
Neuroinformatics, Год журнала: 2024, Номер 22(4), С. 591 - 606
Опубликована: Ноя. 6, 2024
Abstract
The
black
box
nature
of
deep
neural
networks
(DNNs)
makes
researchers
and
clinicians
hesitant
to
rely
on
their
findings.
Saliency
maps
can
enhance
DNN
explainability
by
suggesting
the
anatomic
localization
relevant
brain
features.
This
study
compares
seven
popular
attribution-based
saliency
approaches
assign
neuroanatomic
interpretability
DNNs
that
estimate
biological
age
(BA)
from
magnetic
resonance
imaging
(MRI).
Cognitively
normal
(CN)
adults
(
N
=
13,394,
5,900
males;
mean
age:
65.82
±
8.89
years)
are
included
for
training,
testing,
validation,
map
generation
BA.
To
robustness
presence
deviations
normality,
also
generated
with
mild
traumatic
injury
(mTBI,
$$N$$
Язык: Английский