Possibilities of CT in the diagnosis of pulmonary aspergillosis in patients with COVID-19 (literature review) DOI Creative Commons

Myo Tun Nay,

Andrey Yudin, Yu. A. Abovich

и другие.

Medical Visualization, Год журнала: 2023, Номер 27(4), С. 10 - 21

Опубликована: Июль 17, 2023

Aim: to analyze the latest research in field of CT diagnostics pulmonary aspergillosis patients with COVID-19 according domestic and foreign literature. Results. Pulmonary is one most common life-threatening fungal diseases that caused by inhalation Aspergillus mold spores affects all parts respiratory system. In recent years, there has been a sharp increase cases invasive mycotic processes. During pandemic, number authors, incidence reached 34.4%, mortality rate was 74%. The World Health Organization calls for “minimizing disproportionate use corticosteroids antibiotics mild moderate cases”. She explained severe do save lives, but their massive can cause infections. This complication increasingly after corticosteroid antibiotic therapy, immunodeficiency states, as well those treated intensive care units. pandemic created additional challenges diagnosis, treatment prevention complications. clinical radiographic features infections are largely similar typical manifestations COVID-19. A comparative analysis signs various forms before during carried out main symptoms lung lesions among who have undergone identified. Currently, computed tomography crucial, first all, detect monitor complications COVID-19, including addition secondary infection. Conclusion. To make conclusion about mycosis early stages, special vigilance high qualification radiologist required, which turn will contribute timely appointment antifungal reduce morbidity mortality.

Язык: Английский

Influenza-associated and COVID-19-associated pulmonary aspergillosis in critically ill patients DOI
Simon Feys, Agostinho Carvalho, Cornelius J. Clancy

и другие.

The Lancet Respiratory Medicine, Год журнала: 2024, Номер 12(9), С. 728 - 742

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

20
Antibiotic-Resistant ESKAPE Pathogens and COVID-19: The Pandemic beyond the Pandemic DOI Creative Commons
Alessia Catalano, Domenico Iacopetta, Jessica Ceramella

и другие.

Viruses, Год журнала: 2023, Номер 15(9), С. 1843 - 1843

Опубликована: Авг. 30, 2023

Antibacterial resistance is a renewed public health plague in modern times, and the COVID-19 pandemic has rekindled this problem. Changes antibiotic prescribing behavior, misinformation, financial hardship, environmental impact, governance gaps have generally enhanced misuse improper access to antibiotics during pandemic. These determinants, intersected with antibacterial current pandemic, may amplify potential for future The occurrence of infections multidrug-resistant (MDR), extensively drug-resistant (XDR), difficult-to-treat (DTR), carbapenem-resistant (CR), pan-drug-resistant (PDR) bacteria still increasing. aim review highlight state art worldwide, focusing on most important pathogens, namely Enterobacterales, Acinetobacter baumannii, Klebsiella pneumoniae, their common antibiotics.

Язык: Английский

Процитировано

28
High Incidence of Candidemia in Critically Ill COVID-19 Patients Supported by Veno-Venous Extracorporeal Membrane Oxygenation: A Retrospective Study DOI Creative Commons
Francesco Alessandri, Giancarlo Ceccarelli, Giuseppe Migliara

и другие.

Journal of Fungi, Год журнала: 2023, Номер 9(1), С. 119 - 119

Опубликована: Янв. 14, 2023

The incidence of candidemia in severe COVID-19 patients (0.8-14%) is two- to ten-fold higher than non-COVID-19 patients.This retrospective analysis aimed analyse the bloodstream infections (BSI) due Candida a cohort supported with ECMO.Among 138 intubated and ventilated hospitalized for ≥10 days intensive care unit teaching hospital, 45 (32.6%) received ECMO support, while 93 (67.4%) did not meet criteria were considered control group. In group, 16 episodes candidaemia observed, only 13 group (36.0% vs. 14.0%, p-value 0.004). It was confirmed at survival (SHR: 2.86, 95% CI: 1.39-5.88) multivariable analyses (aSHR: 3.91, 1.73-8.86). A candida score seemed increase hazard occurrence 3.04, 2.09-4.42), vasopressor therapy negatively associated outcome 0.15, 0.05-0.43).This study confirms that significantly critically ill VV-ECMO COVID who VV-ECMO.

Язык: Английский

Процитировано

16
Leading Pathogens Involved in Co-Infection and Super-Infection with COVID-19: Forensic Medicine Considerations after a Systematic Review and Meta-Analysis DOI Creative Commons

Roberto Scendoni,

Emanuele Bury,

Isabella Lima Arrais Ribeiro

и другие.

Pathogens, Год журнала: 2023, Номер 12(5), С. 646 - 646

Опубликована: Апрель 27, 2023

The COVID-19 pandemic raised concerns about the potential for co-infection or over-infection with other respiratory infections, as they can complicate diagnosis, treatment and prognosis of disease. This is also a challenge forensic pathologists, who may come across cases where presence suspected confirmed, it important that take this into account when determining cause death. aim systematic review to analyse prevalence each specific pathogen co-infecting over-infecting patients SARS-CoV-2 infection. In total, 575 studies were selected from Scopus Pub-Med online databases 8 included in meta-analysis. Male gender, advanced age nursing home care are risk factors associated development co-infection, whereas age, tachypnoea, hypoxaemia bacterial infection predictors mortality. Overall, however, having does not represent real co-infections/super-infections.

Язык: Английский

Процитировано

13
Prevalence and risk factors of cytomegalovirus reactivation in critically Ill patients with COVID-19 pneumonia DOI Creative Commons
Tanapat Tassaneeyasin, Somnuek Sungkanuparph, Sirawat Srichatrapimuk

и другие.

PLoS ONE, Год журнала: 2024, Номер 19(5), С. e0303995 - e0303995

Опубликована: Май 21, 2024

Backgrounds In critically ill patients with COVID-19, secondary infections are potentially life-threatening complications. This study aimed to determine the prevalence, clinical characteristics, and risk factors of CMV reactivation among immunocompetent COVID-19 pneumonia. Methods A retrospective cohort was conducted adult who were admitted ICU screened for quantitative real-time PCR viral load in a tertiary-care hospital during third wave outbreak Thailand. Cox regression models used identify significant developing reactivation. Results total 185 studied; 133 (71.9%) non-CMV group 52 (28.1%) group. Of all, mean age 64.7±13.3 years 101 (54.6%) males. The had received significantly higher median cumulative dose corticosteroids than (301 vs 177 mg dexamethasone, p <0.001). Other modalities treatments including anti-viral drugs, anti-cytokine drugs hemoperfusion not different between two groups ( >0.05). 90-day mortality rate all 29.1%, difference (42.3% vs. 24.1%, = 0.014). Median length stay longer (43 24 days, has detectable DNA [IQR] 4,977 [1,365–14,742] IU/mL 24,570 [3,703–106,642] plasma bronchoalveolar fluid, respectively. multivariate analysis, only dexamethasone ≥250 (HR 2.042; 95%CI, 1.130–3.688; 0.018) associated Conclusion patients, is frequent high factor reactivation, which poor outcomes. Further prospective studies warranted optimal management.

Язык: Английский

Процитировано

5
COVID-19: Has the Liver Been Spared? DOI Open Access
Nicolò Brandi, Daniele Spinelli, Alessandro Granito

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(2), С. 1091 - 1091

Опубликована: Янв. 6, 2023

The liver is a secondary and often collateral target of COVID-19 disease but can lead to important consequences. might directly cause high number complications in patients with pre-existing chronic disease, increasing their risk hepatic decompensation. Moreover, it also determines indirect consequences the management especially those suffering from decompensated cirrhosis HCC, as well execution follow-up availability all therapeutic possibilities. Liver imaging proved be highly nonspecific, still useful for identifying that derive infection. recent implementation telemedicine constitutes possible solution both physical distancing re-organizational difficulties arising pandemic. present review aims encompass currently hypothesized pathophysiological mechanisms injury mediated by direct invasion virus its effects analyze consequence pandemic tumors, particular regard strategies have been implemented face this worldwide emergency further improved.

Язык: Английский

Процитировано

10
Clinical and pathogen features of COVID-19-associated infections during an Omicron strain outbreak in Guangzhou, China DOI Creative Commons
Linling Cheng, Zhengtu Li, Hongkai Wu

и другие.

Microbiology Spectrum, Год журнала: 2024, Номер unknown

Опубликована: Сен. 6, 2024

ABSTRACT Although the Omicron variant has been associated with greater transmissibility and tropism of upper respiratory tract, clinical pathogenic features patients infected during an outbreak in China have unclear. Adults COVID-19 were retrospectively enrolled from seven medical centers Guangzhou, China, information specimens ( BALF, sputum, throat swabs) participants collected. Conventional detection methods, metagenomics next-generation sequencing (mNGS), other methods used to detect pathogens lower tract samples. From December 2022 January 2023, we 836 COVID-19, among which 56.7% had severe/critical illness. About 91.4% strain (BA.5.2). The rate possible co-infection was 53.4% by mNGS, including Klebsiella pneumoniae (16.3%), Aspergillus fumigatus (12.2%), Pseudomonas aeruginosa (11.8%). 19.5%, common being Streptococcus (11.5%), Haemophilus influenzae (9.2%), Adenovirus (6.9%). superinfection 75.4%, such as (26.1%) (19.4%). (27.1%% vs 6.1%, P < 0.001), (19.6% 5.3%, = Acinetobacter baumannii (18.7% 4.4%, (16.8% 7.0%, 0.024), Staphylococcus aureus (14.0% 0.027), (0.9% 10.5%, 0.002) more severe cases. Co-infection bacteria fungi are pneumonia infection. Sequencing may aid diagnosis differential pathogens. IMPORTANCE Our study analyzed characteristics pathogen spectrum or Guangzhou strain, particularly after relaxation epidemic prevention control strategy China. This will likely prompt further research into specific issue, benefit practice.

Язык: Английский

Процитировано

3
Invasive Candidiasis Coinfection in Patients with Severe COVID-19 Disease: Scoping Review DOI Creative Commons
Omar Esteban Valencia-Ledezma, María del Roció Reyes-Montes,

Gustavo Acosta‐Altamirano

и другие.

Pathogens, Год журнала: 2025, Номер 14(5), С. 466 - 466

Опубликована: Май 10, 2025

Coinfection rates of candidiasis in patients affected by COVID-19 had a significantly increase during the sanitary contingency. The objective this scoping review is to analyze available scientific evidence around coinfection invasive hospitalized with severe disease. Online databases such as PubMed, EBSCO, SciFinder, Scopus, and SciELO were used different studies published from January 2020 December 2022, selecting 48 publications that reported comorbidity between study variable. Based on PRISMA-ScR extension for reviews, we identified more than half (57%) observational, descriptive, analytic studies, while 43% systematic reviews. Overall, up 169,468 adult admitted intensive care unit examined. was due mainly Candida albicans (75%), but some species Meyerozyma parapsilosis (formerly parapsilosis); guilliermondii guilliermondii); Nakaseomyces glabratus glabrata); tropicalis; dubliniensis; Clavispora lusitaniae lusitaniae); Pichia kudriavzevii krusei). We concluded infected SARS-CoV-2 higher incidence fungal coinfections, thus increasing mortality rate, disease severity, length hospital stay unit.

Язык: Английский

Процитировано

0
Challenges of diagnosis of hidden fungal infections as sequelae in post-coronavirus disease patients DOI
Meiliyana Wijaya, Sem Samuel Surja, Hanna Yolanda

и другие.

Reviews in Medical Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Май 14, 2025

More than 700 million people worldwide have been confirmed to coronavirus disease 2019 (COVID-19), putting them at risk of developing sequelae that are prone invasive fungal infections (IFIs), such as candidiasis, aspergillosis, and cryptococcosis. These fungi generally not virulent, but in patients with a history severe acute respiratory syndrome 2 (SARS-CoV-2) infection, they can cause opportunistic due immune dysregulation abnormalities lung tissue structure caused by the effects SARS-CoV-2 virus, using immunosuppressive drugs or medical devices during treatment, so on. The increased susceptibility IFIs individuals post-COVID-19 requires rapid efficient diagnostic methods. Currently, commercially available antigen-based serological tests good sensitivity specificity, some approved for use Food Drug Administration. Thus, screening essential regions limited resources.

Язык: Английский

Процитировано

0
The Antimicrobial Efficacy of Copper Complexes: A Review DOI Creative Commons
Kwanele Ngece, Vuyolwethu Khwaza,

Athandwa M. Paca

и другие.

Antibiotics, Год журнала: 2025, Номер 14(5), С. 516 - 516

Опубликована: Май 16, 2025

The alarming increase in antimicrobial resistance has intensified the search for novel therapeutic agents capable of combating resistant microbial strains. Copper complexes have emerged as promising due to their intrinsic redox activity, ability disrupt membranes, and interactions with vital biomolecules such DNA proteins. This review critically evaluates potential copper reported between 2018 2025, emphasizing structural diversity, mechanisms action, biological performance against a wide range bacterial fungal pathogens. Key findings reveal that Schiff base complexes, amino acid derivatives, heterocyclic ligands, mixed-ligand systems exhibit potent activities, often surpassing standard antibiotics. Mechanistically, induce reactive oxygen species (ROS) generation, inhibit enzyme function, cause cleavage, compromise cell membrane integrity. Furthermore, structure-activity relationship (SAR) analyses indicate ligand type, coordination geometry, lipophilicity significantly influence efficacy. Overall, reviewed studies support development copper-based compounds viable candidates drug development. also identifies current challenges gaps knowledge, limited vivo toxicity assessments, which must be addressed advance these toward clinical application.

Язык: Английский

Процитировано

0