Correlation Between Systemic Inflammation, Gut Microbiome Dysbiosis and Postoperative Complications After the Modified Whipple Procedure

Biomedicines, Год журнала: 2025, Номер 13(1), С. 104 - 104

Опубликована: Янв. 5, 2025

(1) Background: The modified Whipple procedure, or pylorus-preserving pancreaticoduodenectomy, is a complex surgical intervention used to treat pancreatic head tumors. While preserving digestive function, it associated with significant perioperative risks. This study explores the clinical, immunological, and microbiome-related factors influencing postoperative complications, focusing on interplay between patient comorbidities, systemic inflammation, gut dysbiosis. (2) Methods: A retrospective analysis was conducted 123 patients undergoing procedure for Patients were categorized into two groups based occurrence of complications (Group A: complications; Group B: without complications). Data demographics, inflammatory markers (CRP, IL-6, procalcitonin), microbiome composition collected. Microbial diversity evaluated using Shannon Index, logistic regression performed identify independent predictors complications. (3) Results: in had significantly higher prevalence diabetes mellitus (43.1% vs. 20.8%; p = 0.02) cardiovascular disease (35.3% 13.9%; 0.01). Elevated (CRP ≥ 40 mg/L, IL-6 30 pg/mL, procalcitonin 0.5 ng/mL) strongly complication rates. Microbiome indicated dysbiosis A, reduced Lactobacillus Bifidobacterium levels, increased Enterobacteriaceae abundance, lower Index (<2). exhibiting both elevated inflammation highest rate (60%). Multivariate identified diabetes, as adverse outcomes. (4) Conclusions: Postoperative after are influenced by systematic preoperative assessment health enables accurate risk stratification personalized interventions, potentially reducing incidence improving overall

Язык: Английский

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Unveiling Microbiota Profiles in Saliva and Pancreatic Tissues of Patients with Pancreatic Cancer

Microorganisms, Год журнала: 2025, Номер 13(1), С. 119 - 119

Опубликована: Янв. 9, 2025

The pancreas, previously considered a sterile organ, has recently been shown to harbor its own microbiota that may influence tumor biology and patient outcomes. Despite increasing interest in the impact of microbiome on cancer, relationship between pancreatic tissue oral microbiomes ductal adenocarcinoma (PDAC) remains limited. In this study, pancreas patients with PDAC were compared other periampullary cancers (DC/AC) healthy control group using 16S rRNA gene sequence analysis. results showed significant reduction microbial diversity saliva cancer controls, while exhibited distinct profile their tissues, consisting predominantly Firmicutes, Proteobacteria, Actinobacter, after filtering indoor environment. Notably, presence bacteria such as Anoxybacillus, Clostridium, Bacillus tissues suggests potential translocation from cavity. This study emphasizes importance understanding role body fluid proposing dysbiosis contribute disease progression. Moreover, suggest environment which samples are collected analyzed is also important analysis studies.

Язык: Английский

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Positive Intraoperative Bile Culture and Antibiotic Resistance Increase the Risk of Pancreatic Fistula in Patients After Pancreatoduodenectomy

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(2), С. 455 - 455

Опубликована: Янв. 12, 2025

Background/Objectives: A positive intraoperative bile culture (bacterobilia) is considered to be a risk factor for increased morbidity after pancreatoduodenectomy. The aim of our study was describe the frequency bacterobilia with special emphasis on antibiotic resistance and analyze association these findings postoperative complications, in particular pancreatic fistula. Methods: From prospective database, patients available cultures (n = 95) were selected analyzed. Microbiological test results reported type bacteria as well sensitivity patterns. Associations between results, resistance, outcomes assessed. Results: Among 95 that included this trial, 71 (74.7%) had culture. total 29.6% (21/71) developed POPF grade B/C compared 8.3% (2/24) negative (p 0.052). difference CR-POPF became statistically significant when at least one isolated microorganisms resistant ampicillin/sulbactam, perioperative administered prophylaxis. diagnosed 38.5% (15/39) vs. 14.3% (8/56) without 0.007). We also identified isolation Enterococcus spp. 0.006), Enterobacter 0.031), or Escherichia coli 0.027) factors Conclusions: antibiotic-resistant strains major development fistula most relevant spp., cloacae, coli. Thus, broad-spectrum antimicrobial prophylaxis efficacy against low rates should routinely perioperatively.

Язык: Английский

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The Association of Statin Therapy with Liver and Pancreatic Fat Fraction in Type 2 Diabetes Mellitus

Diagnostics, Год журнала: 2025, Номер 15(4), С. 426 - 426

Опубликована: Фев. 10, 2025

Background/Objectives: It has been shown that the use of statins in patients with type 2 diabetes mellitus (T2DM) worsens hyperglycemia and hemoglobin A1c levels but may help preservation pancreatic β-cell function. The potential role a high fat fraction (PFF) this process not yet clarified. This study aimed to investigate whether liver (LFF) PFF T2DM is affected by statin therapy. Methods: cross-sectional involved total 140 patients, including both those who were receiving (n = 70) mapping LFF utilizing IDEAL-IQ sequence was conducted magnetic resonance imaging. Results: In used statins, median higher compared did (8.4 vs. 6.2%, p 0.021), while found be similar 8.9, 0.572). Variations associated various (non-statin group: 6.2 atovastatin: 8.7 rosuvastatin: 3.2 pitavastatin: 9.2, 0.004). multivariable regression analysis indicated insulin usage decreased log(LFF) factor 0.16-fold (ꞵ ± SE -0.16 0.05, 0.010), rosuvastatin reduced log(PFF) 0.07, 0.025), irrespective other risk factors. Furthermore, atorvastatin 0.17 0.06, 0.011) pitavastatin 0.19 0.008) independently an increase log(PFF). Conclusions: T2DM, show significant effect on fraction, it caused differences fraction. observation lower taking dose 40 mg/day suggests different types doses have varying effects accumulation.

Язык: Английский

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Inflammatory Stimuli and Fecal Microbiota Transplantation Accelerate Pancreatic Carcinogenesis in Transgenic Mice, Accompanied by Changes in the Microbiota Composition

Cells, Год журнала: 2025, Номер 14(5), С. 361 - 361

Опубликована: Фев. 28, 2025

An association between gut microbiota and the development of pancreatic ductal adenocarcinoma (PDAC) has been previously described. To better understand bacterial changes accompanying PDAC promotion progression stimulated by inflammation fecal transplantation (FMT), we investigated stool 16s RNA-based metagenomic analysis in mice with inducible acinar transgenic expressions KrasG12D, age- sex-matched control that were exposed to inflammatory stimuli obtained from PDAC. Time- inflammatory-dependent composition alterations alpha diversity reduction observed only a Kras mutation developed advanced changes. Stool Actinobacteriota abundance Bifidobacterium abundances increased. In contrast, Firmicutes, Verrucomicrobiota, Spirochaetota, Desulfobacterota, Butyricicoccus, Roseburia, Lachnospiraceae A2, unclassified, Oscillospiraceae unclassified decreased, detection Alloprevotella uncultured was not observed. Furthermore, FMT accelerated tumorigenesis, gradually decreased diversity, changed microbial mutation. Specifically, Actinobacteriota, Faecalibaculum increased, while genera such as Lachnospiraceace A2 ASF356, Desulfovibrionaceace uncultured, Roseburia decreased. conclusion, carcinogenesis presence an oncogenic chronic dynamically pancreas microbiota. particular, decrease bacteria known be involved short-fatty acids production mouse model can used for further research on microbiota-PDAC interactions towards more personalized effective cancer therapies.

Язык: Английский

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Interplay Between Gut Microbiota and Exosome Dynamics in Sleep Apnea

Sleep Medicine, Год журнала: 2025, Номер unknown, С. 106493 - 106493

Опубликована: Апрель 1, 2025

Язык: Английский

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A systematic Mendelian randomized study of the effects of the gut microbiome and immune cells on pancreatic neuroendocrine tumors

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Май 30, 2025

Язык: Английский

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Exploring the gut microbiome’s influence on cancer-associated anemia: Mechanisms, clinical challenges, and innovative therapies

World Journal of Gastrointestinal Pharmacology and Therapeutics, Год журнала: 2025, Номер 16(2)

Опубликована: Июнь 3, 2025

BACKGROUND Anemia is a prevalent and challenging complication in patients with hematologic solid malignancies, which stems from the direct effects of malignancy, treatment-induced toxicities, systemic inflammation. It affects patients’ survival, functional status, quality life profoundly. Recent literature has highlighted emerging role gut microbiome pathogenesis cancer-associated anemia. The microbiota, through its intricate interplay iron metabolism, inflammatory pathways, immune modulation, may either exacerbate or ameliorate anemia depending on composition, integrity. Dysbiosis, characterized by disruption microbial ecosystem, very common cancer patients. This imbalance implicated causation diminished absorption, persistent low-grade inflammation, suppression erythropoiesis. AIM To consolidate current evidence regarding between setting malignancies. aims to provide detailed exploration mechanistic links dysbiosis anemia, identifies unique challenges associated various types, evaluates efficacy microbiome-focused therapies. Through this integrative approach, review seeks establish foundation for innovative clinical strategies aimed at mitigating improving patient outcomes oncology. METHODS A search was performed using multiple databases, including Google Scholar, PubMed, Scopus, Web Science, combination keywords Boolean operators refine results. Keywords included “cancer-associated anemia”, “gut microbiome”, “intestinal microbiota”, “iron metabolism”, dysbiosis”, “short-chain fatty acids”, “hematopoiesis”, “probiotics”, “prebiotics”, “fecal microbiota transplantation”. Articles published English 2000 December 2024 were included, focus contemporary relevant findings. RESULTS Therapeutic restoration homeostasis, such as probiotics, prebiotics, dietary interventions, fecal transplantation (FMT), can inhibit anemia-causing pathways enhancing diversity, suppressing detrimental flora, reducing inflammation optimizing nutrient absorption. CONCLUSION Gut causes impairs response chemotherapy Microbiome-centered modifications, FMT, have shown restoring balance, bioavailability. Emerging approaches, engineered probiotics bacteriophage therapies, are promising precision-based, customizable solutions compositions imbalances. Future research should integrating microbiome-targeted established

Язык: Английский

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Surgical Outcomes of Pancreatic Solid Pseudopapillary Neoplasm: Experiences of 24 Patients in a Single Institute

Medicina, Год журнала: 2024, Номер 60(6), С. 889 - 889

Опубликована: Май 28, 2024

Background and Objectives: The pancreatic solid pseudopapillary neoplasm (SPN), a rare tumor predominantly affecting young women, has seen an increased incidence due to improved imaging epidemiological knowledge. This study aimed understand the outcomes of different interventions, possible complications, associated risk factors. Materials Methods: retrospectively analyzed 24 patients who underwent surgery for SPNs between September 1998 July 2020. Results: Surgical intervention, typically required symptomatic cases or pathological confirmation, yielded favorable with 5-year survival rate up 97%. Despite challenges in standardizing preoperative evaluation follow-up protocols, aggressive complete resection showed promising long-term good oncological outcomes. Notably, no significant differences were found conventional minimally invasive (MI) perioperative Histopathological correlations lacking prognosis locations. Among patients, one developed diffuse liver metastases 41 months postoperatively but responded well chemotherapy transcatheter arterial chemoembolization, disease stability observed at 159 postoperative months. Another patient nonalcoholic steatohepatitis after transplantation, succumbing poor medication adherence 115 surgery. Conclusions: These findings underscore importance surgical intervention managing suggest MI approach as viable option comparable

Язык: Английский

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Beneficial Effects of Probiotic Lactobacillus paraplantarum BGCG11 on Pancreatic and Duodenum Function in Diabetic Rats

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7697 - 7697

Опубликована: Июль 13, 2024

Diabetes mellitus, as a chronic metabolic disorder, significantly impacts the pancreas and among other organs, affects duodenal function. Emerging evidence suggests that probiotics can exert beneficial effects on gut health metabolism. In our previous research, we evaluated probiotic Lactobacillus paraplantarum BGCG11 primarily for its protective properties against diabetic rats’ damaged liver kidneys. this work, further examined of strain function duodenum in rats. We explored potential mechanisms underlying probiotic’s effects, focusing general indicators diabetes, architecture morphology pancreatic islets, integrity (measuring transfer fluid serum zonulin level), modulation microbiota composition. Our findings reveal regulatory roles L. mitigating diabetes-induced dysfunction regardless application time (pre- or post-treatment), highlighting therapeutic managing diabetes-related gastrointestinal complications.

Язык: Английский

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