Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 2733 - 2746
Опубликована: Ноя. 1, 2024
Heat shock protein A4 (
Язык: Английский
Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 645 - 670
Опубликована: Янв. 1, 2025
Melanogenesis is a biochemical process that regulates skin pigmentation, which crucial role in protecting against ultraviolet radiation. It also associated with hyperpigmentation conditions such as melasma and age spots, negatively impact aesthetics self-confidence. Tyrosinase (TYR), key enzyme the melanogenesis pathway, catalyzes biosynthesis of melanin skin. Inhibition tyrosinase particularly by blocking its active site preventing binding natural substrates tyrosine, can reduce production, making it promising therapeutic target for treating hyperpigmentation. Peptides have emerged therapeutics to regulate minimizing side effects conventional whitening therapeutics. This review designed offer comprehensive analysis current strategies peptide design aimed at optimizing anti-melanogenic activity, focusing on molecular weight, polarity, cyclization enhancing efficacy stability. was found optimal size within range 400-600 Da. The balance between hydrophilic hydrophobic properties peptides effective TYR inhibition, higher hydrophilicity enhances affinity stronger catalytic while hydrophobicity contribute through alternative mechanisms. Cyclization their structural stability, serum resistance, reducing toxicity. increases resistance enzymatic degradation improves specificity limiting conformational flexibility. Additionally, rigidity internal hydrogen bonding cyclic aid membrane permeability, them more use. Peptide optimizations modification, polarity change, been shown be reliable safe agents inhibition. Future studies exploring specific amino acid chains are required improve potential clinical applications these treatment.
Язык: Английский
Процитировано
1
Environments, Год журнала: 2025, Номер 12(1), С. 13 - 13
Опубликована: Янв. 4, 2025
Given the persistently high incidence of skin cancer, there is a need for prevention-focused information on impact long-term changes in ambient solar ultraviolet radiation (UVR) human personal exposure. The exposure categories UV Index linked to protection recommendations show shifts frequency occurrence with regional differences direction and magnitude. patterns change sites humid continental climate differ from those other zones such as temperate or Mediterranean climate. diversity individual exposures indoor outdoor workers can be described using probability models erythema-effective UVR dose (UVD). For people who work indoors, largest share total annual UVD due vacation, whereas outdoors, it occupational UVDs at residential locations only partially reflected UVDs. eight selected European between 38° 60° northern latitude, median (excluding travel) during period 2009–2019 0.2 2.0% higher 0.6 3.2% compared 1983–2008. Changes choice an exemplary holiday destination offer both potential compensate observed trend their place residence work.
Язык: Английский
Процитировано
0
Journal of Inflammation Research, Год журнала: 2025, Номер Volume 18, С. 2531 - 2544
Опубликована: Фев. 1, 2025
Malignant melanoma (MM) is a highly aggressive cancer. Different subtypes have different sensitivities to immunotherapy and lack peripheral blood markers. Few studies examined the role of inflammatory markers in predicting overall survival (OS) stage IV acral (AM) cutaneous (CM) patients receiving immunotherapy. This study aimed investigate value efficacy prognosis for who underwent multicenter reviewed clinicopathological characteristics 94 AM CM PD-1 inhibitors therapy. Pearson's chi-squared test or Fisher's exact was used compare baseline characteristics. The optimal cut-off values these were stratified using time-dependent receiver operating characteristic curves (t-ROC). Kaplan-Meier (KM) Log rank explore relationship between outcomes. Cox regression analysis performed screen independent prognostic factors nomogram constructed. model ability tested by C-index, t-ROC, calibration curves, decision curve curves. High NLR level significantly correlated with lymph node metastasis 3 above metastatic sites (P=0.009, P=0.012). PNI favored better ECOG PS (P=0.023). According KM NLR>2.37, PNI<=42.65, RLR>11.08 had worse OS (P<0.001, P<0.001, P<0.001). based on P<0.05 showed that M1c/M1d (P<0.001), (P=0.003), (P<0.001) OS, visualized nomogram. area under (AUC), revealed promising discrimination accuracy Decision good clinical utility. We established predictive distant sites, NLR, PNI, verified its superior performance potential application.
Язык: Английский
Процитировано
0
ONCOLOGIE, Год журнала: 2024, Номер 26(5), С. 729 - 742
Опубликована: Авг. 19, 2024
Abstract Objectives Lipid metabolic dysregulation plays a critical role in the biological behavior of skin cutaneous melanoma (SKCM). Hence, we aimed to identify lipid metabolism-related genes (LMGs) and possible prognostic models for SKCM, perform risk assessment, predict effective therapies. Methods SKCM patient data were downloaded from The Cancer Genome Atlas (TCGA) used as training set; GSE65904 was validation dataset. A model established by multivariate Cox regression analysis LASSO algorithm. samples sets grouped into high- low-risk groups, respectively, accordance with model, score (RS) distribution survival ROC curve obtained. ‘limma’ package R3.6.1 Version 3.34.7 filter significant differentially expressed (DEGs) set between groups. For DEGs, functional enrichment immune infiltration analyses reveal potential disease mechanisms responses immunotherapy. expression level LMGs involved verified diverse methods. Results predictive comprising four LMGs, including ADH4, ALDH7A1, HADH, HADHA, survival. Functional has revealed enriched immune-associated pathways. Different microenvironments identified analysis. HPA immunohistochemical analysis, Real-time PCR Western blotting upregulation HADH HADHA downregulation ADH4 ALDH7A1 tissues or cell lines compared normal melanocyte cells. Conclusions may play behaviors therapeutic response melanoma. constructed serve prospective marker prognosis patients.
Язык: Английский
Процитировано
0
Diabetes Metabolic Syndrome and Obesity, Год журнала: 2024, Номер Volume 17, С. 3863 - 3873
Опубликована: Окт. 1, 2024
Obesity has been identified as a significant risk factor for various diseases, including certain cancers; however, its association with melanoma remains subject of debate. Despite the increasing incidence cutaneous in Taiwan, there limited research on correlation obesity. This study aims to investigate relationship between obesity and prognosis Taiwan.
Язык: Английский
Процитировано
0
OncoTargets and Therapy, Год журнала: 2024, Номер Volume 17, С. 871 - 886
Опубликована: Ноя. 1, 2024
Advanced malignant melanoma is a very aggressive disease, historically with poor prognosis before the new advances immunotherapy and targeted therapies that have changed standard of care, especially in cutaneous melanoma. Peru has features such as higher rates acral lentiginous (ALM) subtype shorter survival.
Язык: Английский
Процитировано
0
Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 2615 - 2625
Опубликована: Ноя. 1, 2024
Skin cutaneous melanoma (SKCM) ranks among the most prevalent malignant tumors, highlighting significance of identifying new research targets. In this study, our objective was to pinpoint pivotal genes implicated in SKCM pathogenesis and ascertain their potential as prognostic biomarkers.
Язык: Английский
Процитировано
0
Clinical Cosmetic and Investigational Dermatology, Год журнала: 2024, Номер Volume 17, С. 2733 - 2746
Опубликована: Ноя. 1, 2024
Heat shock protein A4 (
Язык: Английский
Процитировано
0