Frontiers in Cellular and Infection Microbiology, Год журнала: 2024, Номер 14
Опубликована: Дек. 10, 2024
Human immunodeficiency Virus (HIV) and
Язык: Английский
Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(8)
Опубликована: Авг. 22, 2024
The chemokine receptor CXCR3 and its ligands (MIG/CXCL9, IP-10/CXCL10, I-TAC/CXCL11) play a central role in the generation of cellular inflammation, both protective responses to invading pathogens, different pathological conditions associated with autoimmunity. It is worth noting that highly expressed on innate adaptive lymphocytes, as well various cell subsets are localized non-immune organs tissues. Our review focuses exclusively CXCR3-expressing T cells, including Th1, Th17.1, Tfh17, Tfh17.1, CXCR3+ Treg Tc1 CD8+ cells. Currently, numerous studies have highlighted CXCR3-dependent interactions coordination inflammation peripheral tissues, increase recruitment CD4+ cells upregulate also for regulatory dampen overexuberant responses. Understanding might help apply them new effective therapeutic targets wide range diseases.
Язык: Английский
Процитировано
6
Frontiers in Medicine, Год журнала: 2025, Номер 12
Опубликована: Фев. 5, 2025
The combination of tuberculosis and pregnancy always raises questions about therapy, the specialness management pregnancy, obstetrics, postpartum period, lactation; effect therapy on fetal development peculiarities course. Until recently, were considered a rare combination, but with growing problem HIV infection worsening screening among adults, this has become quite common. Moreover, cases congenital in newborns have begun to emerge. In review, we analyzed features immunologic immuno-neuroendocrine reactivity pregnant women that influence for prevalence TB TB/HIV coinfection. changes characteristic multifactorial antituberculosis immunity determine specificity course against background pregnancy. These contribute more severe than before structure clinical forms who became ill during first year after childbirth is characterized by greater severity, higher frequency multi-organ lesions, percentage bacterial isolates significantly developed period compared it poses particular threat, exacerbating immune response disorders affect effectiveness treatment disease progression general.
Язык: Английский
Процитировано
0
International Journal of Mycobacteriology, Год журнала: 2025, Номер 14(1), С. 2 - 3
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Pathogens, Год журнала: 2025, Номер 14(4), С. 370 - 370
Опубликована: Апрель 9, 2025
Tuberculosis (TB) remains a leading cause of mortality, with drug resistance highlighting the need for new vaccine targets. Peptidyl-prolyl isomerase A (PpiA), conserved Mycobacterium tuberculosis (Mtb) protein, plays role in bacterial stress adaptation and immune evasion, making it potential target immunotherapy. This study uses computational methods to assess PpiA's antigenicity, structural integrity, immunogenic potential. The PpiA sequence was retrieved from NCBI analyzed antigenicity allergenicity using VaxiJen, AllerTOP, AllergenFP. Physicochemical properties were evaluated ProtParam, models generated through PSIPRED SWISS-MODEL. Structural validation performed MolProbity, QMEANDisCo, ProSA-Web. B-cell epitopes predicted BepiPred 2.0 IEDB, while T-cell mapped via IEDB's MHC-I MHC-II tools. Epitope conservation across Mtb strains confirmed ConSurf. Results indicate is highly antigenic, non-allergenic, stable, several identified both B- T-cells. supports as promising TB development.
Язык: Английский
Процитировано
0
Viruses, Год журнала: 2025, Номер 17(5), С. 606 - 606
Опубликована: Апрель 24, 2025
Herpes simplex virus (HSV)-specific CD8+ T cells protect mice from herpes infection and disease. However, the phenotype function of HSV-specific that play a key role in "natural" protection seen HSV-1-seropositive healthy asymptomatic (ASYMP) patients (who have never had clinical disease) remain to be determined. We previously reported symptomatic (SYMP) frequent bouts recurrent ocular more undifferentiated dysfunctional cells. In contrast, ASYMP individuals maintained significantly higher proportion differentiated polyfunctional Here, we report 10 SYMP patients, but not phenotypic functional characteristics cellular senescence, including: (i) high frequency senescent (CD57+) exhausted (PD-1+) cells; (ii) late terminally (KLRG1+), non-proliferating (iii) which decreased number over time were homeostatically maintained, as indicated by reduction CD127+CD8+ (iv) loss co-stimulatory molecule CD28 on (v) production effector molecules (granzyme B perforin) Our findings provide insights into senescence susceptibility implications for T-cell-based immunotherapeutic strategies against humans.
Язык: Английский
Процитировано
0
Human Vaccines & Immunotherapeutics, Год журнала: 2024, Номер 20(1)
Опубликована: Янв. 23, 2024
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) persistently kills nearly 1.5 million lives per year in the world, whereas only licensed TB vaccine BCG exhibits unsatisfactory efficacy adults. Taking as a vehicle to express Mtb antigens is promising way enhance its against infection. In this study, immune of recombination (rBCG-ECD003) expressing specific ESAT-6, CFP-10, and nDnaK was evaluated at different time points after immunizing BALB/c mice. The results revealed that rBCG-ECD003 induced multiple Th1 cytokine secretion including IFN-γ, TNF-α, IL-2, IL-12 when compared parental BCG. Under action PPD or ECD003, immunization resulted significant increase proportion IL-2+ IFN-γ+IL-2+ CD4+T cells. Importantly, stronger long-term humoral response without compromising safety vaccine. By means protective assay vitro, showed greater capacity inhibit growth long term. Collectively, these features indicate protection effect controlling
Язык: Английский
Процитировано
2
ImmunoTargets and Therapy, Год журнала: 2024, Номер Volume 13, С. 335 - 342
Опубликована: Июль 1, 2024
Tuberculosis (TB) is a major public health problem worldwide, and the burden of drug-resistant TB rapidly increasing. Although there are literatures about
Язык: Английский
Процитировано
1
Frontiers in Tuberculosis, Год журнала: 2024, Номер 2
Опубликована: Сен. 30, 2024
Despite advancements in modern medicine, tuberculosis continues to be one of the leading causes death globally. Findings indicate that COVID-19 may trigger activation infection (TB), its spread. development new immunological diagnostic methods for latent (LTBI), it is still unclear how transitions an active TB state. The goal study provide insights into progression from a This article presents recent research data focused on investigating pathogenesis LTBI, particularly immune responses interaction between Mycobacteria (Mtb) and host. It describes mechanisms T-cell immunity cytokine activation, supporting concept type 1, 2, 3 responses. According conducted studies, Th17 cells have significant role antigen-specific cytokines IL-6 IL-23 activate STAT3, which necessary expression Th17. Future cytokines, IL-21, beneficial understanding shift LTBI TB.
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 22, 2024
Introduction Tuberculosis remains the leading cause of death from infectious diseases among adults worldwide. To date, an overarching review immune response to Mtb in humans has not been fully elucidated, with innate immunity remaining poorly understood due historic focus on adaptive immunity. Specifically, there is a major gap concerning contribution system overall bacterial clearance, particularly residual bacteria. This aims describe time course interactions between host and , start infection development response. Concordantly, we aim crystallize pathogenic effects immunoevasive mechanisms . The translational value animal data also discussed. Methods literature search was conducted PubMed, ScienceDirect, Google Scholar databases, which included reported research 1990 until 2024. A total 190 publications were selected screened, 108 used for abstraction 86 extraction. Graphical summaries created using narrative information (i.e., recruitment, recognition, response) generate clear visual representations at cellular molecular levels. Results key players airway epithelial cells, alveolar neutrophils, natural killer macrophages, dendritic T granulomatous lesions; prominent IFN-γ, TNF-α, IL-10. paper sheds light bacteria applications data. Discussion We provide comprehensive characterization that are implicated pulmonary tuberculosis, line organs or compartments mycobacteria reside, offering broad vignette how it responds Ultimately, presented could immunological insights help establish optimized criteria identifying efficacious treatment regimens durations relapse prevention modeling simulation space wider fields.
Язык: Английский
Процитировано
1
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Ноя. 3, 2024
ABSTRACT Adjuvants are immuno-activators capable of shaping the magnitude and quality antigen-specific immune responses induced by subunit immunization. Presently, there is an acute need for effective adjuvants that safely induce durable balanced humoral cellular responses; latter being indispensable protection against intracellular pathogens cancer. Here, we iteratively optimized a novel class Amphiphile (AMP)-modified, immunostimulatory DNA-adjuvants designed targeted delivery to lymph nodes enhanced stimulation cytosolic danger-sensing pathways generate strong adaptive immunity. AMP-DNA potent IFN-I-driven inflammatory environments in mouse NHP were dependent on TBK1 signaling, leading significantly cytokine secretion polyfunctional CD8 + CD4 T cells multiple tissues, strongly elevated H 1-associated neutralizing antibody responses, without toxicity. These results demonstrate AMP-engineering enables node-targeted uniquely activate immune-signaling robust crucial vaccine efficacy.
Язык: Английский
Процитировано
0