Design of Trabecular Bone Mimicking Voronoi Lattice-Based Scaffolds and CFD Modelling of Non-Newtonian Power Law Blood Flow Behaviour DOI Creative Commons
Haja-Sherief N Musthafa, Jason Walker

Computation, Год журнала: 2024, Номер 12(12), С. 241 - 241

Опубликована: Дек. 5, 2024

Designing scaffolds similar to the structure of trabecular bone requires specialised algorithms. Existing scaffold designs for tissue engineering have repeated patterns that do not replicate random stochastic porous internal architecture bones. In this research, Voronoi tessellation method is applied create biomimetic structures. A volume mesh created from shape a Zygoma fracture acts as boundary generation seed points by point spacing cells and diagrams. The lattices were obtained adding strut thickness Gradient pore sizes (19.8 µm 923 µm) designed. Finite Element Method-based computational fluid dynamics (CFD) simulation was performed on all designed predict pressure drops permeability non-Newtonian blood flow behaviour using power law material model. predicted (0.33 × 10−9 m2 2.17 m2) values CFD are comparable with specimens other research works.

Язык: Английский

Determining the optimal design parameters for gyroids using computational fluid dynamics analysis under a non-Newtonian perfusion system DOI Creative Commons

Abhisek Gupta,

Masud Rana,

Nitesh Mondal

и другие.

Biomedical Engineering Advances, Год журнала: 2025, Номер unknown, С. 100153 - 100153

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0

A review on Mg-based metallic glasses for biomedical scaffolds: experimental and computational modeling DOI Open Access
Chijioke Raphael Onyeagba, Tuquabo Tesfamichael

Microstructures, Год журнала: 2025, Номер 5(2)

Опубликована: Март 24, 2025

Magnesium (Mg)-based metallic glasses have emerged as a promising class of biomaterials for various biomedical applications due to their unique properties, such high strength-to-weight ratio, good biocompatibility and biodegradability. The development Mg-based glass scaffolds is particular interest tissue engineering regenerative medicine applications. However, the rate biodegradability materials not well controlled requires extensive research efficient tissue/bone regeneration. This review provides comprehensive overview recent advancements in tuneable with different compositions thin film coatings. It discusses structural biological mechanical biodegradation behavior, fabrication techniques employed produce bulk scaffolds. Furthermore, explores surface modification permanent implants biodegradable simulate regeneration on implants. Optimization scaffold design increase growth healing by understanding complex interactions between tissues predicting long-term implant behavior using computational models are reviewed. challenges future directions this field also discussed, providing insights into potential applications, including bone engineering, wound healing, cardiovascular

Язык: Английский

Процитировано

0

3D‐Printed Scaffolds for Cranial Bone Regeneration: A Systematic Review of Design, Materials, and Computational Optimization DOI

Elnaz Khorasani,

Bahman Vahidi

Biotechnology and Bioengineering, Год журнала: 2025, Номер unknown

Опубликована: Апрель 27, 2025

ABSTRACT Cranial bone defects from trauma, congenital conditions, or surgery are challenging to treat due the skull's limited regeneration. Traditional methods like autografts and allografts have drawbacks, including donor site issues poor integration. 3D‐printed scaffolds provide a patient‐specific alternative, improving regeneration This review evaluates advancements in for cranial regeneration, focusing on fabrication techniques, material innovations, structural optimization while assessing their preclinical clinical potential. A systematic literature search (2014–2024) was conducted using PubMed other databases. Studies addressing scaffold properties such as porosity, pore interconnectivity, mechanical stability were included, non‐cranial studies excluded. Advances 3D printing enabled with optimized architecture enhance support, nutrient transport. Bioceramics, polymers, composites mimic native properties, bioactive coatings further improve osteogenesis. However, translation insufficient customization remain challenges. Further trials crucial overcoming barriers fabrication, bridging gap between research applications.

Язык: Английский

Процитировано

0

BAYESIAN NEURAL NETWORKS FOR PROBABILISTIC MODELING OF THERMAL DYNAMICS IN MULTISCALE TISSUE ENGINEERING SCAFFOLDS DOI
Janjhyam Venkata Naga Ramesh, Abhilash Sonker, G. Indumathi

и другие.

Journal of Thermal Biology, Год журнала: 2025, Номер 130, С. 104134 - 104134

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Effects of mechanical stimuli on bone cells for regenerative medicine: a review of recent experimental and computational methods DOI Creative Commons

Emilie Wiedemann-Fodé,

Jessica Schiavi,

Halima Kerdjoudj

и другие.

Medical Engineering & Physics, Год журнала: 2025, Номер unknown, С. 104369 - 104369

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0

Transformative protein scaffold designs for dual-modality cancer applications: Advances in therapeutic delivery and molecular imaging of tumor microenvironments DOI
Mohammed Alissa,

Abdullah Alghamdi,

Suad A. Alghamdi

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 144881 - 144881

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0

A review of computational optimization of bone scaffold architecture: Methods, challenges, and perspectives DOI Creative Commons
Ali H. Foroughi,

Caleb Valeri,

Mir Jalil Razavi

и другие.

Progress in Biomedical Engineering, Год журнала: 2024, Номер 7(1), С. 012003 - 012003

Опубликована: Окт. 16, 2024

Abstract The design and optimization of bone scaffolds are critical for the success tissue engineering (BTE) applications. This review paper provides a comprehensive analysis computational methods scaffold architecture, focusing on balance between mechanical stability, biological compatibility, manufacturability. Finite element method (FEM), fluid dynamics (CFD), various algorithms discussed their roles in simulating refining designs. integration multiobjective topology has been highlighted developing that meet multifaceted requirements BTE. Challenges such as need consideration manufacturing constraints incorporation degradation regeneration models into process have identified. underscores potential advanced tools additive techniques evolving field BTE, aiming to improve patient outcomes regeneration. reliability current is examined, with suggestions incorporating non-deterministic approaches vivo validations enhance practical application optimized scaffolds. concludes call further research artificial intelligence-based advance optimization.

Язык: Английский

Процитировано

2

Determining the Permeability of Porous Bioceramic Scaffolds: Significance, Overview of Current Methods and Challenges Ahead DOI Open Access

Roberta Gabrieli,

Alessandro Schiavi, Francesco Baino

и другие.

Materials, Год журнала: 2024, Номер 17(22), С. 5522 - 5522

Опубликована: Ноя. 12, 2024

The “architectural suitability” of scaffolds for bone tissue engineering is commonly evaluated by assessing the pore volume and mean size (or distribution, if possible) comparing these values with reference ranges human cancellous bone. However, two parameters cannot precisely describe complex architecture just provide a preliminary comparative criterion. Permeability suggested as more comprehensive significant parameter to characterize scaffold mass transport capability, being also related in-growth and, thus, functional properties. permeability bioactive ceramics glass task from both methodological experimental viewpoints. After providing an overview fundamentals about porosity in scaffolds, this review explores different numerical approaches used determine porous bioceramics, describing methodologies (pump-based, gravity-based, acoustic computational methods) highlighting advantages limitations overcome (e.g., reliability issues need better standardization procedures).

Язык: Английский

Процитировано

1

Design of Trabecular Bone Mimicking Voronoi Lattice-Based Scaffolds and CFD Modelling of Non-Newtonian Power Law Blood Flow Behaviour DOI Creative Commons
Haja-Sherief N Musthafa, Jason Walker

Computation, Год журнала: 2024, Номер 12(12), С. 241 - 241

Опубликована: Дек. 5, 2024

Designing scaffolds similar to the structure of trabecular bone requires specialised algorithms. Existing scaffold designs for tissue engineering have repeated patterns that do not replicate random stochastic porous internal architecture bones. In this research, Voronoi tessellation method is applied create biomimetic structures. A volume mesh created from shape a Zygoma fracture acts as boundary generation seed points by point spacing cells and diagrams. The lattices were obtained adding strut thickness Gradient pore sizes (19.8 µm 923 µm) designed. Finite Element Method-based computational fluid dynamics (CFD) simulation was performed on all designed predict pressure drops permeability non-Newtonian blood flow behaviour using power law material model. predicted (0.33 × 10−9 m2 2.17 m2) values CFD are comparable with specimens other research works.

Язык: Английский

Процитировано

0