Vitamin B6, cardiovascular diseases, and diabetes mellitus DOI Creative Commons
A.A. Serhiyenko,

T.T. Dolinay,

Володимир Сегін

и другие.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2025, Номер 21(1), С. 66 - 76

Опубликована: Фев. 23, 2025

Vitamin B6 is a broad term for six water-soluble vitamins that can change forms. These include pyridoxal, pyridoxine, pyridoxamine, and their 5-phosphorylated forms, which are pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate, pyridoxamine 5’-phosphate. PLP the biologically active form of vitamin B6. It works as coenzyme in many enzymatic processes speed up body’s most important metabolic reactions, including synthesis, conversion degradation amines amino acids, supply one-carbon units, transsulfuration, synthesis tetrapyrrole compounds polyamines. also has big impact on metabolism homocysteine biosynthesis different neurotransmitters. inhibits production reactive oxygen species advanced glycation end products, genotoxic linked to aging diabetes mellitus (DM), so it an antioxidant. In addition, functions modulator transcription factors, affects activity number enzymes, bind steroid hormone receptors, playing role membrane transport. Researchers have reported patients with type 2 DM cardiovascular disease (CVD) exhibit lower levels B6, whereas taking supplements lowers risk its vascular complications. We still don’t fully understand mechanisms underlying relationship between DM. Instead, growing body evidence suggests may protect against complications through scavenger species. deficiency been clinically significant diseases, autism, schizophrenia, Alzheimer’s disease, Parkinson’s epilepsy, Down syndrome, DM, cancer, although remain largely unclear. The purpose this review was discuss specifics CVD mellitus, well analyze new trends directions future research. analysis focused biological tryptophan metabolism, correlation CVD, diabetes, DNA damage diabetes. search conducted Scopus, Science Direct (from Elsevier) PubMed, MEDLINE databases. keywords used were “vitamin B6”, “cardiovascular disease”, “diabetes mellitus”. A manual bibliography publications identify study results could not be found during online search.

Язык: Английский

Vitamin B6, cardiovascular diseases, and diabetes mellitus DOI Creative Commons
A.A. Serhiyenko,

T.T. Dolinay,

Володимир Сегін

и другие.

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), Год журнала: 2025, Номер 21(1), С. 66 - 76

Опубликована: Фев. 23, 2025

Vitamin B6 is a broad term for six water-soluble vitamins that can change forms. These include pyridoxal, pyridoxine, pyridoxamine, and their 5-phosphorylated forms, which are pyridoxal 5’-phosphate (PLP), pyridoxine 5’-phosphate, pyridoxamine 5’-phosphate. PLP the biologically active form of vitamin B6. It works as coenzyme in many enzymatic processes speed up body’s most important metabolic reactions, including synthesis, conversion degradation amines amino acids, supply one-carbon units, transsulfuration, synthesis tetrapyrrole compounds polyamines. also has big impact on metabolism homocysteine biosynthesis different neurotransmitters. inhibits production reactive oxygen species advanced glycation end products, genotoxic linked to aging diabetes mellitus (DM), so it an antioxidant. In addition, functions modulator transcription factors, affects activity number enzymes, bind steroid hormone receptors, playing role membrane transport. Researchers have reported patients with type 2 DM cardiovascular disease (CVD) exhibit lower levels B6, whereas taking supplements lowers risk its vascular complications. We still don’t fully understand mechanisms underlying relationship between DM. Instead, growing body evidence suggests may protect against complications through scavenger species. deficiency been clinically significant diseases, autism, schizophrenia, Alzheimer’s disease, Parkinson’s epilepsy, Down syndrome, DM, cancer, although remain largely unclear. The purpose this review was discuss specifics CVD mellitus, well analyze new trends directions future research. analysis focused biological tryptophan metabolism, correlation CVD, diabetes, DNA damage diabetes. search conducted Scopus, Science Direct (from Elsevier) PubMed, MEDLINE databases. keywords used were “vitamin B6”, “cardiovascular disease”, “diabetes mellitus”. A manual bibliography publications identify study results could not be found during online search.

Язык: Английский

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