Early pulmonary rehabilitation in ARDS patients: Effects on respiratory function and long-term outcomes: A retrospective study DOI Creative Commons

Li Da,

Kai Zhang

Medicine, Год журнала: 2024, Номер 103(51), С. e41023 - e41023

Опубликована: Дек. 20, 2024

This retrospective cohort study, conducted at People’s Hospital of Wenjiang Chengdu (January 2018 to January 2022), aimed evaluate the effects early pulmonary rehabilitation (PR) on respiratory function in acute distress syndrome patients after discontinuing invasive mechanical ventilation intensive care unit. Patients were divided into PR and control groups based an offline training protocol. Outcome measures included short physical performance battery scores, muscle strength, indicators discharge 3 months post-discharge, including peak expiratory flow, forced volume 1 second/forced vital capacity, capacity. Kaplan–Meier analysis assessed 6-month survival rates. Among 240 patients, 120 received traditional PR. Both had no significant differences baseline characteristics. Short scores strength showed gradual improvements both groups, with group achieving significantly higher 5 7 days ( P < .05). At such as capacity improved compared than those The number sputum aspirations decreased .05), unit stays weaning shorter revealed that cumulative rate 6 post-discharge was (hazard ratio = 0.660, 95% CI: 0.472–0.922, .014). These findings suggest enhances recovery, reduces complications, improves outcomes ventilation.

Язык: Английский

Network Toxicology and Molecular Docking Analysis of Tetracycline-Induced Acute Pancreatitis: Unveiling Core Mechanisms and Targets DOI Creative Commons
Hang Lei, Yan Wu, Wenjun Ma

и другие.

Toxics, Год журнала: 2024, Номер 12(12), С. 929 - 929

Опубликована: Дек. 21, 2024

Acute pancreatitis (AP), induced by tetracycline, a widely used antibiotic, poses significant clinical and toxicological challenges, yet its molecular mechanisms remain unclear. This study aims to promote drug toxicology strategies for the effective investigation of putative toxicity potential antibiotic drugs through tetracycline in AP. Using SwissTargetPrediction, SEA Search, Super-PRED, GeneCards, Drugbank, Online Mendelian Inheritance Man (OMIM), Therapeutic Target Database (TTD), we identified 259 targets associated with exposure Further refinement via STRING database Cytoscape (version 3.10.1) software highlighted 22 core targets, including TP53, TNF, AKT1. Functional enrichment Annotation, Visualization, Integrated Discovery (DAVID) pathways Gene Ontology (GO) terms Kyoto Encyclopedia Genes Genomes (KEGG) database, highlighting PI3K-Akt, MAPK, HIF-1, AGE-RAGE as critical mediators tetracycline-induced Molecular docking confirmed strong binding between targets. Overall, these findings suggest that may affect occurrence progression pancreas-related inflammation regulating pancreatic cell apoptosis proliferation, activating inflammatory signaling pathways, lipid metabolic pathways. provides theoretical basis understanding mechanism AP lays foundation prevention treatment digestive system diseases excessive antibiotics certain tetracyclines. In addition, our network approach has accelerated elucidation toxic lack specific characteristics.

Язык: Английский

Процитировано

1
Early pulmonary rehabilitation in ARDS patients: Effects on respiratory function and long-term outcomes: A retrospective study DOI Creative Commons

Li Da,

Kai Zhang

Medicine, Год журнала: 2024, Номер 103(51), С. e41023 - e41023

Опубликована: Дек. 20, 2024

This retrospective cohort study, conducted at People’s Hospital of Wenjiang Chengdu (January 2018 to January 2022), aimed evaluate the effects early pulmonary rehabilitation (PR) on respiratory function in acute distress syndrome patients after discontinuing invasive mechanical ventilation intensive care unit. Patients were divided into PR and control groups based an offline training protocol. Outcome measures included short physical performance battery scores, muscle strength, indicators discharge 3 months post-discharge, including peak expiratory flow, forced volume 1 second/forced vital capacity, capacity. Kaplan–Meier analysis assessed 6-month survival rates. Among 240 patients, 120 received traditional PR. Both had no significant differences baseline characteristics. Short scores strength showed gradual improvements both groups, with group achieving significantly higher 5 7 days ( P < .05). At such as capacity improved compared than those The number sputum aspirations decreased .05), unit stays weaning shorter revealed that cumulative rate 6 post-discharge was (hazard ratio = 0.660, 95% CI: 0.472–0.922, .014). These findings suggest enhances recovery, reduces complications, improves outcomes ventilation.

Язык: Английский

Процитировано

0