Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management DOI Creative Commons
Dina Louis,

Christianne Mounir Zaki Rizkalla,

Amira Rashad

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 6173 - 6184

Опубликована: Дек. 1, 2024

Nitrofurantoin (NITRO), a long-standing antibiotic to treat urinary tract infections, is activated by Nitro reductases. This activation mechanism has led its exploration for repositioning applications in controlling and treating breast cancer, which express reductase gene.

Язык: Английский

Novel Oxaprozin Cocrystals/Salts: Solubility Enhancement for Oxaprozin and Release Control for Minoxidil DOI

Lingli Hou,

Menglong Zhang,

Linlin Shi

и другие.

Crystal Growth & Design, Год журнала: 2025, Номер unknown

Опубликована: Апрель 9, 2025

Язык: Английский

Процитировано

0
Flavone Cocrystals: A Comprehensive Approach Integrating Experimental and Virtual Methods DOI Creative Commons

Tom L. Petrick,

Alexandra Grünwald,

Doris E. Braun

и другие.

Crystal Growth & Design, Год журнала: 2024, Номер 24(10), С. 4195 - 4212

Опубликована: Май 6, 2024

The dapsone/flavone cocrystal system served as a benchmark for both experimental and virtual screening methods. Expanding beyond this, two additional active pharmaceutical ingredients (APIs), sulfanilamide sulfaguanidine, structurally related to dapsone were chosen investigate the impact of substituents on formation. involved mechanochemical methods, slurry experiments, hot-melt extrusion, contact preparation method. focused crystal structure prediction (CSP), molecular complementarity, hydrogen-bond propensity, electrostatic potentials. CSP studies not only indicated that each three APIs should form cocrystals with flavone but also reproduced known single- multicomponent phases. Experimentally, ACC, BCC, CCC, DCC reproduced, CCC was identified nonstoichiometric hydrate, fifth (ECC), t-butanol solvate, discovered. polymorphs ACC BCC are enantiotripically related, DCC, exhibiting different stoichiometric ratio, is enthalpically stabilized over other cocrystals. For sulfaguanidine/flavone system, novel, identified. structures polymorph solved from powder X-ray diffraction data, stability all assessed through differential scanning calorimetry lattice energy calculations. Despite computational indications, diverse array cocrystallization techniques did result in sulfanilamide/flavone cocrystal. driving force behind dapsone's tendency cocrystallize can be attributed overall strength interactions potential strong API···API API···coformer contributing factor. Furthermore, found trimorphic.

Язык: Английский

Процитировано

3
A Comprehensive Review on Theoretical Screening Methods for Pharmaceutical Cocrystals DOI

J. Roshni,

T. Karthick

Journal of Molecular Structure, Год журнала: 2024, Номер 1321, С. 139868 - 139868

Опубликована: Сен. 1, 2024

Язык: Английский

Процитировано

2
Pyridine derivatives sublimation processes: Fundamental aspects and application for two-component crystals screening DOI
Alexander P. Voronin, О. Р. Симонова, Тatyana V. Volkova

и другие.

Physical Chemistry Chemical Physics, Год журнала: 2024, Номер 26(34), С. 22558 - 22571

Опубликована: Янв. 1, 2024

The saturated vapour pressures of five heterocyclic compounds containing the pyridine fragment, namely, three isomers aminopyridine (2-aminopyridine (2AmPy), 3-aminopyridine (3AmPy), and 4-aminopyridine (4AmPy)); 3-hydroxypyridine (3OHPy) 2-(1

Язык: Английский

Процитировано

1
Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management DOI Creative Commons
Dina Louis,

Christianne Mounir Zaki Rizkalla,

Amira Rashad

и другие.

Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 6173 - 6184

Опубликована: Дек. 1, 2024

Nitrofurantoin (NITRO), a long-standing antibiotic to treat urinary tract infections, is activated by Nitro reductases. This activation mechanism has led its exploration for repositioning applications in controlling and treating breast cancer, which express reductase gene.

Язык: Английский

Процитировано

0