Ligilactobacillus salivarius PS11610 Enhances the Fertilization Success of IVF: A Preliminary Retrospective Analysis

Nutrients, Год журнала: 2025, Номер 17(3), С. 410 - 410

Опубликована: Янв. 23, 2025

Background/Objectives: Infertility affects couples at reproductive age, with in vitro fertilization (IVF) being the most effective treatment. Success rates of IVF are influenced by several factors, including a healthy female system microbiome, which can improve implantation and pregnancy outcomes. This study evaluated impact Ligilactobacillus salivarius PS11610 on strain showed antimicrobial activity against pathogens related to dysbiosis, commonly observed women undergoing assisted Results: The administration L. dose 1 × 109 CFU every 12 h for least one month before procedures, particularly frozen embryo transfer (FET) group, appears enhance success rate IVF. procedures without no significant differences between groups. However, there were statistically quality embryos, specifically category 2, higher group supplementation (p = 0.042). Similar results seen where embryos categories 2 3 was 0.019 p 0.05, respectively). FET notable improvements, intake associated increase live birth infants (26.4% vs. 17.9% without, 0.034) biochemical (42.6% 34%, 0.071). Conclusions: Despite some quality, overall positive outcomes highlights as promising supplement treatments.

Язык: Английский

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Health Benefits of Prebiotics, Probiotics, Synbiotics, and Postbiotics

Nutrients, Год журнала: 2024, Номер 16(22), С. 3955 - 3955

Опубликована: Ноя. 19, 2024

The trillions of microbes that constitute the human gut microbiome play a crucial role in digestive health, immune response regulation, and psychological wellness. Maintaining microbiota is essential as metabolic diseases are associated with it. Functional food ingredients potentially improving health include prebiotics, probiotics, synbiotics, postbiotics (PPSPs). While probiotics living bacteria provide advantages when ingested sufficiently, prebiotics non-digestible carbohydrates support good bacteria. Synbiotics work together to improve immunity intestinal by combining prebiotics. Postbiotics have also demonstrated numerous advantages, such bioactive molecules created during probiotic fermentation. According recent study, PPSPs can regulate synthesis metabolites, integrity barrier, change composition control illnesses. Additionally, use fecal transplantation (FMT) highlights potential for restoring through modulation, reinforcing benefits enhancing overall well-being. Research has shown several benefits, improved immunological function, alleviation symptoms irritable bowel disease (IBD), decreased severity allergies, antibacterial anti-inflammatory effects. Despite encouraging results, many unanswered questions remain about scope PPSPs' advantages. Extensive research required fully realize these functional components Effective therapeutic prophylactic measures require further investigation into roles PPSPs, specifically their immune-system-modulating, cholesterol-lowering, antioxidant, characteristics.

Язык: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Год журнала: 2025, Номер 13(2), С. 241 - 241

Опубликована: Янв. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Язык: Английский

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Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies

Biomedicines, Год журнала: 2024, Номер 12(7), С. 1398 - 1398

Опубликована: Июнь 24, 2024

The functions of the gut are closely related to those many other organs in human body. Indeed, microbiota (GM) metabolize several nutrients and compounds that, once released bloodstream, can reach distant organs, thus influencing metabolic inflammatory tone host. main microbiota-derived metabolites responsible for modulation endocrine responses short-chain fatty acids (SCFAs), bile glucagon-like peptide 1 (GLP-1). These molecules (i) regulate pancreatic hormones (insulin glucagon), (ii) increase glycogen synthesis liver, (iii) boost energy expenditure, especially skeletal muscles brown adipose tissue. In words, they critical maintaining glucose lipid homeostasis. GM dysbiosis, imbalance microbiota-related products affect proper functions, including gut–liver–pancreas axis (GLPA). addition, dysbiosis contribute onset some diseases such as non-alcoholic steatohepatitis (NASH)/non-alcoholic liver disease (NAFLD), hepatocellular carcinoma (HCC), type 2 diabetes (T2D). this review, we explored roles their involvement progression these diseases. detailed microbiota-modulating strategies that could improve diseases’ development by restoring healthy balance GLPA.

Язык: Английский

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Impact of Probiotics and Prebiotics on Gut Microbiome and Hormonal Regulation

Gastrointestinal Disorders, Год журнала: 2024, Номер 6(4), С. 801 - 815

Опубликована: Сен. 27, 2024

The gut microbiome plays a crucial role in human health by influencing various physiological functions through complex interactions with the endocrine system. These involve production of metabolites, signaling molecules, and direct communication cells, which modulate hormone secretion activity. As result, can exert neuroendocrine effects contribute to metabolic regulation, adiposity, appetite control. Additionally, influences reproductive altering levels sex hormones such as estrogen testosterone, potentially contributing conditions like polycystic ovary syndrome (PCOS) hypogonadism. Given these roles, targeting offers researchers clinicians novel opportunities improve overall well-being. Probiotics,

Язык: Английский

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Gastrointestinal Microbiota in Gastric Cancer: Potential Mechanisms and Clinical Applications—A Literature Review

Cancers, Год журнала: 2024, Номер 16(20), С. 3547 - 3547

Опубликована: Окт. 21, 2024

Emerging evidence highlights the crucial role of gastrointestinal microbiota in pathogenesis gastric cancer.

Язык: Английский

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The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5765 - 5765

Опубликована: Май 25, 2024

The pancreas is an organ with both exocrine and endocrine functions, comprising a highly organized complex tissue microenvironment composed of diverse cellular non-cellular components. impairment microenvironmental homeostasis, mediated by the dysregulation cell-to-cell crosstalk, can lead to pancreatic diseases such as pancreatitis, diabetes, cancer. Macrophages, key immune effector cells, dynamically modulate their polarization status between pro-inflammatory (M1) anti-inflammatory (M2) modes, critically influencing homeostasis thus playing pivotal role in pathogenesis disease. This review aims summarize current findings provide detailed mechanistic insights into how alterations macrophage contribute disorders. By analyzing research comprehensively, this article endeavors deepen our understanding regulatory molecules that affect polarity intricate crosstalk regulates function within microenvironment, thereby facilitating development innovative therapeutic strategies target perturbations microenvironment.

Язык: Английский

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Correlation Between Systemic Inflammation, Gut Microbiome Dysbiosis and Postoperative Complications After the Modified Whipple Procedure

Biomedicines, Год журнала: 2025, Номер 13(1), С. 104 - 104

Опубликована: Янв. 5, 2025

(1) Background: The modified Whipple procedure, or pylorus-preserving pancreaticoduodenectomy, is a complex surgical intervention used to treat pancreatic head tumors. While preserving digestive function, it associated with significant perioperative risks. This study explores the clinical, immunological, and microbiome-related factors influencing postoperative complications, focusing on interplay between patient comorbidities, systemic inflammation, gut dysbiosis. (2) Methods: A retrospective analysis was conducted 123 patients undergoing procedure for Patients were categorized into two groups based occurrence of complications (Group A: complications; Group B: without complications). Data demographics, inflammatory markers (CRP, IL-6, procalcitonin), microbiome composition collected. Microbial diversity evaluated using Shannon Index, logistic regression performed identify independent predictors complications. (3) Results: in had significantly higher prevalence diabetes mellitus (43.1% vs. 20.8%; p = 0.02) cardiovascular disease (35.3% 13.9%; 0.01). Elevated (CRP ≥ 40 mg/L, IL-6 30 pg/mL, procalcitonin 0.5 ng/mL) strongly complication rates. Microbiome indicated dysbiosis A, reduced Lactobacillus Bifidobacterium levels, increased Enterobacteriaceae abundance, lower Index (<2). exhibiting both elevated inflammation highest rate (60%). Multivariate identified diabetes, as adverse outcomes. (4) Conclusions: Postoperative after are influenced by systematic preoperative assessment health enables accurate risk stratification personalized interventions, potentially reducing incidence improving overall

Язык: Английский

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Unveiling Microbiota Profiles in Saliva and Pancreatic Tissues of Patients with Pancreatic Cancer

Microorganisms, Год журнала: 2025, Номер 13(1), С. 119 - 119

Опубликована: Янв. 9, 2025

The pancreas, previously considered a sterile organ, has recently been shown to harbor its own microbiota that may influence tumor biology and patient outcomes. Despite increasing interest in the impact of microbiome on cancer, relationship between pancreatic tissue oral microbiomes ductal adenocarcinoma (PDAC) remains limited. In this study, pancreas patients with PDAC were compared other periampullary cancers (DC/AC) healthy control group using 16S rRNA gene sequence analysis. results showed significant reduction microbial diversity saliva cancer controls, while exhibited distinct profile their tissues, consisting predominantly Firmicutes, Proteobacteria, Actinobacter, after filtering indoor environment. Notably, presence bacteria such as Anoxybacillus, Clostridium, Bacillus tissues suggests potential translocation from cavity. This study emphasizes importance understanding role body fluid proposing dysbiosis contribute disease progression. Moreover, suggest environment which samples are collected analyzed is also important analysis studies.

Язык: Английский

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Positive Intraoperative Bile Culture and Antibiotic Resistance Increase the Risk of Pancreatic Fistula in Patients After Pancreatoduodenectomy

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 455 - 455

Опубликована: Янв. 12, 2025

Background/Objectives: A positive intraoperative bile culture (bacterobilia) is considered to be a risk factor for increased morbidity after pancreatoduodenectomy. The aim of our study was describe the frequency bacterobilia with special emphasis on antibiotic resistance and analyze association these findings postoperative complications, in particular pancreatic fistula. Methods: From prospective database, patients available cultures (n = 95) were selected analyzed. Microbiological test results reported type bacteria as well sensitivity patterns. Associations between results, resistance, outcomes assessed. Results: Among 95 that included this trial, 71 (74.7%) had culture. total 29.6% (21/71) developed POPF grade B/C compared 8.3% (2/24) negative (p 0.052). difference CR-POPF became statistically significant when at least one isolated microorganisms resistant ampicillin/sulbactam, perioperative administered prophylaxis. diagnosed 38.5% (15/39) vs. 14.3% (8/56) without 0.007). We also identified isolation Enterococcus spp. 0.006), Enterobacter 0.031), or Escherichia coli 0.027) factors Conclusions: antibiotic-resistant strains major development fistula most relevant spp., cloacae, coli. Thus, broad-spectrum antimicrobial prophylaxis efficacy against low rates should routinely perioperatively.

Язык: Английский

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