A two-center prospective cohort study of serum RIP-3 as a potential biomarker in relation to severity and prognosis after severe traumatic brain injury
Shengdong Zou,
Jian Xu,
Wenjie Yang
и другие.
Neurosurgical Review,
Год журнала:
2024,
Номер
47(1)
Опубликована: Авг. 14, 2024
Язык: Английский
Osteonecrosis of the femoral head in post-COVID-19 patients: a retrospective comparative study
Journal of Orthopaedic Surgery and Research,
Год журнала:
2025,
Номер
20(1)
Опубликована: Апрель 10, 2025
Abstract
Background
The
COVID-19
pandemic
has
claimed
many
lives
and
continues
to
impact
individuals
through
post-COVID-19
conditions.
Osteonecrosis
of
the
femoral
head
(ONFH)
is
increasingly
recognized
as
a
major
complication,
yet
most
studies
are
limited
case
reports
small
series.
This
study
aimed
evaluate
COVID-19-related
factors
potentially
contributing
ONFH
development
in
patients.
Methods
A
retrospective
analysis
was
conducted
on
84
patients
with
confirmed
history
COVID-19.
Baseline
characteristics
were
collected,
categorized
into
following
groups
for
comparative
analysis:
(1)
vaccinated
vs.
unvaccinated,
(2)
unilateral
bilateral
ONFH,
(3)
dexamethasone
(DEX)
methylprednisolone
(MPS)
DEX
therapy,
(4)
Association
Research
Circulation
Osseus
(ARCO)
stage
2
3.
Group
differences
associations
analyzed.
Results
MPS-treated
group
had
greater
extent
lung
involvement
compared
DEX-treated
(59.2%
36.3%,
p
=
0.002),
well
longer
hospital
stays
both
general
ward
(14.2
days
10.6
days,
0.018)
ICU
(5.4
3
0.017).
also
duration
steroid
therapy
(19.3
12.3
<
0.001)
received
higher
DEX-equivalent
cumulative
doses
(380
mg
125
mg,
0.001).
Notably,
symptoms
developed
earlier
(7.5
months
12
months,
0.004).
Multivariable
logistic
regression
identified
dose
sole
predictor
severity
(OR:
1.015,
95%
CI:
1.001–1.028,
0.032),
ARCO
receiving
than
(240
126
0.018).
Conclusions
Our
demonstrated
that
primary
determinant
Additionally,
combined
use
corticosteroids
may
accelerate
onset
highlighting
need
cautious
management
Язык: Английский
Simultaneous Bilateral Avascular Necrosis of the Humerus and Femur in Long COVID-19: A Case Report
Traumatology and Orthopedics of Russia,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
This
case
report
presents
a
rare
instance
of
simultaneous
bilateral
avascular
necrosis
(AVN)
affecting
both
the
humeral
and
femoral
heads
in
49-year-old
male
patient
recovering
from
severe
COVID-19.
The
was
treated
with
high-dose
corticosteroids,
receiving
1250
mg
prednisolone
over
five
days
during
hospitalization
for
COVID-19
pneumonia.
Six
months
after
discharge,
he
developed
persistent
hip
pain,
which
later
diagnosed
as
AVN
heads.
During
hyperbaric
oxygen
therapy,
reported
new
shoulder
an
MRI
confirmed
stage
3
patient’s
pain
managed
suprascapular
nerve
radiofrequency
ablation
Pericapsular
Nerve
Group
(PENG)
blocks,
provided
significant
relief.
emphasizes
potential
corticosteroid-induced
AVN,
even
treatment,
underscores
need
long-term
monitoring
patients
corticosteroids
involvement
four
major
joints
highlights
musculoskeletal
complications
that
can
arise,
supporting
importance
early
diagnosis
timely
intervention
Язык: Английский
Osteonecrose da cabeça femoral por uso de corticosteroides no tratamento da COVID-19: relato de caso
Revista de Medicina,
Год журнала:
2024,
Номер
103(4)
Опубликована: Авг. 29, 2024
Non-traumatic
osteonecrosis
of
the
femoral
head
(ONHF)
is
characterized
by
cell
death
osteocytes
and
alterations
in
osteoblasts
osteoclasts,
often
caused
prolonged
use
corticosteroids.
Other
risk
factors
include
autoimmune
diseases,
alcohol,
radiotherapy
infections.
This
report
describes
case
a
55-year-old
man
who
developed
ONHF
after
treatment
with
corticosteroids
for
COVID-19.
can
be
insidious,
manifesting
pain
limited
movement,
magnetic
resonance
imaging
(MRI)
being
most
effective
diagnostic
method.
Treatment
varies
from
conservative
to
surgical,
depending
on
stage
disease.
Early
diagnosis
multidisciplinary
follow-up
are
essential
better
prognosis.
Future
research
should
focus
developing
COVID-19
guidelines
that
reduce
incidence
ONCF,
exploring
safe
therapeutic
alternatives.
Язык: Английский