Health Benefits of Prebiotics, Probiotics, Synbiotics, and Postbiotics

Nutrients, Год журнала: 2024, Номер 16(22), С. 3955 - 3955

Опубликована: Ноя. 19, 2024

The trillions of microbes that constitute the human gut microbiome play a crucial role in digestive health, immune response regulation, and psychological wellness. Maintaining microbiota is essential as metabolic diseases are associated with it. Functional food ingredients potentially improving health include prebiotics, probiotics, synbiotics, postbiotics (PPSPs). While probiotics living bacteria provide advantages when ingested sufficiently, prebiotics non-digestible carbohydrates support good bacteria. Synbiotics work together to improve immunity intestinal by combining prebiotics. Postbiotics have also demonstrated numerous advantages, such bioactive molecules created during probiotic fermentation. According recent study, PPSPs can regulate synthesis metabolites, integrity barrier, change composition control illnesses. Additionally, use fecal transplantation (FMT) highlights potential for restoring through modulation, reinforcing benefits enhancing overall well-being. Research has shown several benefits, improved immunological function, alleviation symptoms irritable bowel disease (IBD), decreased severity allergies, antibacterial anti-inflammatory effects. Despite encouraging results, many unanswered questions remain about scope PPSPs' advantages. Extensive research required fully realize these functional components Effective therapeutic prophylactic measures require further investigation into roles PPSPs, specifically their immune-system-modulating, cholesterol-lowering, antioxidant, characteristics.

Язык: Английский

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Key Insights into Gut Alterations in Metabolic Syndrome

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(8), С. 2678 - 2678

Опубликована: Апрель 14, 2025

Over time, extensive research has underscored the pivotal role of gut microbiota in onset and progression various diseases, with a particular focus on fecal transplantation (FMT) as potential therapeutic approach. The practice transferring matter from healthy donor to patient provides valuable insights into how alterations can impact disease development rectifying dysbiosis may offer benefits. Re-establishing balanced symbiotic relationship gastrointestinal tract shown positive results managing both intestinal systemic conditions. Currently, one most pressing global health issues is metabolic syndrome—a cluster conditions that includes insulin resistance, lipid imbalances, central obesity hypertension. In this context, FMT emerged promising strategy for addressing key components syndrome, such improving sensitivity, body weight profiles. However, further well-structured studies are needed refine treatment protocols establish long-term safety efficacy intervention.

Язык: Английский

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Ligilactobacillus salivarius PS11610 Enhances the Fertilization Success of IVF: A Preliminary Retrospective Analysis

Nutrients, Год журнала: 2025, Номер 17(3), С. 410 - 410

Опубликована: Янв. 23, 2025

Background/Objectives: Infertility affects couples at reproductive age, with in vitro fertilization (IVF) being the most effective treatment. Success rates of IVF are influenced by several factors, including a healthy female system microbiome, which can improve implantation and pregnancy outcomes. This study evaluated impact Ligilactobacillus salivarius PS11610 on strain showed antimicrobial activity against pathogens related to dysbiosis, commonly observed women undergoing assisted Results: The administration L. dose 1 × 109 CFU every 12 h for least one month before procedures, particularly frozen embryo transfer (FET) group, appears enhance success rate IVF. procedures without no significant differences between groups. However, there were statistically quality embryos, specifically category 2, higher group supplementation (p = 0.042). Similar results seen where embryos categories 2 3 was 0.019 p 0.05, respectively). FET notable improvements, intake associated increase live birth infants (26.4% vs. 17.9% without, 0.034) biochemical (42.6% 34%, 0.071). Conclusions: Despite some quality, overall positive outcomes highlights as promising supplement treatments.

Язык: Английский

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Impact of Probiotics and Prebiotics on Gut Microbiome and Hormonal Regulation

Gastrointestinal Disorders, Год журнала: 2024, Номер 6(4), С. 801 - 815

Опубликована: Сен. 27, 2024

The gut microbiome plays a crucial role in human health by influencing various physiological functions through complex interactions with the endocrine system. These involve production of metabolites, signaling molecules, and direct communication cells, which modulate hormone secretion activity. As result, can exert neuroendocrine effects contribute to metabolic regulation, adiposity, appetite control. Additionally, influences reproductive altering levels sex hormones such as estrogen testosterone, potentially contributing conditions like polycystic ovary syndrome (PCOS) hypogonadism. Given these roles, targeting offers researchers clinicians novel opportunities improve overall well-being. Probiotics,

Язык: Английский

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Gut–Liver–Pancreas Axis Crosstalk in Health and Disease: From the Role of Microbial Metabolites to Innovative Microbiota Manipulating Strategies

Biomedicines, Год журнала: 2024, Номер 12(7), С. 1398 - 1398

Опубликована: Июнь 24, 2024

The functions of the gut are closely related to those many other organs in human body. Indeed, microbiota (GM) metabolize several nutrients and compounds that, once released bloodstream, can reach distant organs, thus influencing metabolic inflammatory tone host. main microbiota-derived metabolites responsible for modulation endocrine responses short-chain fatty acids (SCFAs), bile glucagon-like peptide 1 (GLP-1). These molecules (i) regulate pancreatic hormones (insulin glucagon), (ii) increase glycogen synthesis liver, (iii) boost energy expenditure, especially skeletal muscles brown adipose tissue. In words, they critical maintaining glucose lipid homeostasis. GM dysbiosis, imbalance microbiota-related products affect proper functions, including gut–liver–pancreas axis (GLPA). addition, dysbiosis contribute onset some diseases such as non-alcoholic steatohepatitis (NASH)/non-alcoholic liver disease (NAFLD), hepatocellular carcinoma (HCC), type 2 diabetes (T2D). this review, we explored roles their involvement progression these diseases. detailed microbiota-modulating strategies that could improve diseases’ development by restoring healthy balance GLPA.

Язык: Английский

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From Dysbiosis to Hepatic Inflammation: A Narrative Review on the Diet-Microbiota-Liver Axis in Steatotic Liver Disease

Microorganisms, Год журнала: 2025, Номер 13(2), С. 241 - 241

Опубликована: Янв. 23, 2025

The gut microbiota has emerged as a critical player in metabolic and liver health, with its influence extending to the pathogenesis progression of steatotic diseases. This review delves into gut-liver axis, dynamic communication network linking microbiome through metabolic, immunological, inflammatory pathways. Dysbiosis, characterized by altered microbial composition, contributes significantly development hepatic steatosis, inflammation, fibrosis via mechanisms such barrier dysfunction, metabolite production, systemic inflammation. Dietary patterns, including Mediterranean diet, are highlighted for their role modulating microbiota, improving axis integrity, attenuating injury. Additionally, emerging microbiota-based interventions, fecal transplantation bacteriophage therapy, show promise therapeutic strategies disease. However, challenges population heterogeneity, methodological variability, knowledge gaps hinder translational application current findings. Addressing these barriers standardized approaches integrative research will pave way microbiota-targeted therapies mitigate global burden

Язык: Английский

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The Pivotal Role of Macrophages in the Pathogenesis of Pancreatic Diseases

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5765 - 5765

Опубликована: Май 25, 2024

The pancreas is an organ with both exocrine and endocrine functions, comprising a highly organized complex tissue microenvironment composed of diverse cellular non-cellular components. impairment microenvironmental homeostasis, mediated by the dysregulation cell-to-cell crosstalk, can lead to pancreatic diseases such as pancreatitis, diabetes, cancer. Macrophages, key immune effector cells, dynamically modulate their polarization status between pro-inflammatory (M1) anti-inflammatory (M2) modes, critically influencing homeostasis thus playing pivotal role in pathogenesis disease. This review aims summarize current findings provide detailed mechanistic insights into how alterations macrophage contribute disorders. By analyzing research comprehensively, this article endeavors deepen our understanding regulatory molecules that affect polarity intricate crosstalk regulates function within microenvironment, thereby facilitating development innovative therapeutic strategies target perturbations microenvironment.

Язык: Английский

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Understanding the Conundrum of Pancreatic Cancer in the Omics Sciences Era

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7623 - 7623

Опубликована: Июль 11, 2024

Pancreatic cancer (PC) is an increasing cause of cancer-related death, with a dismal prognosis caused by its aggressive biology, the lack clinical symptoms in early phases disease, and inefficacy treatments. PC characterized complex tumor microenvironment. The interaction cellular components plays crucial role development progression, contributing to alteration metabolism hyperproliferation, as well metastatic evolution abnormal tumor-associated immunity. Furthermore, response intrinsic oncogenic alterations influence microenvironment, cells undergo oncogene-directed metabolic reprogramming that includes changes glucose utilization, lipid amino acid metabolism, redox balance, activation recycling scavenging pathways. advent omics sciences revolutionizing comprehension pathogenetic conundrum pancreatic carcinogenesis. In particular, metabolomics genomics has led more precise classification into subtypes show different biological behaviors responses identification molecular targets through pharmacogenomic approach may help personalize Novel specific biomarkers have been discovered using proteomics analyses. Radiomics allows for earlier diagnosis computational analysis imaging. However, complexity, high expertise required, costs are main limitations use practice at present. addition, studies extracellular vesicles (EVs), organoids, understanding host–microbiota interactions, recently artificial intelligence helping make further steps towards precision personalized medicine. This present review summarizes evidence application study future perspectives.

Язык: Английский

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Gastrointestinal Microbiota in Gastric Cancer: Potential Mechanisms and Clinical Applications—A Literature Review

Cancers, Год журнала: 2024, Номер 16(20), С. 3547 - 3547

Опубликована: Окт. 21, 2024

Emerging evidence highlights the crucial role of gastrointestinal microbiota in pathogenesis gastric cancer.

Язык: Английский

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Phosphatidylcholine in Intestinal Mucus Protects against Mucosal Invasion of Microbiota and Consequent Inflammation

Livers, Год журнала: 2024, Номер 4(3), С. 479 - 494

Опубликована: Сен. 23, 2024

Intestinal mucus serves as the first line barrier within mucosa to protect against microbiota attack due its water-repellent properties, which are result of high abundance phosphatidylcholine bound mucins. A deficiency predisposes it mucosal inflammation by commensal microbiota, is intrinsically low in ulcerative colitis. However, for precipitation an acute inflammatory episode, has fall below critical level required protection. Bacterial ectophospholipase could be a candidate further thinning shield shown, example, with containing Helicobacter pylori bacterium. Despite supporting evidence this mechanism intestine, responsible ectophospholipase-carrying bacteria species still defined. Applying lumen can serve fill up empty mucin-binding sites colitis well provide substrate preventing their attacks on layer. Evidence concept comes from clinical trials humans mouse models where was substituted lumen. An alternative strategy involve adding non-absorbable phospholipase inhibitors intestinal lumen, been shown effective model should considered pathogenetic factor and therapeutic strategies developed prevent hyperactivity improvement inflammation.

Язык: Английский

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