Determining the optimal design parameters for gyroids using computational fluid dynamics analysis under a non-Newtonian perfusion system
Biomedical Engineering Advances,
Год журнала:
2025,
Номер
unknown, С. 100153 - 100153
Опубликована: Март 1, 2025
Язык: Английский
A review on Mg-based metallic glasses for biomedical scaffolds: experimental and computational modeling
Microstructures,
Год журнала:
2025,
Номер
5(2)
Опубликована: Март 24, 2025
Magnesium
(Mg)-based
metallic
glasses
have
emerged
as
a
promising
class
of
biomaterials
for
various
biomedical
applications
due
to
their
unique
properties,
such
high
strength-to-weight
ratio,
good
biocompatibility
and
biodegradability.
The
development
Mg-based
glass
scaffolds
is
particular
interest
tissue
engineering
regenerative
medicine
applications.
However,
the
rate
biodegradability
materials
not
well
controlled
requires
extensive
research
efficient
tissue/bone
regeneration.
This
review
provides
comprehensive
overview
recent
advancements
in
tuneable
with
different
compositions
thin
film
coatings.
It
discusses
structural
biological
mechanical
biodegradation
behavior,
fabrication
techniques
employed
produce
bulk
scaffolds.
Furthermore,
explores
surface
modification
permanent
implants
biodegradable
simulate
regeneration
on
implants.
Optimization
scaffold
design
increase
growth
healing
by
understanding
complex
interactions
between
tissues
predicting
long-term
implant
behavior
using
computational
models
are
reviewed.
challenges
future
directions
this
field
also
discussed,
providing
insights
into
potential
applications,
including
bone
engineering,
wound
healing,
cardiovascular
Язык: Английский
3D‐Printed Scaffolds for Cranial Bone Regeneration: A Systematic Review of Design, Materials, and Computational Optimization
Biotechnology and Bioengineering,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
ABSTRACT
Cranial
bone
defects
from
trauma,
congenital
conditions,
or
surgery
are
challenging
to
treat
due
the
skull's
limited
regeneration.
Traditional
methods
like
autografts
and
allografts
have
drawbacks,
including
donor
site
issues
poor
integration.
3D‐printed
scaffolds
provide
a
patient‐specific
alternative,
improving
regeneration
This
review
evaluates
advancements
in
for
cranial
regeneration,
focusing
on
fabrication
techniques,
material
innovations,
structural
optimization
while
assessing
their
preclinical
clinical
potential.
A
systematic
literature
search
(2014–2024)
was
conducted
using
PubMed
other
databases.
Studies
addressing
scaffold
properties
such
as
porosity,
pore
interconnectivity,
mechanical
stability
were
included,
non‐cranial
studies
excluded.
Advances
3D
printing
enabled
with
optimized
architecture
enhance
support,
nutrient
transport.
Bioceramics,
polymers,
composites
mimic
native
properties,
bioactive
coatings
further
improve
osteogenesis.
However,
translation
insufficient
customization
remain
challenges.
Further
trials
crucial
overcoming
barriers
fabrication,
bridging
gap
between
research
applications.
Язык: Английский
BAYESIAN NEURAL NETWORKS FOR PROBABILISTIC MODELING OF THERMAL DYNAMICS IN MULTISCALE TISSUE ENGINEERING SCAFFOLDS
Journal of Thermal Biology,
Год журнала:
2025,
Номер
130, С. 104134 - 104134
Опубликована: Май 1, 2025
Язык: Английский
Effects of mechanical stimuli on bone cells for regenerative medicine: a review of recent experimental and computational methods
Medical Engineering & Physics,
Год журнала:
2025,
Номер
unknown, С. 104369 - 104369
Опубликована: Май 1, 2025
Язык: Английский
Transformative protein scaffold designs for dual-modality cancer applications: Advances in therapeutic delivery and molecular imaging of tumor microenvironments
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 144881 - 144881
Опубликована: Июнь 1, 2025
Язык: Английский
A review of computational optimization of bone scaffold architecture: Methods, challenges, and perspectives
Progress in Biomedical Engineering,
Год журнала:
2024,
Номер
7(1), С. 012003 - 012003
Опубликована: Окт. 16, 2024
Abstract
The
design
and
optimization
of
bone
scaffolds
are
critical
for
the
success
tissue
engineering
(BTE)
applications.
This
review
paper
provides
a
comprehensive
analysis
computational
methods
scaffold
architecture,
focusing
on
balance
between
mechanical
stability,
biological
compatibility,
manufacturability.
Finite
element
method
(FEM),
fluid
dynamics
(CFD),
various
algorithms
discussed
their
roles
in
simulating
refining
designs.
integration
multiobjective
topology
has
been
highlighted
developing
that
meet
multifaceted
requirements
BTE.
Challenges
such
as
need
consideration
manufacturing
constraints
incorporation
degradation
regeneration
models
into
process
have
identified.
underscores
potential
advanced
tools
additive
techniques
evolving
field
BTE,
aiming
to
improve
patient
outcomes
regeneration.
reliability
current
is
examined,
with
suggestions
incorporating
non-deterministic
approaches
vivo
validations
enhance
practical
application
optimized
scaffolds.
concludes
call
further
research
artificial
intelligence-based
advance
optimization.
Язык: Английский
Determining the Permeability of Porous Bioceramic Scaffolds: Significance, Overview of Current Methods and Challenges Ahead
Materials,
Год журнала:
2024,
Номер
17(22), С. 5522 - 5522
Опубликована: Ноя. 12, 2024
The
“architectural
suitability”
of
scaffolds
for
bone
tissue
engineering
is
commonly
evaluated
by
assessing
the
pore
volume
and
mean
size
(or
distribution,
if
possible)
comparing
these
values
with
reference
ranges
human
cancellous
bone.
However,
two
parameters
cannot
precisely
describe
complex
architecture
just
provide
a
preliminary
comparative
criterion.
Permeability
suggested
as
more
comprehensive
significant
parameter
to
characterize
scaffold
mass
transport
capability,
being
also
related
in-growth
and,
thus,
functional
properties.
permeability
bioactive
ceramics
glass
task
from
both
methodological
experimental
viewpoints.
After
providing
an
overview
fundamentals
about
porosity
in
scaffolds,
this
review
explores
different
numerical
approaches
used
determine
porous
bioceramics,
describing
methodologies
(pump-based,
gravity-based,
acoustic
computational
methods)
highlighting
advantages
limitations
overcome
(e.g.,
reliability
issues
need
better
standardization
procedures).
Язык: Английский
Design of Trabecular Bone Mimicking Voronoi Lattice-Based Scaffolds and CFD Modelling of Non-Newtonian Power Law Blood Flow Behaviour
Computation,
Год журнала:
2024,
Номер
12(12), С. 241 - 241
Опубликована: Дек. 5, 2024
Designing
scaffolds
similar
to
the
structure
of
trabecular
bone
requires
specialised
algorithms.
Existing
scaffold
designs
for
tissue
engineering
have
repeated
patterns
that
do
not
replicate
random
stochastic
porous
internal
architecture
bones.
In
this
research,
Voronoi
tessellation
method
is
applied
create
biomimetic
structures.
A
volume
mesh
created
from
shape
a
Zygoma
fracture
acts
as
boundary
generation
seed
points
by
point
spacing
cells
and
diagrams.
The
lattices
were
obtained
adding
strut
thickness
Gradient
pore
sizes
(19.8
µm
923
µm)
designed.
Finite
Element
Method-based
computational
fluid
dynamics
(CFD)
simulation
was
performed
on
all
designed
predict
pressure
drops
permeability
non-Newtonian
blood
flow
behaviour
using
power
law
material
model.
predicted
(0.33
×
10−9
m2
2.17
m2)
values
CFD
are
comparable
with
specimens
other
research
works.
Язык: Английский