Inflammatory markers and physical frailty: towards clinical application

Immunity & Ageing, Год журнала: 2024, Номер 21(1)

Опубликована: Янв. 6, 2024

Abstract Global population aging poses a tremendous burden on the health care system worldwide. Frailty is associated with decreased physical reserve and considered an important indicator of adverse events in older population. Therefore, there growing interest early diagnosis intervention frailty, but cellular mechanisms responsible for frailty are still not completely understood. Chronic inflammation related to function increased disease risk. Additionally, multiple human animal studies suggest that probably plays largest role contributing frailty. Some inflammatory markers have been proposed predict However, large gaps knowledge clinical application these frail patients. understanding biological processes identifying recognized reliable urgent pivotal tasks geriatricians. In present review, we broadly summarize may potential diagnostic therapeutic use, thereby translating them into people near future.

Язык: Английский

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Proteomics for the Discovery of Clinical Delirium Biomarkers: A Systematic Review of Major Studies

Anesthesia & Analgesia, Год журнала: 2022, Номер unknown

Опубликована: Дек. 29, 2022

Delirium represents a significant health care burden, diagnosed in more than 2 million elderly Americans each year. In the surgical population, delirium remains most common complication among patients, and is associated with longer hospital stays, higher costs of care, increased mortality, functional impairment. The pathomechanism disease poorly understood, current diagnostic approaches somewhat subjective arbitrary, definitive biomarkers are currently lacking. Despite recent interest research, biomarker discovery for it new. Most attempts to discover targeted studies that seek assess involvement one or members focused panel candidates delirium. For unbiased, system-biology view, we searched literature from Medical Literature Analysis Retrieval System Online (MEDLINE), Cochrane Central, Web Science, SCOPUS, Dimensions between 2016 2021 untargeted proteomic conducted on human geriatric subjects. Two reviewers an independent review all search results resolved discordance by consensus. From overall 1172 publications, 8 peer-reviewed met our defined inclusion criteria. 370 unique perioperative identified these reports enriched pathways involving activation immune system, inflammatory response, coagulation cascade. frequently was interleukin-6 (IL-6). By reviewing distribution protein studies, conclude proteins, rather single biomarker, would allow discriminating cases noncases. paucity hypothesis-generating also suggests view pathomechanisms has yet fully emerge.

Язык: Английский

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Aging‐Related CYP3A Functional Changes in the Chinese Older Patients: New Findings from Model‐Based Assessment of Amlodipine

Clinical Pharmacology & Therapeutics, Год журнала: 2024, Номер 116(3), С. 858 - 865

Опубликована: Июнь 22, 2024

Aging‐related alterations in hepatic enzyme activity, particularly of the CYP3A, significantly impact drug efficacy and safety older adults, making it essential to understand how aging affects CYP function for optimal therapy. The exogenous probe substrate method, a minimally invasive approach assess liver metabolic activity vivo , is effective studying these changes. Amlodipine being extensively metabolized (> 90%) liver, primarily via cytochrome P450 CYP3A was selected as investigate quantify factors affecting aging‐related changes Chinese population. concentration data were collected from an ongoing noninterventional clinical study conducted at Peking University Third Hospital. A physiologically‐based pharmacokinetic modeling approach, grounded population (PPK) analysis, employed physiologically function. total 132 amlodipine concentrations 69 patients obtained study. PPK analysis shows that frailty phenotype but not age significant influence frail have 37% greater plasma exposure than nonfrail patients. This difference may be attributed 63.2% lower relative abundance patients, compared with In context dose selection focusing on rather chronological should recognized more relevant because might accurately reflect individual's biological age. Our suggested need shift research focus

Язык: Английский

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Building Research Infrastructure to Address Psychosocial Frailty and Reach Underserved Aging Populations

Journal of Psychosocial Nursing and Mental Health Services, Год журнала: 2025, Номер 63(2), С. 7 - 10

Опубликована: Фев. 1, 2025

Frailty is prevalent in adults aged ≥50 years, particularly among under-served minorities. a multidimensional concept including physical, psychological, and social frailty, any definition of frailty should meet the criterion practicality that could be measurable, preventable, or modified by interventions clinically reasonable. Early detection tailored can delay progression prevent adverse health outcomes. However, there limited recruitment underserved minorities lack research on early embedded adaptive systems adequately needs aging populations. Nursing scientists, public professionals, policymakers aware each dimension while addressing creating substantial infrastructure development to reaches populations rural, suburban, urban areas benefits larger community. [ Journal Psychosocial Mental Services, 63 (2), 7–10.]

Язык: Английский

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Propensity Score Matching Analysis on Risk Factors and Their Diagnostic Value of Frailty in Elderly Patients With Cerebral Infarction

The Neurologist, Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

Objectives: Cerebral infarction is an acute ischemic cerebrovascular disease; elderly patients with cerebral often have frailty syndrome. Therefore, the aim of this study was to analyze risk factors and their diagnostic value in infarction. Methods: In retrospective cohort study, medical records (from October 2017 September 2020) (n=395) were analyzed. According different statuses, divided into health group (n=166) prefrailty (n=229). The various parameters for occurrence pre-frailty assessed by receiver operating characteristic (ROC) curve area under ROC (AUC). analyzed single-factor multi-factor analyses. Results: Interleukin-6 (IL-6, P <0.001), C-reactive protein (CRP), prealbumin (PA, albumin (ALB, brain natriuretic peptide (BNP, <0.001) had higher Single-factor analysis results revealed that length stay (LOS), comorbidity nervous system diseases, high Charlson index (CCI), National Institute Health stroke scale score, IL-6, BNP, ALB, PA, creatine kinase might ( <0.05). After elimination interference factors, LOS, CCI, ALB confirmed be key Conclusion: are underlying infarction, which provides a theoretical basis clinical disease diagnosis.

Язык: Английский

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Proteomics for the discovery of clinical delirium biomarkers: A systematic review of Major Studies

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Июнь 8, 2022

Abstract Delirium represents a significant healthcare burden, diagnosed in over two million elderly Americans each year. In the surgical population, delirium remains most common complication among patients and is associated with longer hospital stays, higher costs of care, increased mortality functional impairment. The pathomechanism disease poorly understood, current diagnostic approaches somewhat subjective arbitrary, definitive biomarkers are currently lacking. Despite recent interest research, biomarker discovery for it new. Most attempts to discover targeted studies that seek assess involvement one or more members focused panel candidates delirium. For unbiased, systems-biology view, we searched literature from MEDLINE, Cochrane Central, Web Science, SCOPUS, Dimensions between 2016 2021 untargeted proteomic conducted on human geriatric subjects. Two reviewers independent review all search results, resolved discordance by concensus. From an overall 1172 publications, eight peer-reviewed met our defined inclusion criteria. 370 unique peri-operative identified these reports enriched pathways involving activation immune system, inflammatory response, coagulation cascade. IL-6 was commonly biomarker. By reviewing distribution protein studies, conclude proteins, rather than single biomarker, would allow discriminating cases non-cases. paucity hypothesis-generating also suggests view pathomechanisms has yet fully emerge.

Язык: Английский

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Translational research into frailty from bench to bedside: Salivary biomarkers for inflammaging

Experimental Gerontology, Год журнала: 2022, Номер 171, С. 112040 - 112040

Опубликована: Ноя. 28, 2022

Frailty is a complex physiological syndrome associated with adverse ageing and decreased reserves. leads to cognitive physical disability significant cause of morbidity, mortality economic costs. The underlying frailty multifaceted, including immunosenescence inflammaging, changes in microbiota metabolic dysfunction. Currently, salivary biomarkers are used as early predictors for some clinical diseases, contributing the effective prevention treatment frailty. Sample collection analysis non-invasive simple, which paramount factors testing vulnerable frail population. aim this review describe current knowledge on association between inflammatory process discuss methods identify putative fluids predict syndrome. This study describes relationship i.-inflammatory frailty; ii.-infectious, chronic, skeletal, diseases inflammation iii.-inflammatory fluids. There limited number previous studies focusing syndrome; hence, source an open area research potential address increasing demands frailty-associated biomarkers.

Язык: Английский

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Relationship between prevalence of cardiometabolic diseases, self-reported memory loss, and self-reported depressed mood of older adults in Korea according to frailty and physical activity status

Journal of Men s Health, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

As the older population increases worldwide, frailty is area of research that deserve further investigation and considered a major social public health concern. Frailty appears physically mentally, recently, term cognitive has been used to combine physical mild impairment syndrome. in adults characterized by low activity levels sedentary lifestyle. Physical essential managing mental issues such as depression can improve executive function memory with impairment. Therefore, this study aimed examine prevalence cardiometabolic diseases, self-reported loss, among Korea according status. Using data from 2019 National Health Nutrition Survey, analyzed 613 community-dwelling males aged ≥65 years. was measured using Global Activity Questionnaire. A health-related quality life instrument eight items (HINT-8) assess loss depressed mood. Relationships between levels, mood were logistic regression. The incidence HINT-8 (0.52 (95% confidence interval (CI): 0.32–0.85)) significantly lower Level (PAL)-high/pre-frail; (0.35 CI: 0.21–0.59); 0.29 0.17–0.52)) PAL-high/pre-frail. We verified group PAL-low/frail had highest mood, suggesting more may reduce frail Korea. However needed analyze level separately work leisure.

Язык: Английский

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Potential Protein Biomarkers in Saliva for Detection of Frailty Syndrome by targeted proteomics

Mechanisms of Ageing and Development, Год журнала: 2024, Номер 221, С. 111974 - 111974

Опубликована: Июль 20, 2024

Язык: Английский

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Depression and Plasma pTau₁₈₁ Levels Are Associated with Frailty Status in Hispanic Community-Dwelling Older Women

Gerontology and Geriatric Medicine, Год журнала: 2024, Номер 10

Опубликована: Янв. 1, 2024

The population of Hispanic older adults is growing along with the burden chronic diseases. This cross-sectional study aims to assess factors associated frailty among community-dwelling women aged ≥60 years ( n = 357) enrolled in Panama Aging Research Initiative—Health Disparities cognitive-functional health persons Panama. Cognitive function was assessed a neuropsychological test battery. Depression measured Geriatric Scale. Frailty defined using Fried criteria and participants were classified as non-frail, pre-frail or frail. A subsample 281) provided fasting blood samples for quantification protein biomarkers. Associations examined hierarchical multiple linear regressions. 59.4% 9.0% M 69.2 years, SD 6.3) frail, respectively. Having more depression (β .28, p < .001) significantly frailty, even after covariate adjustment. not frailty. Higher pTau181 levels increased .13, .039), whereas higher α2M decreased −.16, .004). These findings advance search indicators biomarkers warrant further studies decrease women.

Язык: Английский

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