SARS-CoV-2 Evolution: Implications for Diagnosis, Treatment, Vaccine Effectiveness and Development

Vaccines, Год журнала: 2024, Номер 13(1), С. 17 - 17

Опубликована: Дек. 28, 2024

The COVID-19 pandemic, driven by the rapid evolution of SARS-CoV-2 virus, presents ongoing challenges to global public health. is characterized rapidly evolving mutations, especially in (but not limited to) spike protein, complicating predictions about its evolutionary trajectory. These mutations have significantly affected transmissibility, immune evasion, and vaccine efficacy, leading multiple pandemic waves with over half a billion cases seven million deaths globally. Despite several strategies, from development administration design availability antivirals, including monoclonal antibodies, already having been employed, persistent circulation virus emergence new variants continue result high case numbers fatalities. In past four years, immense research efforts contributed much our understanding viral pathogenesis mechanism, syndrome, host-microbe interactions, effective vaccines, diagnostic tools, treatments. focus this review provide comprehensive analysis functional impact on diagnosis, treatments, effectiveness. We further discuss safety pregnancy implications hybrid immunity long-term protection against infection, as well latest developments pan-coronavirus nasal formulations, emphasizing need for continued surveillance, research, adaptive health strategies response race.

Язык: Английский

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The Eye of the Storm: Investigating the Long-Term Cardiovascular Effects of COVID-19 and Variants

Cells, Год журнала: 2023, Номер 12(17), С. 2154 - 2154

Опубликована: Авг. 27, 2023

COVID-19 had stormed through the world in early March of 2019, and on 5 May 2023, SARS-CoV-2 was officially declared to no longer be a global health emergency. The rise new variants XBB.1.5 XBB.1.16, product recombinant sub-strains, has fueled need for continued surveillance pandemic as they have been deemed increasingly infectious. Regardless severity variant, this caused an increase hospitalizations, strain resources, concern public health. In addition, there is growing population patients experiencing cardiovascular complications result post-acute sequelae COVID-19. This review aims focus what known about its past (Alpha, Delta, Omicron) how knowledge grown today with emerging variants, emphasis complexities. We possible mechanisms that cause observations chronic cardiac conditions seen even after recovered from infection. Further understanding these will help close gap differences between effects variants.

Язык: Английский

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Impact of Prenatal COVID-19 Infection on Maternal and Child Health: Early Insights from the PREGCOVID Longitudinal Cohort Study in Gujarat, India

Опубликована: Янв. 1, 2024

Язык: Английский

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Prenatal COVID-19 Infection and Perinatal Outcomes: Findings from PREGCOVID Longitudinal Cohort Study in Gujarat, India

Опубликована: Янв. 1, 2024

Язык: Английский

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