Turkish Journal of Pediatric Disease,
Год журнала:
2023,
Номер
unknown, С. 1 - 7
Опубликована: Апрель 25, 2023
Background:
The
aim
of
this
study
was
to
determine
the
reasons
for
request
antinuclear
antibody
(ANA)
in
ANA-positive
patients
and
final
diagnosis
these
whether
they
developed
a
rheumatologic
disease.
Method:
In
retrospective
study,
files
559
with
positive
ANA
were
reviewed.
Demographic,
laboratory
clinical
characteristics
noted.
At
end
follow-up,
recorded.
Results:
included
346
patients.
233
female,
113
male.
mean
age
at
time
positivity
9.4
4.7
years,
follow-up
period
19
5.7
months.
most
common
symptom
myalgia/arthralgia
(21.7%).
Other
urticaria,
abdominal
pain,
thrombocytopenia,
proteinuria.
Extractable
nuclear
antigens
(ENA)
panel
results
negative
170
(49.1%).
ENA
panel,
dense
fine
speckled
antigen
70
antibodies
frequently
135
(39.2%).
234
had
no
One
hundred
one
diagnosed
non-rheumatologic
diseases,
11
diseases.
Eleven
diseases
girls.
Rash
predictive
value
disease
3.2%
1.7%
systemic
lupus
erythematosus.
Conclusions:
Due
low
testing,
risk
autoimmune
should
be
identified
carefully
evaluated
before
is
requested.
Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Авг. 24, 2023
Background
Mitochondrial
encephalomyopathy
with
lactic
acidosis
and
stroke-like
episodes
(MELAS)
is
a
group
of
maternally
inherited
disorders
caused
by
mutations
or
deletions
in
mitochondrial
genes
encephalomyopathy,
acidosis,
as
the
main
clinical
manifestations.
Case
presentation
We
reported
20-year-old
female
patient
MELAS
syndrome
combined
autoimmune
abnormalities.
She
suffered
from
an
intermittent
headache
right
temporal
region
no
obvious
cause,
then,
after
strenuous
exercise
dance
class,
became
aggravated,
accompanied
unresponsiveness,
blurred
vision,
diplopia.
Her
blood
lactate
levels
were
elevated,
her
antinuclear
antibodies
positive,
antimetabolic
glutamate
receptors
5
serum
positive.
Brain
DWI
showed
hypertensive
signal
temporo-parietal-occipital
cortex
subcortical
area.
MRS
decreased
NAA
peak
increased
Lac
peak.
Muscle
biopsy
myogenic
damage,
modified
Gomori
trichrome
(MGT)
staining
ragged
red
fibers
(RRF).
A
genetic
study
revealed
DNA
A3243G
mutation.
Conclusion
rare
condition;
however,
association
diseases
not
yet
clear
still
needs
further
research
analysis.
Acta Biomedica Scientifica (East Siberian Biomedical Journal),
Год журнала:
2022,
Номер
7(5-1), С. 62 - 76
Опубликована: Дек. 6, 2022
One
of
the
delayed
consequences
SARS-CoV-2
infection
is
post-acute
COVID-19
–
polymorphic
disorders
various
organ
systems
that
affect
convalescents
and
persist
for
more
than
four
weeks
after
an
acute
infection.
Due
to
infectious
nature
COVID-19,
we
would
like
pay
special
attention
complications
from
immune
system,
especially
concomitant
new-onset
autoimmune
pathology.
This
review
analyzes
current
state
issue
complications,
discusses
molecular
features
virus
mechanisms
underlying
impaired
response
during
occurrence
autoinflammatory
conditions
convalescence.
Particular
paid
mimicry
antigenic
determinants
virus,
which
are
structurally
similar
epitopes
human
autoantigens.
The
data
on
humoral
immunity
endocrine
as
well
reproductive
faced
by
male
patients
presented.
For
first
time,
hypothesize
a
role
structural
homology
SOX13
autoantigen
(HMG
box
factor
SOX13)
associated
with
diabetes
mellitus
envelope
(E)
protein
in
development
pathologies.
similarity
two
proteins
overlap
their
immunogenic
regions,
suggest
increased
risk
developing
men
suffering
may
be
immunological
cross-reactivity.
Sains Malaysiana,
Год журнала:
2023,
Номер
52(3), С. 887 - 898
Опубликована: Март 31, 2023
Antibodi
anti-nuklear
(ANA)
merupakan
salah
satu
contoh
autoantibodi
yang
boleh
terbentuk
sebelum
berlakunya
penyakit
autoimun
terutamanya
reumatik
sistemik.
Disebabkan
itu,
ANA
telah
menjadi
ujian
penting
dipohon
oleh
pakar
klinikal
apabila
seseorang
pesakit
tersebut
disyaki
mempunyai
autoimun.
Terdapat
pelbagai
kaedah
makmal
digunakan
untuk
mengesan
kehadiran
dalam
darah
tetapi
imunofluoresen
dianggap
sebagai
piawai
tujuan
penyaringan
ANA.
Kehadiran
ini
tidaklah
khusus
kepada
kerana
tahap
kesensitifan
dan
kekhususannya
adalah
berbeza-beza
bergantung
jenis
Penggunaan
berbeza
juga
menunjukkan
kadar
kekhususan
Pentafsiran
keputusan
sesuatu
terbatas
dengan
dikesan
kalangan
tidak
malah
mereka
sihat.
Maklumat
unsur
membolehkan
pentafsiran
berkesan
memberikan
panduan
selanjutnya
jika
diperlukan.
Dalam
beberapa
tahun
kebelakangan
ini,
pengujian
menggunakan
mengalami
pembaharuan
termasuklah
penubuhan
Kesepakaran
Corak
Antarabangsa
(ICAP)
pembacaan
slaid
IF
secara
automasi.
Pembaharuan
berlaku
ke
arah
penyeragaman
pelaporan
IF.
Ulasan
merangkumi
ANA,
kegunaan
positif
perkembangan
terkini
Turkish Journal of Pediatric Disease,
Год журнала:
2023,
Номер
unknown, С. 1 - 7
Опубликована: Апрель 25, 2023
Background:
The
aim
of
this
study
was
to
determine
the
reasons
for
request
antinuclear
antibody
(ANA)
in
ANA-positive
patients
and
final
diagnosis
these
whether
they
developed
a
rheumatologic
disease.
Method:
In
retrospective
study,
files
559
with
positive
ANA
were
reviewed.
Demographic,
laboratory
clinical
characteristics
noted.
At
end
follow-up,
recorded.
Results:
included
346
patients.
233
female,
113
male.
mean
age
at
time
positivity
9.4
4.7
years,
follow-up
period
19
5.7
months.
most
common
symptom
myalgia/arthralgia
(21.7%).
Other
urticaria,
abdominal
pain,
thrombocytopenia,
proteinuria.
Extractable
nuclear
antigens
(ENA)
panel
results
negative
170
(49.1%).
ENA
panel,
dense
fine
speckled
antigen
70
antibodies
frequently
135
(39.2%).
234
had
no
One
hundred
one
diagnosed
non-rheumatologic
diseases,
11
diseases.
Eleven
diseases
girls.
Rash
predictive
value
disease
3.2%
1.7%
systemic
lupus
erythematosus.
Conclusions:
Due
low
testing,
risk
autoimmune
should
be
identified
carefully
evaluated
before
is
requested.
