Visual Mapping and Future Direction of Marine Products Supplementary and Chemotherapy in The Treatment of Breast Cancer. A Bibliometric

Pharmacognosy Journal, Год журнала: 2025, Номер 16(6), С. 1379 - 1388

Опубликована: Янв. 1, 2025

Marine products have gained attention for their potential benefits in the treatment of breast cancer, offering an alternative or supplementary approach to traditional therapies. While they are not intended replace established medical treatments like chemotherapy surgery, marine natural shown promise providing symptom relief, enhancing quality life, and potentially improving success cancer patients. Studies explored use conjunction with palliative care as adjuvants conventional Marinederived compounds been investigated anticancer properties, including apoptosis induction, anti-proliferative effects, modulation signaling pathways involved progression. These offer a complementary avenue managing outcomes, addressing therapeutic challenges. The utilization therapy dates back ancient times when various cultures recognized plants, herbs, resources. purpose this study is visually map guide future research on based bibliometric analysis

Язык: Английский

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Marine actinobacteria metabolites: unlocking new treatments for acne vulgaris

Frontiers in Microbiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 6, 2025

Marine-derived actinobacteria isolated from sponge Cliona varians and soft coral Eunicea fusca were screened for antibacterial activity against acne-related bacteria, specifically Staphylococcus epidermidis ATCC 14990, methicillin-resistant aureus BAA44, Cutibacterium acnes 6919. Cytotoxicity assays performed on human dermal fibroblast (HDFa) keratinocyte (HaCaT) cell lines to assess the safety profile of extracts. Chemical characterization was conducted using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). Among extracts, six derived Kocuria sp., Rhodococcus Nocardia Micrococcus Streptomyces sp. demonstrated significant activity. Notably, extract Z9.216 exhibited highest efficacy, inhibiting S. by 68%, 93%, C. 98.7% at a concentration 0.003 mg/mL, which comparable standard antibiotics erythromycin vancomycin, while maintaining over 90% viability in both HDFa HaCaT lines. Untargeted metabolomic analysis suggested that might be associated compounds chemical families alkaloids, terpenoids, fatty acids, among others. These findings highlight therapeutic potential marine underexplored environments as promising strategy treating acne vulgaris, chronic inflammatory skin condition.

Язык: Английский

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Bacteria Associated with Marine Benthic Invertebrates from Polar Environments: Unexplored Frontiers for Biodiscovery?

Diversity, Год журнала: 2018, Номер 10(3), С. 80 - 80

Опубликована: Авг. 2, 2018

The ecological function of bacteria-invertebrate interactions in Polar areas remains poorly understood, despite increasing evidence that microbial metabolites may play pivotal roles host-associated chemical defense and shaping the symbiotic community structure. metabolic physiological changes these organisms undergo response to adapting extreme conditions result production structurally functionally novel biologically active molecules. Deepening our knowledge on between bacteria their invertebrate host would be highly helpful providing rationale for why (e.g., competition or cooperative purpose) which (whether secondary metabolites, enzymes, proteins) bioactive compounds are produced. To date, cold-adapted associated with marine invertebrates from Arctic Antarctica have not been given attention they deserve versatility natural products virtually unexplored, even if could represent a new attractive frontier search compounds. This review is aimed at showcasing diversity benthic areas, highlighting yet unexplored treasure biodiscovery.

Язык: Английский

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Role of symbiosis in the discovery of novel antibiotics

The Journal of Antibiotics, Год журнала: 2020, Номер 73(8), С. 490 - 503

Опубликована: Июнь 4, 2020

Язык: Английский

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Two new aromatic polyketides from a sponge-derived Fusarium

Beilstein Journal of Organic Chemistry, Год журнала: 2019, Номер 15, С. 2941 - 2947

Опубликована: Дек. 9, 2019

In our natural product screening program from marine fungi, two new aromatic polyketides karimunones A ( 1 ) and B 2 five known compounds 3 – 7 were isolated sponge-associated Fusarium sp. KJMT.FP.4.3 which was collected an Indonesian sponge Xestospongia The structures of these determined by the analysis NMR MS spectroscopic data. assignment assisted DFT-based theoretical chemical shift calculation. Compound showed antibacterial activity against multidrug resistant Salmonella enterica ser. Typhi with a MIC 125 µg/mL while not active.

Язык: Английский

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The natural product biosynthetic potential of Red Sea nudibranch microbiomes

PeerJ, Год журнала: 2021, Номер 9, С. e10525 - e10525

Опубликована: Фев. 4, 2021

Antibiotic resistance is a growing problem that can be ameliorated by the discovery of novel drug candidates. Bacterial associates are often source pharmaceutically active natural products isolated from marine invertebrates, and thus, important targets for discovery. While microbiomes many organisms have been extensively studied, microbial communities chemically-rich nudibranchs, invertebrates possess chemical defences, relatively unknown.We applied both culture-dependent independent approaches to better understand biochemical potential associated with nudibranchs. Gram-positive microorganisms nudibranchs collected in Red Sea were screened antibacterial antitumor activity. To assess their potential, isolates presence product biosynthetic gene clusters, including polyketide synthase (PKS) non-ribosomal peptide synthetase (NRPS) genes, using PCR. The investigated high-throughput sequencing 16S rRNA amplicons.In screens against five model microorganisms, 51% extracts displayed antimicrobial activity more than one organism, 19% exhibited Ehrlich's ascites carcinoma. Sixty-four percent contained PKS NRPS suggesting genomes contain clusters biosynthesis. Thirty-five positive class gene. These strains identified as belonging Firmicutes Actinobacteria phyla via sequencing. In addition, community amplicon revealed all bacterial present uncultured host-associated microbiome, although they very small percentage total community. Taken together, these results indicate bacteria potentially rich bioactive compounds genes.

Язык: Английский

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Testacosides A–D, glycoglycerolipids produced by Microbacterium testaceum isolated from Tedania brasiliensis

Applied Microbiology and Biotechnology, Год журнала: 2024, Номер 108(1)

Опубликована: Янв. 12, 2024

Marine bacteria living in association with marine sponges have proven to be a reliable source of biologically active secondary metabolites. However, no studies yet reported natural products from Microbacterium testaceum spp. We herein report the isolation M. strain sponge Tedania brasiliensis. Molecular networking analysis bioactive pre-fractionated extracts culture media enabled discovery testacosides A-D. Analysis spectroscopic data and chemical derivatizations allowed identification A-D as glycoglycerolipids bearing 1-[α-glucopyranosyl-(1 → 3)-(α-mannopyranosyl)]-glycerol moiety connected 12-methyltetradecanoic acid for testacoside A (1), 14-methylpentadecanoic B (2), 14-methylhexadecanoic C (3) D (4). The absolute configuration monosaccharide residues was determined by

Язык: Английский

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Combating Parasitic Nematode Infections, Newly Discovered Antinematode Compounds from Marine Epiphytic Bacteria

Microorganisms, Год журнала: 2020, Номер 8(12), С. 1963 - 1963

Опубликована: Дек. 11, 2020

Parasitic nematode infections cause debilitating diseases and impede economic productivity. Antinematode chemotherapies are fundamental to modern medicine also important for industries including agriculture, aquaculture animal health. However, the lack of suitable treatments some rise resistance many available therapies necessitates discovery development new drugs. Here, marine epiphytic bacteria represent a promising repository newly discovered antinematode compounds. Epiphytic ubiquitous on surfaces where they under constant pressure grazing by bacterivorous predators (e.g., protozoans nematodes). Studies have shown that these developed defense strategies prevent grazers producing toxic bioactive Although several active metabolites against nematodes been identified from bacteria, drug microorganisms remains underexplored. In this review, we aim provide further insight into need potential become source We discuss current emerging strategies, culture-independent high throughput screening utilization Caenorhabditis elegans as model target organism, which will be required advance microbial sources.

Язык: Английский

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Evaluation of the Effects of Library Preparation Procedure and Sample Characteristics on the Accuracy of Metagenomic Profiles

mSystems, Год журнала: 2021, Номер 6(5)

Опубликована: Окт. 12, 2021

Metagenomic library preparation methods and sequencing technologies continue to advance rapidly, allowing researchers characterize microbial communities in previously underexplored environmental samples systems. However, widely accepted standardized can be cost-prohibitive.

Язык: Английский

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Exploring the Diversity and Antibacterial Potentiality of Cultivable Actinobacteria from the Soil of the Saxaul Forest in Southern Gobi Desert in Mongolia

Microorganisms, Год журнала: 2022, Номер 10(5), С. 989 - 989

Опубликована: Май 9, 2022

Saxaul (Haloxylon ammodendron) is the most widespread plant community in Gobi Desert Mongolia, which plays important roles wind control, sand fixation and water conservation. Investigations of soil-derived actinobacteria inhabiting saxaul forest Mongolia have been scarce. In this study, biodiversity culturable isolated from soil Southern Aimak (Southern Province) was characterized their potential to produce compounds with antibacterial activities assessed. A total 172 actinobacterial strains were recovered by culture-based approaches phylogenetically affiliated into 22 genera 13 families seven orders. Forty-nine isolates selected evaluate underlying mechanism action screened means a dual-fluorescent reporter assay (pDualrep2). Twenty-three exhibited antagonistic activity against at least one tested pathogens, two Streptomyces can attenuate protein translation ribosome stalling. Combinational strategies based on modern metabolomics, including bioassay-guided thin-layer chromatography (TLC), UPLC-QTOF-MS/MS structural annotation enhanced molecular networking successfully annotated chloramphenicol, althiomycin granaticin derivatives as extracts three strains, respectively. This work demonstrates that UPLC-MS/MS-based identification are effective rapidly illuminate bioactive chemicals microbial extracts. Meanwhile, our results show prospective source for discovering novel biologically active compounds.

Язык: Английский

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