The systemic inflammation response index as risks factor for all-cause and cardiovascular mortality among individuals with respiratory sarcopenia
BMC Pulmonary Medicine,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 26, 2025
Respiratory
sarcopenia
is
associated
with
poor
outcomes,
yet
effective
biomarkers
for
risk
stratification
remain
limited.
This
study
investigates
the
associations
between
complete
blood
count
(CBC)-derived
inflammatory
biomarkers,
including
neutrophil-to-lymphocyte
ratio
(NLR),
neutrophil-monocyte-to-lymphocyte
(NMLR),
and
systemic
inflammation
response
index
(SIRI)
both
all-cause
cardiovascular
mortality
in
patients
respiratory
sarcopenia.
We
conducted
a
cohort
analysis
of
1,673
adults
possible
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2007
to
2012,
follow-up
through
December
31,
2019.
Possible
was
assessed
via
peak
expiratory
flow
rate
(PEFR).
Multivariable
Cox
regression
models
evaluated
NLR,
NMLR,
SIRI,
adjusted
demographic,
socioeconomic,
health-related
covariates.
Additional
CBC-derived
(PLR,
dNLR,
MLR,
SII)
were
analysed,
mediation
albumin's
role
as
partial
mediator
mortality.
Over
median
116
months,
263
deaths
occurred,
68
causes.
Elevated
SIRI
significantly
increased
risks
emerged
strongest
predictor,
hazard
ratios
(HRs)
1.65
(95%
CI,
1.23–2.22)
3.18
1.83–5.53)
Albumin
partially
mediated
relationship
(12.1%).
are
sarcopenia,
demonstrating
highest
predictive
power.
Integrating
into
clinical
assessments
may
aid
identifying
high-risk
patients,
allowing
targeted
interventions.
Язык: Английский
Proposed Novel Heart Failure Biomarkers and Their Association with Length of Hospital Stay and Mortality: A Retrospective Observational Pilot Study
Diagnostics,
Год журнала:
2025,
Номер
15(5), С. 589 - 589
Опубликована: Фев. 28, 2025
Background/Objectives:
Chronic
heart
failure
(CHF)
remains
a
significant
global
health
burden,
with
high
morbidity,
prolonged
hospitalizations,
and
increased
mortality.
Traditional
biomarkers
such
as
NT-proBNP
provide
prognostic
value;
however,
novel
biomarker
ratios
may
enhance
risk
stratification.
This
study
evaluated
the
predictive
utility
of
NT-proBNP-to-albumin
ratio
(NTAR),
red
cell
distribution
width-to-eGFR
(RGR),
width-to-fibrinogen
(RFR)
for
hospital
length
stay
(LOS),
extended
hospitalization
(ELOS),
in-hospital
mortality,
6-month
all-cause
Methods:
A
retrospective
observational
pilot
was
conducted
on
382
CHF
admissions
(2022-2024)
comprehensive
laboratory
assessment.
Biomarker
performance
assessed
through
uni-
multivariate
logistic
regression,
receiver
operating
characteristic
curve,
Cox
proportional
hazards
stepwise
methods
analyses
refining
models.
Results:
NTAR
RGR
emerged
predictors
outcomes.
demonstrated
moderate
correlation
LOS
(r
=
0.45,
p
<
0.001)
an
independent
predictor
ELOS
(AUC
0.697,
OR
2.438,
0.001),
outperforming
NT-proBNP.
Additionally,
significantly
predicted
mortality
0.768,
4.461,
0.766,
4.185,
0.001).
strongest
0.785,
HR
2.18,
0.005),
highlighting
its
role
in
renal
dysfunction
erythropoietic
alterations
CHF.
The
RFR
observed
value
minimal.
Conclusions:
In
our
study,
offered
valuable
underscoring
interplay
cardiac
stress,
nutritional
status,
function
prognosis.
Further
multicenter
validation
is
warranted
these
biomarkers.
Язык: Английский
The value of neutrophil-to-lymphocyte ratio predicting cardiovascular outcomes for patients with diabetes: A meta-analysis
Jiazhu Zhang,
Qi Bao,
Yingli Mao
и другие.
Asian Journal of Surgery,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
The Effects of Beta-Blockers on Leukocytes and the Leukocyte Subpopulation in Heart Failure Patients
Biomedicines,
Год журнала:
2024,
Номер
12(12), С. 2907 - 2907
Опубликована: Дек. 20, 2024
Background/Objectives:
Some
specific
types
of
white
blood
cells
(WBCs)
and
the
neutrophil/lymphocyte
ratio
(NLR)
are
independent
predictors
outcome
for
heart
failure
(HF)
patients.
WBC
redistribution
is
induced
by
catecholamines,
therefore
we
evaluate
how
different
beta-blockers
(BBs)
influence
it.
Methods:
The
HF
patients
were
clinically
evaluated,
was
drawn
to
measure
N-Terminal
pro–B-type
natriuretic
peptide
(NT-proBNP),
WBC-differential
formula,
etc.
Results:
On
admission,
61.16%
who
used
a
BB
had
no
significant
difference
in
number
lymphocytes
(Lym)
neutrophils
(Neu),
but
NLR
NT-
proBNP
significantly
lower
compared
with
those
without
BB.
NT-proBNP
correlated
dose
on
admission
treated
Metoprolol
(Met)
as
Carvedilol
(Car).
type
responsible
6.1%
5.9%
variability
Lym
Neu,
respectively.
Patients
≥100
mg
Met/day
higher
number,
not
reduced
NLR,
doses.
≥25
Car/day
greater
Neu
doses,
increased
NLR.
Conclusions:
However,
both
BBs
same
rehospitalization
rate
during
12
month
follow-up
an
improved
outcome.
Язык: Английский