Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(18), С. 5584 - 5584
Опубликована: Сен. 20, 2024
Background:
The
early
diagnosis
of
pancreatic
cancer
(ICD-10
C25)
can
improve
the
patient’s
prognosis.
association
between
and
type
2
diabetes
(T2D)
is
known,
but
not
yet
fully
understood.
It
is,
therefore,
necessary
to
investigate
impact
hemoglobin
A1c
(HbA1c)
serum
levels
on
development
potential
intervention
options.
Methods:
In
case–control
study,
patients
from
German
IQVIATM
Disease
Analyzer
database
aged
≥18
years
with
a
T2D
(ICD-10:
E11)
were
included.
patients’
propensity
score
matched
1:5
individuals
without
cancer.
Logistic
regression
models
used
estimate
odds
ratios
(ORs)
95%
confidence
intervals
(95%
CI).
Results:
An
elevated
HbA1c
prior
index
date
was
found
be
significantly
associated
an
increased
risk
subsequent
for
mean
values
6.5–8.4%
(OR:
1.38;
CI:
1.22–1.57)
as
well
≥8.5%
1.41;
1.16–1.73).
only
antihyperglycemic
agent
negatively
sodium–glucose
cotransporter-2
(SGLT-2)
inhibitor,
ratio
0.80
interval:
0.74–0.87
per
year
therapy).
This
correlation
observed
in
both
age-
sex-stratified
subgroups.
Conclusions:
data
indicate
that
are
development.
possible
SGLT2
therapy
may
prove
effective
means
reducing
cancer,
thereby
offering
avenue
future
reduction
incidence
T2D.
Biomedicines,
Год журнала:
2025,
Номер
13(1), С. 104 - 104
Опубликована: Янв. 5, 2025
(1)
Background:
The
modified
Whipple
procedure,
or
pylorus-preserving
pancreaticoduodenectomy,
is
a
complex
surgical
intervention
used
to
treat
pancreatic
head
tumors.
While
preserving
digestive
function,
it
associated
with
significant
perioperative
risks.
This
study
explores
the
clinical,
immunological,
and
microbiome-related
factors
influencing
postoperative
complications,
focusing
on
interplay
between
patient
comorbidities,
systemic
inflammation,
gut
dysbiosis.
(2)
Methods:
A
retrospective
analysis
was
conducted
123
patients
undergoing
procedure
for
Patients
were
categorized
into
two
groups
based
occurrence
of
complications
(Group
A:
complications;
Group
B:
without
complications).
Data
demographics,
inflammatory
markers
(CRP,
IL-6,
procalcitonin),
microbiome
composition
collected.
Microbial
diversity
evaluated
using
Shannon
Index,
logistic
regression
performed
identify
independent
predictors
complications.
(3)
Results:
in
had
significantly
higher
prevalence
diabetes
mellitus
(43.1%
vs.
20.8%;
p
=
0.02)
cardiovascular
disease
(35.3%
13.9%;
0.01).
Elevated
(CRP
≥
40
mg/L,
IL-6
30
pg/mL,
procalcitonin
0.5
ng/mL)
strongly
complication
rates.
Microbiome
indicated
dysbiosis
A,
reduced
Lactobacillus
Bifidobacterium
levels,
increased
Enterobacteriaceae
abundance,
lower
Index
(<2).
exhibiting
both
elevated
inflammation
highest
rate
(60%).
Multivariate
identified
diabetes,
as
adverse
outcomes.
(4)
Conclusions:
Postoperative
after
are
influenced
by
systematic
preoperative
assessment
health
enables
accurate
risk
stratification
personalized
interventions,
potentially
reducing
incidence
improving
overall
Microorganisms,
Год журнала:
2025,
Номер
13(1), С. 119 - 119
Опубликована: Янв. 9, 2025
The
pancreas,
previously
considered
a
sterile
organ,
has
recently
been
shown
to
harbor
its
own
microbiota
that
may
influence
tumor
biology
and
patient
outcomes.
Despite
increasing
interest
in
the
impact
of
microbiome
on
cancer,
relationship
between
pancreatic
tissue
oral
microbiomes
ductal
adenocarcinoma
(PDAC)
remains
limited.
In
this
study,
pancreas
patients
with
PDAC
were
compared
other
periampullary
cancers
(DC/AC)
healthy
control
group
using
16S
rRNA
gene
sequence
analysis.
results
showed
significant
reduction
microbial
diversity
saliva
cancer
controls,
while
exhibited
distinct
profile
their
tissues,
consisting
predominantly
Firmicutes,
Proteobacteria,
Actinobacter,
after
filtering
indoor
environment.
Notably,
presence
bacteria
such
as
Anoxybacillus,
Clostridium,
Bacillus
tissues
suggests
potential
translocation
from
cavity.
This
study
emphasizes
importance
understanding
role
body
fluid
proposing
dysbiosis
contribute
disease
progression.
Moreover,
suggest
environment
which
samples
are
collected
analyzed
is
also
important
analysis
studies.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(2), С. 455 - 455
Опубликована: Янв. 12, 2025
Background/Objectives:
A
positive
intraoperative
bile
culture
(bacterobilia)
is
considered
to
be
a
risk
factor
for
increased
morbidity
after
pancreatoduodenectomy.
The
aim
of
our
study
was
describe
the
frequency
bacterobilia
with
special
emphasis
on
antibiotic
resistance
and
analyze
association
these
findings
postoperative
complications,
in
particular
pancreatic
fistula.
Methods:
From
prospective
database,
patients
available
cultures
(n
=
95)
were
selected
analyzed.
Microbiological
test
results
reported
type
bacteria
as
well
sensitivity
patterns.
Associations
between
results,
resistance,
outcomes
assessed.
Results:
Among
95
that
included
this
trial,
71
(74.7%)
had
culture.
total
29.6%
(21/71)
developed
POPF
grade
B/C
compared
8.3%
(2/24)
negative
(p
0.052).
difference
CR-POPF
became
statistically
significant
when
at
least
one
isolated
microorganisms
resistant
ampicillin/sulbactam,
perioperative
administered
prophylaxis.
diagnosed
38.5%
(15/39)
vs.
14.3%
(8/56)
without
0.007).
We
also
identified
isolation
Enterococcus
spp.
0.006),
Enterobacter
0.031),
or
Escherichia
coli
0.027)
factors
Conclusions:
antibiotic-resistant
strains
major
development
fistula
most
relevant
spp.,
cloacae,
coli.
Thus,
broad-spectrum
antimicrobial
prophylaxis
efficacy
against
low
rates
should
routinely
perioperatively.
Diagnostics,
Год журнала:
2025,
Номер
15(4), С. 426 - 426
Опубликована: Фев. 10, 2025
Background/Objectives:
It
has
been
shown
that
the
use
of
statins
in
patients
with
type
2
diabetes
mellitus
(T2DM)
worsens
hyperglycemia
and
hemoglobin
A1c
levels
but
may
help
preservation
pancreatic
β-cell
function.
The
potential
role
a
high
fat
fraction
(PFF)
this
process
not
yet
clarified.
This
study
aimed
to
investigate
whether
liver
(LFF)
PFF
T2DM
is
affected
by
statin
therapy.
Methods:
cross-sectional
involved
total
140
patients,
including
both
those
who
were
receiving
(n
=
70)
mapping
LFF
utilizing
IDEAL-IQ
sequence
was
conducted
magnetic
resonance
imaging.
Results:
In
used
statins,
median
higher
compared
did
(8.4
vs.
6.2%,
p
0.021),
while
found
be
similar
8.9,
0.572).
Variations
associated
various
(non-statin
group:
6.2
atovastatin:
8.7
rosuvastatin:
3.2
pitavastatin:
9.2,
0.004).
multivariable
regression
analysis
indicated
insulin
usage
decreased
log(LFF)
factor
0.16-fold
(ꞵ
±
SE
-0.16
0.05,
0.010),
rosuvastatin
reduced
log(PFF)
0.07,
0.025),
irrespective
other
risk
factors.
Furthermore,
atorvastatin
0.17
0.06,
0.011)
pitavastatin
0.19
0.008)
independently
an
increase
log(PFF).
Conclusions:
T2DM,
show
significant
effect
on
fraction,
it
caused
differences
fraction.
observation
lower
taking
dose
40
mg/day
suggests
different
types
doses
have
varying
effects
accumulation.
Cells,
Год журнала:
2025,
Номер
14(5), С. 361 - 361
Опубликована: Фев. 28, 2025
An
association
between
gut
microbiota
and
the
development
of
pancreatic
ductal
adenocarcinoma
(PDAC)
has
been
previously
described.
To
better
understand
bacterial
changes
accompanying
PDAC
promotion
progression
stimulated
by
inflammation
fecal
transplantation
(FMT),
we
investigated
stool
16s
RNA-based
metagenomic
analysis
in
mice
with
inducible
acinar
transgenic
expressions
KrasG12D,
age-
sex-matched
control
that
were
exposed
to
inflammatory
stimuli
obtained
from
PDAC.
Time-
inflammatory-dependent
composition
alterations
alpha
diversity
reduction
observed
only
a
Kras
mutation
developed
advanced
changes.
Stool
Actinobacteriota
abundance
Bifidobacterium
abundances
increased.
In
contrast,
Firmicutes,
Verrucomicrobiota,
Spirochaetota,
Desulfobacterota,
Butyricicoccus,
Roseburia,
Lachnospiraceae
A2,
unclassified,
Oscillospiraceae
unclassified
decreased,
detection
Alloprevotella
uncultured
was
not
observed.
Furthermore,
FMT
accelerated
tumorigenesis,
gradually
decreased
diversity,
changed
microbial
mutation.
Specifically,
Actinobacteriota,
Faecalibaculum
increased,
while
genera
such
as
Lachnospiraceace
A2
ASF356,
Desulfovibrionaceace
uncultured,
Roseburia
decreased.
conclusion,
carcinogenesis
presence
an
oncogenic
chronic
dynamically
pancreas
microbiota.
particular,
decrease
bacteria
known
be
involved
short-fatty
acids
production
mouse
model
can
used
for
further
research
on
microbiota-PDAC
interactions
towards
more
personalized
effective
cancer
therapies.
World Journal of Gastrointestinal Pharmacology and Therapeutics,
Год журнала:
2025,
Номер
16(2)
Опубликована: Июнь 3, 2025
BACKGROUND
Anemia
is
a
prevalent
and
challenging
complication
in
patients
with
hematologic
solid
malignancies,
which
stems
from
the
direct
effects
of
malignancy,
treatment-induced
toxicities,
systemic
inflammation.
It
affects
patients’
survival,
functional
status,
quality
life
profoundly.
Recent
literature
has
highlighted
emerging
role
gut
microbiome
pathogenesis
cancer-associated
anemia.
The
microbiota,
through
its
intricate
interplay
iron
metabolism,
inflammatory
pathways,
immune
modulation,
may
either
exacerbate
or
ameliorate
anemia
depending
on
composition,
integrity.
Dysbiosis,
characterized
by
disruption
microbial
ecosystem,
very
common
cancer
patients.
This
imbalance
implicated
causation
diminished
absorption,
persistent
low-grade
inflammation,
suppression
erythropoiesis.
AIM
To
consolidate
current
evidence
regarding
between
setting
malignancies.
aims
to
provide
detailed
exploration
mechanistic
links
dysbiosis
anemia,
identifies
unique
challenges
associated
various
types,
evaluates
efficacy
microbiome-focused
therapies.
Through
this
integrative
approach,
review
seeks
establish
foundation
for
innovative
clinical
strategies
aimed
at
mitigating
improving
patient
outcomes
oncology.
METHODS
A
search
was
performed
using
multiple
databases,
including
Google
Scholar,
PubMed,
Scopus,
Web
Science,
combination
keywords
Boolean
operators
refine
results.
Keywords
included
“cancer-associated
anemia”,
“gut
microbiome”,
“intestinal
microbiota”,
“iron
metabolism”,
dysbiosis”,
“short-chain
fatty
acids”,
“hematopoiesis”,
“probiotics”,
“prebiotics”,
“fecal
microbiota
transplantation”.
Articles
published
English
2000
December
2024
were
included,
focus
contemporary
relevant
findings.
RESULTS
Therapeutic
restoration
homeostasis,
such
as
probiotics,
prebiotics,
dietary
interventions,
fecal
transplantation
(FMT),
can
inhibit
anemia-causing
pathways
enhancing
diversity,
suppressing
detrimental
flora,
reducing
inflammation
optimizing
nutrient
absorption.
CONCLUSION
Gut
causes
impairs
response
chemotherapy
Microbiome-centered
modifications,
FMT,
have
shown
restoring
balance,
bioavailability.
Emerging
approaches,
engineered
probiotics
bacteriophage
therapies,
are
promising
precision-based,
customizable
solutions
compositions
imbalances.
Future
research
should
integrating
microbiome-targeted
established
Medicina,
Год журнала:
2024,
Номер
60(6), С. 889 - 889
Опубликована: Май 28, 2024
Background
and
Objectives:
The
pancreatic
solid
pseudopapillary
neoplasm
(SPN),
a
rare
tumor
predominantly
affecting
young
women,
has
seen
an
increased
incidence
due
to
improved
imaging
epidemiological
knowledge.
This
study
aimed
understand
the
outcomes
of
different
interventions,
possible
complications,
associated
risk
factors.
Materials
Methods:
retrospectively
analyzed
24
patients
who
underwent
surgery
for
SPNs
between
September
1998
July
2020.
Results:
Surgical
intervention,
typically
required
symptomatic
cases
or
pathological
confirmation,
yielded
favorable
with
5-year
survival
rate
up
97%.
Despite
challenges
in
standardizing
preoperative
evaluation
follow-up
protocols,
aggressive
complete
resection
showed
promising
long-term
good
oncological
outcomes.
Notably,
no
significant
differences
were
found
conventional
minimally
invasive
(MI)
perioperative
Histopathological
correlations
lacking
prognosis
locations.
Among
patients,
one
developed
diffuse
liver
metastases
41
months
postoperatively
but
responded
well
chemotherapy
transcatheter
arterial
chemoembolization,
disease
stability
observed
at
159
postoperative
months.
Another
patient
nonalcoholic
steatohepatitis
after
transplantation,
succumbing
poor
medication
adherence
115
surgery.
Conclusions:
These
findings
underscore
importance
surgical
intervention
managing
suggest
MI
approach
as
viable
option
comparable
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7697 - 7697
Опубликована: Июль 13, 2024
Diabetes
mellitus,
as
a
chronic
metabolic
disorder,
significantly
impacts
the
pancreas
and
among
other
organs,
affects
duodenal
function.
Emerging
evidence
suggests
that
probiotics
can
exert
beneficial
effects
on
gut
health
metabolism.
In
our
previous
research,
we
evaluated
probiotic
Lactobacillus
paraplantarum
BGCG11
primarily
for
its
protective
properties
against
diabetic
rats’
damaged
liver
kidneys.
this
work,
further
examined
of
strain
function
duodenum
in
rats.
We
explored
potential
mechanisms
underlying
probiotic’s
effects,
focusing
general
indicators
diabetes,
architecture
morphology
pancreatic
islets,
integrity
(measuring
transfer
fluid
serum
zonulin
level),
modulation
microbiota
composition.
Our
findings
reveal
regulatory
roles
L.
mitigating
diabetes-induced
dysfunction
regardless
application
time
(pre-
or
post-treatment),
highlighting
therapeutic
managing
diabetes-related
gastrointestinal
complications.