Potential of Curcumin and Its Analogs in Glioblastoma Therapy
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 351 - 351
Опубликована: Март 18, 2025
Curcumin,
a
polyphenol
found
in
turmeric,
demonstrates
multifaceted
anti-cancer
activity
against
glioblastoma.
Its
therapeutic
potential
stems
from
its
ability
to
modulate
various
molecular
pathways
implicated
glioblastoma
development
and
progression,
enhance
the
effectiveness
of
radiation
therapy,
induce
cancer
cell
death
through
diverse
mechanisms,
including
apoptosis,
autophagy,
cycle
arrest.
These
combined
actions
make
curcumin
promising
candidate
for
treatment,
warranting
further
investigation
into
clinical
application.
In
this
review,
we
summarize
latest
research
on
analogs'
therapy.
Язык: Английский
Advances in liquid biopsy and virtual biopsy for care of patients with glioma: a narrative review
Expert Review of Anticancer Therapy,
Год журнала:
2025,
Номер
unknown, С. 1 - 22
Опубликована: Апрель 5, 2025
The
World
Health
Organization's
2021
classification
of
central
nervous
system
neoplasms
incorporated
molecular
and
genetic
features
for
classifying
gliomas.
Classification
gliomas
located
in
deep-seated
structures
became
a
clinical
conundrum
given
the
absence
crucial
pathological
data.
Advances
noninvasive
imaging
modalities
offered
virtual
biopsy
as
novel
solution
to
this
problem
by
identifying
surrogate
radiomic
signatures.
Liquid
biopsies
blood
or
cerebrospinal
fluid
provided
another
enormous
opportunity
genomic,
metabolomic
proteomic
We
summarize
appraise
current
state
evidence
with
regards
liquid
care
patients
PubMed,
Embase
Google
Scholar
were
searched
on
7/30/2024
relevant
articles
published
after
year
2013
English
language.
A
large
body
preclinical
preliminary
suggests
that
is
possible
combined
use
multiple
conjunction
machine
learning
radiomics.
Likewise,
focused
ultrasound
may
be
valuable
tool
obtain
genomic
data
regarding
glioma
minimally
invasive
manner.
These
will
likely
become
an
integral
part
future.
Язык: Английский
TW-YOLO: An Innovative Blood Cell Detection Model Based on Multi-Scale Feature Fusion
Sensors,
Год журнала:
2024,
Номер
24(19), С. 6168 - 6168
Опубликована: Сен. 24, 2024
As
deep
learning
technology
has
progressed,
automated
medical
image
analysis
is
becoming
ever
more
crucial
in
clinical
diagnosis.
However,
due
to
the
diversity
and
complexity
of
blood
cell
images,
traditional
models
still
exhibit
deficiencies
detection.
To
address
detection,
we
developed
TW-YOLO
approach,
leveraging
multi-scale
feature
fusion
techniques.
Firstly,
CNN
(Convolutional
Neural
Network)
convolution
poor
recognition
capabilities
for
certain
features,
so
RFAConv
(Receptive
Field
Attention
Convolution)
module
was
incorporated
into
backbone
model
enhance
its
capacity
extract
geometric
characteristics
from
cells.
At
same
time,
utilizing
pyramid
architecture
YOLO
(You
Only
Look
Once),
enhanced
features
at
different
scales
by
incorporating
CBAM
Block
Module)
detection
head
EMA
(Efficient
Multi-Scale
Attention)
neck,
thereby
improving
ability
Additionally,
meet
specific
needs
designed
PGI-Ghost
(Programmable
Gradient
Information-Ghost)
strategy
finely
describe
gradient
flow
throughout
process
extracting
further
model’s
effectiveness.
Experiments
on
datasets
such
as
BloodCell-Detection-Dataset
(BCD)
reveal
that
outperforms
other
2%,
demonstrating
excellent
performance
task
In
addition
advancing
research,
this
work
offers
strong
technical
support
future
diagnostics.
Язык: Английский
Understanding the Immune System and Biospecimen-Based Response in Glioblastoma: A Practical Guide to Utilizing Signal Redundancy for Biomarker and Immune Signature Discovery
Current Oncology,
Год журнала:
2024,
Номер
32(1), С. 16 - 16
Опубликована: Дек. 28, 2024
Glioblastoma
(GBM)
is
a
primary
central
nervous
system
malignancy
with
median
survival
of
15–20
months.
The
presence
both
intra-
and
intertumoral
heterogeneity
limits
understanding
biological
mechanisms
leading
to
tumor
resistance,
including
immune
escape.
An
attractive
field
research
examine
treatment
resistance
are
signatures
composed
cluster
differentiation
(CD)
markers
cytokines.
CD
surface
expressed
on
various
cells
throughout
the
body,
often
associated
cells.
Cytokines
effector
molecules
system.
Together,
cytokines
can
serve
as
useful
biomarkers
reflect
status
in
patients
GBM.
However,
there
gaps
intricate
interactions
between
GBM
peripheral
how
these
change
standard
immune-modulating
treatments.
key
true
nature
through
multi-omic
analysis
progression
response.
This
review
aims
identify
potential
non-invasive
blood-based
that
contribute
an
signature
approaches,
better
involvement
Язык: Английский