Nigella sativa: A Comprehensive Review of Its Therapeutic Potential, Pharmacological Properties, and Clinical Applications
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13410 - 13410
Опубликована: Дек. 14, 2024
Nigella
sativa
(NS)
is
an
annual
herb
belonging
to
the
Ranunculaceae
family,
also
known
as
black
cumin
or
seed.
This
plant
has
been
used
since
ancient
times
due
its
therapeutic
properties
and
proven
effective
in
gastrointestinal,
respiratory,
cardiovascular,
infectious,
inflammatory
conditions.
In
this
review,
aim
highlight
effects
of
Arab
countries
“the
that
cures
any
disease”,
which
are
provided
by
phytochemical
compounds
composition,
such
thymoquinone,
p-cymene,
α-thujene,
longifolene,
β-pinene,
α-pinene,
carvacrol.
These
confer
antioxidant
effect
seeds,
leading
a
significant
decrease
ROS
potent
anti-inflammatory
effect.
Also,
NS
seeds
may
have
synergistic
with
other
drugs,
chemotherapeutic
agents
antibiotics,
lead
reduction
dose,
improved
effect,
could
overcoming
obstacles
drug
resistance.
The
studies
review
showed
potential
be
agent
both
monotherapy
adjuvant.
Although
there
demonstrating
NS,
need
for
much
more
extensive
research
clinical
trials
clearly
established
objectives
so
mechanism
action
active
substances
better
understood.
With
data
far,
can
food
production
small
quantities
administered
short
periods.
Further
investigations
understanding
profile
most
mode
administration,
well
clearer
perspective
on
toxicological
NS.
Язык: Английский
The Astragalus Membranaceus Herb Attenuates Leukemia by Inhibiting the FLI1 Oncogene and Enhancing Anti-Tumor Immunity
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13426 - 13426
Опубликована: Дек. 14, 2024
Astragalus
membranaceus
(AM)
herb
is
a
component
of
traditional
Chinese
medicine
used
to
treat
various
cancers.
Herein,
we
demonstrate
strong
anti-leukemic
effect
AM
injected
(Ai)
into
the
mouse
model
erythroleukemia
induced
by
Friend
virus.
Chemical
analysis
combined
with
mass
spectrometry
AM/Ai
identified
compounds
Betulinic
acid,
Kaempferol,
Hederagenin,
and
formononetin,
all
major
mediators
leukemia
inhibition
in
culture
vivo.
Docking
demonstrated
binding
these
four
FLI1,
resulting
downregulation
its
targets,
induction
apoptosis,
differentiation,
suppression
cell
proliferation.
composition
other
previously
known
having
anti-tumor
activity
independent
FLI1
blockade.
Among
these,
Astragaloside-A
(As-A)
has
marginal
on
cells
culture,
but
strongly
inhibits
leukemogenesis
vivo,
likely
through
improvement
immunity.
Indeed,
both
IDO1
TDO2
were
as
targets
As-A,
leading
tryptophane-mediated
Kyn
production
suppression.
Moreover,
As-A
interacts
histamine
decarboxylase
(HDC),
anti-inflammatory
genes
TNF,
IL1B/IL1A,
TNFAIP3,
CXCR2,
not
IL6.
These
results
implicate
HDC
novel
immune
checkpoint
mediator,
tumor
microenvironment
promote
leukemia.
Functional
components
may
allow
development
combination
therapy
optimal
anti-leukemia
effect.
Язык: Английский