The Known, the Unknown and the Future of the Pathophysiology of Endometriosis

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5815 - 5815

Опубликована: Май 27, 2024

Endometriosis is one of the most common causes chronic pelvic pain and infertility, affecting 10% women reproductive age. A delay up to 9 years estimated between onset symptoms diagnosis endometriosis. currently defined as presence endometrial epithelial stromal cells at ectopic sites; however, advances in research on endometriosis have some authors believing that should be re-defined “a fibrotic condition which stroma epithelium can identified”. There are several theories etiology disease, but origin remains unclear. This review addresses role microRNAs (miRNAs), naturally occurring post-transcriptional regulatory molecules, endometriotic lesion development, inflammatory environment within peritoneal cavity, including cytokines play during development how animal models helped our understanding pathology this enigmatic disease.

Язык: Английский

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Understanding the impact of endometriosis on women’s life: an integrative review of systematic reviews

BMC Women s Health, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 19, 2024

Язык: Английский

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Landscape of Endometrial Cancer: Molecular Mechanisms, Biomarkers, and Target Therapy

Cancers, Год журнала: 2024, Номер 16(11), С. 2027 - 2027

Опубликована: Май 27, 2024

Endometrial cancer is one the most prevalent gynecological cancers and, unfortunately, has a poor prognosis due to low response rates traditional treatments. However, progress in molecular biology and understanding genetic mechanisms involved tumor processes offers valuable information that led current classification describes four subtypes of endometrial cancer. This review focuses on pathogenesis cancers, such as mutations, defects DNA mismatch repair pathway, epigenetic changes, or dysregulation angiogenic hormonal signaling pathways. The preclinical genomic investigations presented allowed for identification some molecules could be used biomarkers diagnose, predict, monitor progression Besides therapies known clinical practice, targeted therapy described new treatment involves identifying specific targets cells. By selectively inhibiting these targets, key pathways can disrupted while normal cells are protected. connection between vital fight against Ongoing research trials exploring use standard agents combination with other strategies like immunotherapy anti-angiogenesis improve outcomes personalize patients approach potential transform management patients. In conclusion, enhancing tools essential stratifying risk guiding surgery, adjuvant therapy, women addition, from this may have an value personalized patient’s life.

Язык: Английский

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A transcriptomic analysis of the interplay of ferroptosis and immune filtration in endometriosis and identification of novel therapeutic targets

Computational Biology and Chemistry, Год журнала: 2025, Номер 115, С. 108343 - 108343

Опубликована: Янв. 7, 2025

Язык: Английский

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The Role of Mast Cells in the Development and Advancement of Endometriosis

American Journal of Reproductive Immunology, Год журнала: 2025, Номер 93(3)

Опубликована: Март 1, 2025

ABSTRACT Endometriosis is a medical condition identified by the presence of endometrium‐like tissue outside uterus. This known to result in symptoms such as frequent pelvic pain, infertility, and irregularities menstrual cycle. The development endometriosis complex and, involving abnormal body responses, hormonal imbalances, genetic predispositions. Although common affects quality life, its mechanisms progression are not fully understood. Mast cells (MCs), type immune cell, renowned for their involvement allergic inflammatory responses. These essential modulation system process through secretion different mediators like histamine, cytokines, proteases. In recent years, MCs have been shown play role pathogenesis many diseases, including endometriosis. article explores relationship between endometriosis, disease development, pain perception, angiogenesis, other important processes. It elucidates how MCs, via mediators, actively participate associated environment. Moreover, research emphasizes potential targeting therapeutic approach treating Insight into interplay holds promise developing innovative strategies manage this effectively.

Язык: Английский

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Analysis of the Biopsychosocial Impacts Associated with Endometriosis to Improve Patient Care

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(7), С. 2158 - 2158

Опубликована: Март 21, 2025

Endometriosis is a non-malignant, inflammatory condition that impacts individuals across various hormonal stages, including before their first menstruation, throughout reproductive years, and after menopause. This arises when tissue resembling the uterine lining grows outside uterus, resulting in inflammation range of symptoms, such as dysmenorrhea, pain during intercourse, chronic discomfort, challenges with fertility. review provides comprehensive analysis medical strategies implemented to address pathology endometriosis, highlighting its significant impact on quality life affected by this condition. can influence aspects life, physical health, emotional well-being, social interactions, professional performance. Usually, assess women validated instruments, different questionnaire types, are used measure physical, psychological, social, health impacts. To improve experiencing several supportive proposed. The findings underscore necessity managing endometriosis through multidisciplinary approach encompasses both surgical interventions, lifestyle modifications, psychological support.

Язык: Английский

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Association between triglyceride-glucose index and endometriosis: results from a cross-sectional study and Mendelian randomization study

Frontiers in Endocrinology, Год журнала: 2025, Номер 15

Опубликована: Янв. 9, 2025

Triglyceride-glucose (TyG) index has been found to be associated with female reproductive disorders, but its relationship the risk of endometriosis is unknown. Therefore, aim this study was investigate relationship. We performed a two-sample mendelian randomization(MR) analysis examine causal effect TyG on endometriosis, and inverse variance weighting(IVW) main method analysis. Then, we selected 1484 participants from National Health Nutrition Examination Survey (NHANES) 1999 2006. Weighted multivariable-adjusted logistic regression smoothed curve were used evaluate correlation between endometriosis. The results MR confirmed that higher causally (OR=1.27, 95%CI: 1.05-1.54, P=0.01). In cross-sectional study, subjects in highest quartile had incident after adjusting for covariates(OR = 2.41, 95% CI:1.31-4.44, P trend <0.01). also revealed positive linear Our confirms an increased by study. These findings suggested could serve as biomarker identifying individuals who may at developing Further research needed explore potential clinical implications these elucidate underlying mechanisms behind observed

Язык: Английский

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Understanding Deep Endometriosis: From Molecular to Neuropsychiatry Dimension

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 839 - 839

Опубликована: Янв. 20, 2025

Endometriosis is a widely spread disease that affects about 8% of the world’s female population. This condition may be described as endometrial tissue apart from uterine cavity, but this process’s pathomechanism still unsure. Apart classic endometriosis symptoms, which are pelvic pain, infertility, and bleeding problems, there neuropsychiatric comorbidities usually difficult to diagnose. In our review, we attempted summarize some them. Conditions like migraine, anxiety, depression occur more often in women with have significant impact on life quality pain perception. Interestingly, 77% patients also anxiety. Neuroimaging gives an image so-called brain, means alternations processing cognition, self-regulation, reward. Genetic factors, including mutations KRAS, PTEN, ARID1A, influence cellular proliferation, differentiation, chromatin remodeling, potentially exacerbating lesion severity complicating treatment. focused aspects sciatic obturator nerve endometriosis, emotional well-being endometriosis-affected patients, potential dementia, focusing prolonged diagnosis. Addressing requires multidisciplinary approach, encompassing molecular insights, innovative therapies, attention its psychological systemic effects.

Язык: Английский

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TMED9: a potential therapeutic target and prognostic marker in glioma and its implications across pan-cancer contexts

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 7, 2025

Background The escalating global cancer burden, projected to reach 35 million new cases by 2050, underscores the urgent need for innovative biomarkers improve treatment efficacy and patient outcomes. TMED family, particularly TMED9, has garnered attention its involvement in progression; however, comprehensive role across various types remains poorly understood. Methods Utilizing multi-omics data, we analyzed expression pattern, prognostic significance, genomic alterations, immunological features of TMED9 types. Through vitro experiments, paid special glioma, especially correlation with glioma cell migration invasion behavior. Results Our findings reveal that is significantly overexpressed tumor tissues associated poor prognosis cancers such as glioblastoma lower-grade gliomas. Genetic analysis shows mutations predominantly kidney renal clear carcinoma, linked chromosomal instability. Immunological indicates correlates positively immune infiltration, macrophages, suggesting promoting immunity. Furthermore, was negatively correlated stemness, indicating potential influence on chemotherapy resistance. Knockdown led reduced lines. Conclusions positions a critical player progression modulation, Elevated poorer outcomes may serve marker therapeutic target. Future research should focus elucidating TMED9’s mechanistic pathways validating clinical settings enhance strategies.

Язык: Английский

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The Molecular and Cellular Mechanisms of Endometriosis: From Basic Pathophysiology to Clinical Implications

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2458 - 2458

Опубликована: Март 10, 2025

Endometriosis is a complex gynecological disorder characterized by endometrial-like tissue growing outside the uterus, leading to chronic pain, infertility, and reduced quality of life. Its pathophysiology involves genetic, epigenetic, immune, molecular factors. Theories such as retrograde menstruation, coelomic metaplasia, stem cell involvement explain lesion formation. Endometrial mesenchymal cells (eMSCs) epithelial progenitors (eEPs) contribute establishment adhering peritoneal surfaces, proliferating, differentiating into ectopic tissue. Aberrant adhesion molecules, inflammatory cytokines, pathways like PI3K/Akt Wnt/β-catenin drive proliferation, angiogenesis, resistance apoptosis. Elevated estrogen levels progesterone further promote growth immune evasion. Immune dysfunction, including altered macrophage activity natural killer (NK) function, contributes inflammation persistence. Pain linked prostaglandin E2 (PGE2) nerve infiltration, emphasizing need for targeted pain management. Current therapies, GnRH agonists, suppress ovarian hormone production but face limitations in long-term efficacy side effects. Integrating insights clinical practice may advance diagnostics treatment, with emerging approaches focusing on pathways, modulation, hormonal regulation more effective, personalized therapies. Future research should unravel mechanisms driving endometriosis improve patient outcomes.

Язык: Английский

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