSTRACT Metabolic syndrome (MetS) is a cluster of metabolic abnormalities, including insulin resistance, obesity, dyslipidemia, and hypertension, increasing the risk cardiovascular disease diabetes. Lifestyle factors such as poor diet, sedentary behavior, smoking contribute to its rising prevalence. Emerging research suggests epigenetic modifications, DNA methylation, histone noncoding RNAs (ncRNAs), play crucial role in MetS. This review examines how lifestyle influence mechanisms that A comprehensive literature search was conducted using MEDLINE (via PubMed) Google Scholar, focusing on studies investigating effects physical activity, Relevant from reference lists were also included. Studies analyzing ncRNAs tissues prioritized. Exclusion criteria included lacking analysis or those unrelated Key data, findings, extracted, links between gene regulation. Poor diet induce modifications impair signaling, lipid metabolism, inflammation. Exercise balanced nutrition promote beneficial changes, enhancing mitochondrial function health. choices shape regulation influencing MetS risk. While habits worsen dysfunction, exercise proper can mitigate damage. Understanding these aid developing targeted interventions for prevention management.

Язык: Английский

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Risk of Insulin Resistance in 44,939 Spanish Healthcare Workers: Association with Sociodemographic Variables and Healthy Habits

Diseases, Год журнала: 2025, Номер 13(2), С. 33 - 33

Опубликована: Янв. 27, 2025

Introduction: Insulin resistance (IR) is a highly prevalent pathophysiological entity implicated in the development of wide variety metabolic, cardiovascular, and endocrine disorders. The aim this study to assess association between sociodemographic variables healthy habits with IR risk scales. Methodology: This dual study, incorporating both longitudinal-retrospective cross-sectional designs, analyzed healthcare workers across four professional categories (physicians, nurses, technicians, auxiliary personnel). It examined age, sex, category, smoking status, physical activity, adherence Mediterranean diet elevated scores on insulin Results: All were associated presence values scales, activity showing strongest (reflected odds ratio values). Conclusions: profile an individual higher presenting scales would be elderly male health worker who smoker physically inactive, low diet.

Язык: Английский

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Molecular Biology: Challenges and Opportunities

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 109 - 109

Опубликована: Фев. 9, 2025

“Latest Review Papers in Molecular Biology 2024”, a Special Issue of Current Issues (CIMB) that I have had the privilege editing, called for articles on challenges and opportunities field molecular biology [...]

Язык: Английский

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Association between the systemic immune-inflammation index and metabolic syndrome and its components: results from the multi-ethnic study of atherosclerosis (MESA)

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Фев. 15, 2025

The Systemic Immune-Inflammation Index (SII) is a novel biomarker of systemic inflammation. We explored the association between SII and metabolic syndrome (MetS) its components in middle-aged older adults. included 2755 participants (1305 men) aged 45–84 years from Multi-Ethnic Study Atherosclerosis (MESA) cohort examination 5 (2010–2012). Logistic regression was employed to assess relationship MetS, as well components. A total 1082 (463 were diagnosed with MetS. On continuous scale, positively associated MetS (odds ratio (OR): 1.23, 95% confidence interval (CI): 1.05–1.46) including hyperglycemia (1.23: 1.05–1.44) elevated blood pressure (BP) (1.47: 1.14–1.89). When analyzed on quartile 4 had 32% 63% higher prevalence BP, respectively, compared those 1 (P for trend: 0.021 < 0.001, respectively). Additionally, we identified 40% low HDL-C 2 (1.40; 1.07–1.83) trend = 0.454). In subgroup analysis, general obesity status modified abdominal obesity, showing positive obese individuals (1.72: 1.00-2.95) negative (0.80: 0.66–0.97) non-obese interaction 0.009). Higher scores an increased likelihood hyperglycemia, high BP among Longitudinal studies are needed determine causal relationships development potential role screening tool clinical practice.

Язык: Английский

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